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Design Of A Physical Windkessel Model For Use In Lvad In-Vitro Benchtop Modeling, Kyle W. Beggs
Design Of A Physical Windkessel Model For Use In Lvad In-Vitro Benchtop Modeling, Kyle W. Beggs
HIM 1990-2015
Despite improved life expectancy compared to medical management alone, Ventricular Assist Device (VAD) recipients show survival rates of 80% at 12 months and 70% at 24 months. A large portion of VAD-associated mortality results from increased risk of stroke with an event frequency reported between 14-47%. Recent concerns have been raised about unprecedented increases of thrombus formation in VAD recipients with subsequent reports pointing towards implantation techniques as a critical contributor to these events. Thus, the overall prognosis with mechanical support can improve by advancing the surgeon’s approach to VAD implantation. Previous studies using Computational Fluid Dynamics (CFD) were aimed …
Effects Of Binary Solvent System On Morphology Of Particles, Patrick Besana
Effects Of Binary Solvent System On Morphology Of Particles, Patrick Besana
HIM 1990-2015
Recent advancements in cancer research has led to the synthesis of a new drug known as docetaxel. Meant to replace paclitaxel, its more natural counterpart whose ingredients are difficult to obtain, the drug is known to effectively treat a wide array of cancers, including breast cancer, ovarian cancer, and prostate cancer. The establishment of a synthetic alternative to paclitaxel has increased its bioavailability, thereby lowering the cost needed to utilize the drug. Still, the limiting factor in minimizing costs is the method in which the drug is processed. Current methods in drug processing have their limitations, which include the introduction …
Development Of A Set Of Force Response Equations To Represent The Musculature In Infants To Study Development Dysplasia Of The Hip, Brendan Jones
Development Of A Set Of Force Response Equations To Represent The Musculature In Infants To Study Development Dysplasia Of The Hip, Brendan Jones
HIM 1990-2015
This paper describes how a force response equation was created to model muscles, tendons, and ligaments of the hip joint to improve a biomechanical model of an infant hip to study Developmental Dysplasia of the Hip (DDH). DDH is the most common abnormality in newborn infants and is defined as any amount of instability in the hip including complete dislocation. Researchers at our institution are attempting to increase the success rate of treatment methods by creating computer models of the biomechanics of infant hip instability and dislocation. The computer model used a scaled adult pelvis, femur, tibia, fibula and foot …
Dynamic Response Of A Multi-Span Curved Beam From Moving Transverse Point Loads, Amanda Alexander
Dynamic Response Of A Multi-Span Curved Beam From Moving Transverse Point Loads, Amanda Alexander
HIM 1990-2015
This thesis describes how to evaluate a first-order approximation of the vibration induced on a beam that is vertically curved and experiences a moving load of non-constant velocity. The curved beam is applicable in the example of a roller coaster. The present research in the field does not consider a curved beam nor can similar research be applied to such a beam. The complexity of the vibration of a curved beam lies primarily in the description of the variable magnitude of the moving load applied. Furthermore, this motion is also variable. This thesis will present how this beam will displace …
Hybrid Carbon Fiber Alumina Nanocomposite For Non-Contact Stress Sensing Via Piezospectroscopy, Imad Hanhan
Hybrid Carbon Fiber Alumina Nanocomposite For Non-Contact Stress Sensing Via Piezospectroscopy, Imad Hanhan
HIM 1990-2015
Carbon ber composites have become popular in aerospace structures and applications due to their light weight, high strength, and high performance. Recently, scientists have begun investigating hybrid composites that include fibers and particulate fillers, since they allow for advanced tailoring of mechanical properties, such as improved fatigue life. This project investigated a hybrid carbon ber reinforced polymer (HCFRP) that includes carbon fiber and additional alumina nanoparticle fillers, which act as embedded nano stress-sensors. Utilizing the piezospectroscopic e ect, the photo-luminescent spectral signal of the embedded nanoparticles has been monitored as it changes with stress, enabling non-contact stress detection of the …
Design And Evaluation Of A Test Platform For Thermal Mechanical And Acoustical Loading, Abdi Jasmin
Design And Evaluation Of A Test Platform For Thermal Mechanical And Acoustical Loading, Abdi Jasmin
HIM 1990-2015
Next generation hypersonic cruise vehicle components will be subjected to a collection of loads not achievable in contemporary mechanical test platform. The purpose of this thesis is to demonstrate the design of a unique test platform for combined extreme environment (P-CEEn) needed to replicate thermal, acoustic and mechanical loading to be imparted on hypersonic fuselage panels. The panels are typically subjected to super-imposed cycling from hypersonic shock/impingement and aerodynamic pressure from the usual ascent-cruise-decent motion of the aircrafts combined with mechanical vibration at acoustic frequencies; moreover, these slender components will undergo conventional mechanical fatigue with compressive mean stress due to …
Frequency-Domain Faraday Rotation Spectroscopy (Fd-Frs) For Functionalized Particle And Biomolecule Characterization, Richard Murdock
Frequency-Domain Faraday Rotation Spectroscopy (Fd-Frs) For Functionalized Particle And Biomolecule Characterization, Richard Murdock
HIM 1990-2015
In this study, the magnetically-induced vibrations of functionalized magnetic particle suspensions were probed for the development of a novel optical spectroscopy technique. Through this work (1) the frequency-dependence of the faraday rotation in ferrofluids and (2) the extension of this system to elucidating particle size and conformation as an alternative immunossay to costly and labor/time intensive Western Blotting and ELISA has been shown. With its sensitivity and specificity, this method has proven to be a promising multi-functional tool in biosensing, diagnostic, and therapeutic nanomedicine efforts. Due to its ubiquitous nature in all optically-transparent materials, the farady rotation, or circular birefringence, …
Nanocluster Thin-Films For Sensor Applications, Joseph Serritella
Nanocluster Thin-Films For Sensor Applications, Joseph Serritella
HIM 1990-2015
The ability to sense gas such as methane can provide an early warning system to protect human lives. High demand for the ability to sense the world around us has provided an extensive area of research for sensor technology. In particular, current sensor technology, specifically for methane, has provided sensors that require a heated environment to function. The majority of current methane sensors function at temperatures between 150°C and 450°C [1-3]. This thesis will explore an approach to produce a room temperature methane sensor.
A Laboratory Scale Assessment Of The Effect Of Chlorine Dioxide Pre-Oxidation On Disinfection By-Product Formation For Two Surface Water Supplies, Angela Rodriguez
A Laboratory Scale Assessment Of The Effect Of Chlorine Dioxide Pre-Oxidation On Disinfection By-Product Formation For Two Surface Water Supplies, Angela Rodriguez
HIM 1990-2015
Chemical disinfection is the cornerstone of safe drinking water. However, the use of chemical disinfection results in the unintentional formation of disinfection by-products (DBPs), an outcome of reactions between the disinfectant and natural organic matter (NOM) present in the native (raw) water. DBPs are suspected carcinogens, and as such, have been regulated by the U.S. Environmental Protection Agency (USEPA) under the Safe Drinking Water Act (SDWA). This document reports the results of a study that investigated the use of chlorine dioxide pre-oxidation for the reduction of DBP precursors, and subsequently, DBP formation potential (FP). To determine the effectiveness of the …
A Mechanics-Based Approach For Putt Distance Optimization, Pascual Santiago-Martinez
A Mechanics-Based Approach For Putt Distance Optimization, Pascual Santiago-Martinez
HIM 1990-2015
Quantifying the core mechanics of putting is imperative to developing a reliable model that predicts post-collision ball behavior. A preliminary model for the stroking motion of putting and putter-ball collision is developed alongside experiments, establishing an empirical model that supports the theory. The goal of the present study is to develop a correlation between the backstroke of a putt, or the pre-impact translation of the putter, and the post-impact displacement of the golf ball. This correlation is subsequently utilized to generate an algorithm that predicts the two-dimensional ball trajectory based on putt displacement and putting surface texture by means of …
Understanding And Modeling Pathways To Thrombosis, John Seligson
Understanding And Modeling Pathways To Thrombosis, John Seligson
HIM 1990-2015
This research will investigate techniques to create a sensor that is responsive to methane at 23°C. The approach will use the integration of a very thin film, which changes its resistive properties when methane gas is applied, deposited atop the surface of a piezoelectric substrate. An aluminum thin film interdigital transducer will launch a surface acoustic wave (SAW) that travels under the sensor’s gas-sensitive resistive thin film. The SAW/resistive film interaction changes the SAW amplitude, phase and delay. For this work, three films, tin dioxide (SnO2), zinc oxide (ZnO) and palladium (Pd) [1, 2] will be studied. Gas detection will …
Compendium Of Thermoviscoplasticity Modeling Parameters For Materials Under Non-Isothermal Fatigue, Nathan O'Nora
Compendium Of Thermoviscoplasticity Modeling Parameters For Materials Under Non-Isothermal Fatigue, Nathan O'Nora
HIM 1990-2015
Viscoplasticity models allow for the prediction of the inelastic behavior of materials, taking into account the rate-dependence. In order to model the response under non-isothermal conditions experienced by many components, such as those in turbomachinery, however, it is necessary to incorporate temperature-dependence. Additionally, for materials subjected to thermal shock, temperature rate-dependence is also important. The purpose of this research is to develop a method of determining Chaboche viscoplasticity parameters that allows for consistent behavior with changing temperature. A quartet of candidate materials, 304 stainless steel, IN617, DS GTD-111, and Ti6242S, were chosen for their applications in turbomachinery, such as gas …
Modeling Financial Markets Using Concepts From Mechanical Vibrations And Mass-Spring Systems, Michael Gandia
Modeling Financial Markets Using Concepts From Mechanical Vibrations And Mass-Spring Systems, Michael Gandia
HIM 1990-2015
This thesis describes a method of modeling financial markets by utilizing concepts from mechanical vibration. The models developed represent multi-degree of freedom, mass-spring systems. The economic principles that drive the design are supply and demand, which act as springs, and shareholders, which act as masses. The primary assumption of this research is that events cannot be predicted but the responses to those events can be. In other words, economic stimuli create responses to a stock’s price that is predictable, repeatable and scientific. The approach to determining the behavior of various financial markets encompassed techniques such as Fast Fourier Transform and …
Effects Of Relaxed Assumptions On The State Switching Technique, Stephen Ilardi
Effects Of Relaxed Assumptions On The State Switching Technique, Stephen Ilardi
HIM 1990-2015
This thesis explores the effects of two assumptions commonly used in mathematical models related to a piezoelectric damping method known as State Switching. The technique relies on changing the stiffness state of a piezoelectric patch through control of the electrical boundary conditions. The transition between stiffness states is assumed to occur instantaneously and in concurrence with the switch event. In actuality, the transition will occur over a finite time and will trail behind the switch event by a finite time. For these assumptions to be valid, the effects of switch duration and delay on the performance of the State Switching …
Organizational Accountability In The W.A.S.H. Sector: Integrating Sustainability Factors Into The Definition Of Success, Kaitlyn Jeanis
Organizational Accountability In The W.A.S.H. Sector: Integrating Sustainability Factors Into The Definition Of Success, Kaitlyn Jeanis
HIM 1990-2015
The world's poorest people, most of whom reside in under-developed nations, lack access to clean water and sanitation facilities, nutritious food, and education (UMP, 2005). These conditions are linked to malnutrition, disease, and low life expectancies (WHO). In an effort to reduce global poverty, the United Nations (UN) adopted the Millennium Development Goals (MDGs). Under Goal 7c the UN denotes that by 2015 the population without sustainable access to safe drinking water and basic sanitation as compared to the proportion who do should be halved. As a response to this objective the international development (ID) sector has implemented projects aimed …
The Tlc Method For Modeling Creep Deformation And Rupture, David May
The Tlc Method For Modeling Creep Deformation And Rupture, David May
HIM 1990-2015
This thesis describes a novel new method, termed the Tangent-Line-Chord (TLC) method, that can be used to more efficiently model creep deformation dominated by the tertiary regime. Creep deformation is a widespread mechanical mode of failure found in high-stress and temperature mechanical systems. To accurately simulate creep and its effect on structures, researchers utilize finite element analysis (FEA). General purpose FEA packages require extensive amounts of time and computer resources to simulate creep softening in components because of the large deformation rates that continuously evolve. The goal of this research is to employ multi-regime creep models, such as the Kachanov-Rabotnov …
Scalable Nano Particle Production Of Low Bioavailability Pharmaceuticals For Augmented Aqueous Solubility, Aaron Madden
Scalable Nano Particle Production Of Low Bioavailability Pharmaceuticals For Augmented Aqueous Solubility, Aaron Madden
HIM 1990-2015
The billion dollar pharmaceutical research and development pipeline suffers greatly from high attrition rates of novel therapeutic compounds within pre-clinical and clinical trials. Poor bioavailability in many new drugs, originating in the various methodologies of high throughput screening, may explain part of these growing failure rates. One interpretation of this phenomenon relies on bioavailability's correlation with aqueous solubility; much modern processing allows chemicals to fully develop without touching water, yielding upwards of 90% of new chemical entities practically insoluble in aqueous media. Thus, one approach to alleviating bioavailability and potentially clinical attrition rates necessitates augmented aqueous solubility. The amorphous nanoparticle …
The Thermodynamics Of Planetary Engineering On The Planet Mars, Christopher Barsoum
The Thermodynamics Of Planetary Engineering On The Planet Mars, Christopher Barsoum
HIM 1990-2015
Mars is a potentially habitable planet given the appropriate planetary engineering efforts. In order to create a habitable environment, the planet must be terraformed, creating quasi-Earth conditions. Benchmarks for minimum acceptable survivable human conditions were set by observing atmospheric pressures and temperatures here on Earth that humans are known to exist in. By observing a positive feedback reaction, it is shown how the sublimation of the volatile southern polar ice cap on Mars can increase global temperatures and pressures to the benchmarks set for minimum acceptable survivable human conditions. Given the degree of uncertainty, utilization of pressure scale heights and …
Experimental And Numerical Investigations Of Microdroplet Evaporation With A Forced Pinned Contact Line, Kevin Gleason
Experimental And Numerical Investigations Of Microdroplet Evaporation With A Forced Pinned Contact Line, Kevin Gleason
HIM 1990-2015
Experimental and numerical investigations of water microdroplet evaporation on heated, laser patterned polymer substrates are reported. The study is focused on both (1) validating numerical models with experimental data, (2) identifying how changes in the contact line infuences evaporative heat transfer and (3) determining methods of controlling contact line dynamics during evaporation. Droplets are formed using a bottom-up methodology, where a computer-controlled syringe pump supplies water to a ~200[micro]m in diameter fluid channel within the heated substrate. This methodology facilitates precise control of the droplets growth rate, size, and inlet temperature. In addition to this microchannel supply line, the substrate …
Ignition Studies Of Diisopropyl Ketone, A Second-Generation Biofuel, Owen Pryor
Ignition Studies Of Diisopropyl Ketone, A Second-Generation Biofuel, Owen Pryor
HIM 1990-2015
This thesis focuses on ignition of diisopropyl ketone (DIPK), a new biofuel candidate that is produced by endophytic conversion. The ignition delay times behind reflected shockwaves were modeled in a high-pressure shock tube. The ignition delay times were compared to other biofuels and gasoline surrogates. Parametric studies of the ignition delay experiments were performed between 1-10 atm and 900 -1200K. An OH optical sensor was developed in conjunction for the ignition delay experiments. The OH optical sensor uses a microwave discharge lamp to generate light at 308 nm that will then be shined through the combustion reaction. Using Beer-Lambert law …
Development And Validation Of An Absorption Sensor For Time-Resolved Measurements Of Co And Co2, Kyle Thurmond
Development And Validation Of An Absorption Sensor For Time-Resolved Measurements Of Co And Co2, Kyle Thurmond
HIM 1990-2015
A sensor was developed for simultaneous measurements of carbon monoxide and carbon dioxide fluctuations in internal combustion engine exhaust gases. This sensor utilizes low-cost and compact LEDs that emit in the 3-5[micro]m wavelength range which are more appropriate for practical applications than the more traditionally used lasers. An affordable, fast response sensor that can measure these gases has broad application that can lead to more efficient, fuel flexible engines and regulations of harmful emissions. LEDs have a more spectrally broad and diverging emission than lasers which presented many design challenges. The optical design software ZEMAX was utilized to overcome these …
Fracture Toughness Of A Hyperelastic Material During Surgical Cutting, Kevin Smith
Fracture Toughness Of A Hyperelastic Material During Surgical Cutting, Kevin Smith
HIM 1990-2015
Despite being one of the most important organs of vertebrates, the material properties of skin are also one of the most poorly understood. In the field of designing medical devices and surgical tools there are significant advantages to having a model that describes the interaction of forces between a blade tip and skin during surgical cutting. In general, skin can best be described as a composite layer consisting of a viscoelastic dermis with interwoven collagen and elastin fibers beneath a superficial epidermis. The purpose of this research is to study the fracture toughness of porcine skin during practical cutting applications, …
Characterization Of Polyetherimide Under Static, Dynamic, And Multiple Impact Conditions, Bryan Zuanetti
Characterization Of Polyetherimide Under Static, Dynamic, And Multiple Impact Conditions, Bryan Zuanetti
HIM 1990-2015
The application of polymers in robust engineering designs is on the rise due to their excellent mechanical properties such as high fracture toughness, specific strength, durability, as well as, thermal and chemical resistances. Implementation of some advanced polymeric solids is limited due to the lack of available mechanical properties. In order for these materials to endure strenuous engineering designs it is vital to investigate their response in multiple loading rates and conditions. In this thesis, the mechanical response of polyethermide (PEI) is characterized under quasi-static, high strain rate, and multiple impact conditions. Standard tension, torsion, and compression experiments are performed …
A Simplified Approach To Thermomechanical Fatigue And Application To V-Shaped Notches, Thomas Bouchenot
A Simplified Approach To Thermomechanical Fatigue And Application To V-Shaped Notches, Thomas Bouchenot
HIM 1990-2015
A vast array of high value parts in land- and air-based turbomachinery are subjected to non-isothermal cycling in the presence of mechanical loading. Crack initiation, growth and eventual failure more significantly reduce life in these components compared to isothermal conditions. More accurate simulation of the stress and strain evolution at critical locations of components, as well as test specimens, can lead to a more accurate prediction of remaining life to a structural integrity specialists. The focus of this thesis is to characterize the effects of thermomechanical fatigue (TMF) on generic turbomachinery alloy. An expression that can be used to estimate …
Microscopic Surface Textures Created By Interfacial Flow Instabilities, Jing Gu
Microscopic Surface Textures Created By Interfacial Flow Instabilities, Jing Gu
HIM 1990-2015
In nature, microscopic surface textures impact useful function, such as the drag reduction of shark skin (Dean & Bhushan, 2010) and superhydrophobicity of the lotus leaf(Pan, Kota, Mabry, & Tuteja, 2013). In this study, we explore these phenomena by re-creating microscopic surface textures via the method of interfacial flow instability in drying polyvinylidene fluoride (PVDF) acetone solutions. In general, PVDF films can be made using either spin coating or electrospray deposition with various weight concentrations in acetone. In order to study the morphology of the porous structure of PVDF films, wet deposition samples were fabricated by spin coating or near-field …
A Computed Tomography-Based Model Of The Infant Hip Anatomy For Dynamic Finite Element Analysis Of Hip Dysplasia Biomechanics, Kyle Snethen
A Computed Tomography-Based Model Of The Infant Hip Anatomy For Dynamic Finite Element Analysis Of Hip Dysplasia Biomechanics, Kyle Snethen
HIM 1990-2015
Newborns diagnosed with hip dysplasia face severe consequences when treatments fail. The Pavlik harness presents the most common worldwide treatment for correcting this medical hip abnormality in newborns, but becomes increasingly ineffective as subluxation increases. A dynamic finite element analysis on the hip joint would yield results that could provide insight to physicians as to how the Pavlik harness could be optimized to increase its success rate and develop patient-specific treatment plans. The study completes the first step in such an analysis by generating a three-dimensional model of an infant hip joint directly derived from computed tomography imaging in order …
Implementation And Testing Of A Blackbox And A Whitebox Fuzzer For File Compression Routines, Toby Tobkin
Implementation And Testing Of A Blackbox And A Whitebox Fuzzer For File Compression Routines, Toby Tobkin
HIM 1990-2015
Fuzz testing is a software testing technique that has risen to prominence over the past two decades. The unifying feature of all fuzz testers (fuzzers) is their ability to somehow automatically produce random test cases for software. Fuzzers can generally be placed in one of two classes: black-box or white-box. Blackbox fuzzers do not derive information from a program's source or binary in order to restrict the domain of their generated input while white-box fuzzers do. A tradeoff involved in the choice between blackbox and whitebox fuzzing is the rate at which inputs can be produced; since blackbox fuzzers need …
Production, Control And Actuation Of Micron-Sized Particles In A Microfluidic T-Junction, James Wilson
Production, Control And Actuation Of Micron-Sized Particles In A Microfluidic T-Junction, James Wilson
HIM 1990-2015
This research is directed towards understanding the mechanisms associated with the manufacture of solid microspheres less than 100 [micrometers], from liquid droplets with nanosuspensions in a microfluidic T-junction, which are heated downstream of the channel. Preliminary material characterization tests on colloidal suspensions of alumina and copper oxide demonstrate promising temperature dependent viscosity results indicating solidification in the temperature range of 40°C-50°C. The solidification mechanism is referred to as Temperature Induced Forming and is described by polymeric bridges formed between nanoparticles in suspension at elevated temperatures, resulting in a solid structure. The polymer network results from the ionization of alumina at …
Numerical Simulation Of Fracture Of A Nano-Paper Coated E-Glass/Polyester Composite With Thermal Damage, Zachary Graham
Numerical Simulation Of Fracture Of A Nano-Paper Coated E-Glass/Polyester Composite With Thermal Damage, Zachary Graham
HIM 1990-2015
Aerospace research for next-generation travel increasingly focuses on the use of advanced composites to reduce weight and cost while retaining strength. One subset of materials with great potential is based on the combination of resin matrix and glass-fiber reinforcement. This research explores the application of a candidate nanopaper coating with a given composite. Prior research applied a set of given heat fluxes to the top surface of the composite for a set of given periods of time, and subsequently performed a 3-point flexural test to determine the elastic modulus for both the coated and uncoated composite for all of the …
Strategically Minded Dynamic Analysis Of Strategic Flight Bat Maneuvers, Marie Kaspryzk
Strategically Minded Dynamic Analysis Of Strategic Flight Bat Maneuvers, Marie Kaspryzk
HIM 1990-2015
CATD was not only adequate for analyzing the pursuit of erratically moving prey but also worked well when analyzing the pursuit of prey that remained stationary. It cannot be fully concluded that bats utilize the CATD strategy to successfully capture erratically flying prey. The angle remains relatively constant but does not exhibit a zero change in angle as by definition. The large forces experienced by the bat were seen when the bat began to rotate its body about its pitch axis or when the bat made a large turn. Moments were seen specifically when the bat began to bank into …