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Protein Engineering Potential Inhibitor Of Detrimental Immune Responses, Nathaniel L. Blalock, Eric T. Boder, Liang Fang
Protein Engineering Potential Inhibitor Of Detrimental Immune Responses, Nathaniel L. Blalock, Eric T. Boder, Liang Fang
EURēCA: Exhibition of Undergraduate Research and Creative Achievement
On the surface of immune cells, class II major histocompatibility complex proteins (MHCII) present antigenic peptides for CD4+ T cell recognition, which initiate a variety of antigen-specific immune responses such as antibody response or cytotoxic T cell activation. In people with with auto-immune diseases including but not limited to type 1 diabetes, multiple sclerosis, and rheumatoid arthritis, detrimental immune responses occur after the presentation of antigenic peptides. A single-chain, minimal MHCII (scm-MHCII) has been designed to retain its function as an antigen-presenting protein with a simplified structure that can be easily produced and manipulated in a laboratory by recombinant microbial …