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Structure And Morphology Of Photoreactive Monomer–Nanoparticle Mixtures Under Patterned Irradiation, Shreyas Pathreeker
Structure And Morphology Of Photoreactive Monomer–Nanoparticle Mixtures Under Patterned Irradiation, Shreyas Pathreeker
Dissertations - ALL
Establishing processing–structure relationships is central to materials science. In this work, we seek answers to whether morphology can be controlled during Light–Induced Self–Writing (LISW) in polymer composite materials, and if yes, how? LISW is based on the ability of light to undergo divergence–free propagation in photoreactive media due to photopolymerization–induced rise in refractive index of the medium. Notably, LISW in polymeric materials has found use predominantly for the fabrication of optical waveguides but has not been explored in polymer–inorganic mixtures. Using through–mask projection which creates a spatially periodic array of optical beams, this work extends LISW to nanoparticle–monomer mixtures to …
Raman Spectroscopic Investigation Of Chondroitinase Abc Treatment After Spinal Cord Injury In An Organotypic Model, Shane Ruberto
Raman Spectroscopic Investigation Of Chondroitinase Abc Treatment After Spinal Cord Injury In An Organotypic Model, Shane Ruberto
Theses - ALL
This study investigated (1) the ability of an organotypic model of spinal cord injury (SCI) to recapitulate significant pathobiological events of in vivo SCI from a Raman spectroscopic perspective, and (2) the Raman spectroscopic effects of chondroitinase ABC (cABC) treatment on said model of SCI. Tissue from mouse spinal cords was excised, sectioned, and placed into culture, before being systematically injured to induce trauma. Cultures with and without cABC treatment were assessed using Raman spectroscopy at varying times post-injury. We demonstrate that Raman spectral phenomena characteristic of SCI can be observed using an organotypic model. By comparing these phenomena with …