Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Entire DC Network
Examining The Effects Of Synthetic Dye Yellow No. 5 (Tartrazine) Exposure On Mouse Neuro2a Neurons In Vitro, Jenna L. Farnum
Examining The Effects Of Synthetic Dye Yellow No. 5 (Tartrazine) Exposure On Mouse Neuro2a Neurons In Vitro, Jenna L. Farnum
Honors Undergraduate Theses
Yellow Dye No. 5, also known as tartrazine (TRZ), is widely used[1] and has an accepted daily intake (ADI) of 0-7.5 mg/kg of body weight per day[2]. Consuming TRZ dosages greater than the ADI can lead to reduced levels of antioxidant enzymes in the brain, chromosomal alterations, or neuronal dendritic changes, [3, 4] which can result in oxidative stress, impaired neuronal functioning and potential mutagenic effects. Within the ADI, there have been observed reductions of the copper zinc superoxide dismutase-1 (SOD1) enzyme levels.[5]We hypothesize that TRZ interacts pre-translationally inside the cell, resulting in the reduction of SOD1 mRNA. …