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Identification Of Synthetic Host Defense Peptide Mimics That Exert Dual Antimicrobial And Anti-Inflammatory Activities, Nicolás Navasa, Abhigyan Som, Avital Percher, Richard W. Scott, Gregory N. Tew, Juan Anguita
Identification Of Synthetic Host Defense Peptide Mimics That Exert Dual Antimicrobial And Anti-Inflammatory Activities, Nicolás Navasa, Abhigyan Som, Avital Percher, Richard W. Scott, Gregory N. Tew, Juan Anguita
Gregory N. Tew
A group of synthetic antimicrobial oligomers, inspired by naturally occurring antimicrobial peptides, were analyzed for the ability to modulate innate immune responses to Toll-like receptor (TLR) ligands. These synthetic mimics of antimicrobial peptides (SMAMPs) specifically reduced cytokine production in response to Staphylococcus aureus and the S. aureus component lipoteichoic acid (LTA), a TLR2 agonist. Anti-inflammatory SMAMPs prevented the induction of tumor necrosis factor (TNF), interleukin 6 (IL-6), and IL-10 in response to S. aureus or LTA, but no other TLR2 ligands. We show that these SMAMPs bind specifically to LTA in vitro and prevent its interaction with TLR2. Importantly, the …
Anion Mediated Activation Of Guanidine Rich Small Molecules, Abhigyan Som, Yongjiang Xu, Richard W. Scott, Gregory N. Tew
Anion Mediated Activation Of Guanidine Rich Small Molecules, Abhigyan Som, Yongjiang Xu, Richard W. Scott, Gregory N. Tew
Gregory N. Tew
No abstract provided.