Digital Commons Network^™

Experimental Investigation Of The 100 Kev X-Ray Dose Response Of The High-Temperature Thermoluminescence In Lif: Mg, Ti (Tld-100): Theoretical Interpretation Using The Unified Interaction Model, Jayde Livingstone, Y Horowitz, L Oster, H Datz, Michael Lerch, Anatoly Rosenfeld, A Horowitz

Michael L.F. Lerch

The dose response of LiF:Mg,Ti (TLD-100) chips was measured from 1 to 50 000 Gy using 100 keV X rays at the European Synchroton Radiation Facility. Glow curves were deconvoluted into component glow peaks using a computerised glow curve deconvolution (CGCD) code based on first-order kinetics. The normalised dose response, f(D), of glow peaks 4 and 5 and 5b (the major components of composite peak 5), as well as peaks 7 and 8 (two of the major components of the high-temperature thermoluminescence (HTTL) at high levels of dose) was separately determined and theoretically interpreted using the unified interaction model (UNIM). …

A Silicon Strip Detector Dose Magnifying Glass For Imrt Dosimetry, J.H.D Wong, Martin Carolan, Michael Lerch, Marco Petasecca, Sutinder Khanna, V Perevertaylo, Peter Metcalfe, Anatoly Rosenfeld

Michael L.F. Lerch

Purpose: Intensity modulated radiation therapy (IMRT) allows the delivery of escalated radiation dose to tumor while sparing adjacent critical organs. In doing so, IMRT plans tend to incorporate steep dose gradients at interfaces between the target and the organs at risk. Current quality assurance (QA) verification tools such as 2D diode arrays, are limited by their spatial resolution and conventional films are nonreal time. In this article, the authors describe a novel silicon strip detector (CMRP DMG) of high spatial resolution (200 μm) suitable for measuring the high dose gradients in an IMRT delivery. Methods: A full characterization of the …

Comparison Of The New Moskin Detector And Fiber Optic Dosimetry System For Radiotherapy, Ian Kwan, Bong Soo Lee, Wook Jae Yoo, Donghyun Cho, Kyoungwon Jang, Sanghun Shin, Martin Carolan, Michael Lerch, V Perevertaylo, Anatoly Rosenfeld

Michael L.F. Lerch

In radiotherapy, interest in real-time dosimetry stems from the desire to monitor the dose delivered to the target volume and the surrounding normal tissue to enable clinicians to track the progress of the treatment, and prevent surrounding tissue from receiving too much radiation dose. In this study, the dosimetric performance of the new MOSkin dosimeter and a Bicron BCF-20 scintillating fiber was compared to depth dose measurements taken with a Farmer-type ionization chamber. The performance of the MOSkin and BCF-20 detectors in the build-up region of the depth dose curve, where the dose gradient is steep, is also compared to …

Evaluation Of A Thin Microstrip Detector For High Spatial Resolution Dosimetry, J Kalliopuska, Ashley Cullen, Michael Lerch, Marco Petasecca, M Santala, Anatoly Rosenfeld

Michael L.F. Lerch

VTT and Aalto University have supplied thin microstrip detector prototypes to CMRP for evaluation for the high spatial resolution dosimetry. The evaluation for dosimetry in microbeam radiation therapy (MRT) was done in a synchrotron microbeam at ESRF, France. Measurements studied a response of a single strip on the synchrotron microbeam in face-on and edge-on modes using CMRP designed and developed readout electronics for a parallel readout of single strips. Measurements were done in a passive mode without bias voltage and the detector was scanned through an array of intensive planar microbeams with the nominal width of 50 μm. The face-on …

From Hep To Medical Radiation Dosimetry - The Silicon Strip Detector Dose Magnifying Glass, J.H.D Wong, Dean Cutajar, Michael Lerch, Marco Petasecca, T Knittel, Martin Carolan, V Perevertaylo, Peter Metcalfe, Anatoly Rosenfeld

Michael L.F. Lerch

High energy physics (HEP) experiments and research gave rise to the development of high spatial resolution tracking vertex detectors and the accompanying data acquisition systems (DAQ) capable of high temporal resolution measurements. The technology translation from HEP to the day to day medical radiation dosimetry is gradual but certain. This paper discusses the design and development of a high spatial resolution (0.2 mm pitch) silicon strip detector referred to as the Dose Magnifying Glass designed and prototyped by the Centre for Medical Radiation Physics (CMRP), University of Wollongong. The DMG has 128 phosphor implanted n+ strips on a p-type silicon …

Characterisation Of Delta E-E Particle Telescope Using The Ansto Heavy Ion Microprobe, Andrew Wroe, Dale Prokopovich, Michael Lerch, Anatoly Rosenfeld, David Cohen, Mihail Ionescu, Iwan Cornelius, Rainer Siegele, A Fazzi, S Agosteo, A Pola, Mark Reinhard

Michael L.F. Lerch

No abstract provided.

Urethral Spectroscopic Alarm (Usa) Probe For Prostate Implants, Anatoly Rosenfeld, Dean Cutajar, Michael Lerch, George Takacs, J Bucci, L Duggan, M Zaider, M Zelefsky, Gil'ad Cohen

Michael L.F. Lerch

Urethral Spectroscopic Alarm (USA) Probe for Prostate Implants 1A.B. Rosenfeld, 1D.L. Cutajar, 1M.L.F. Lerch, 1G.J. Takacs, 2J.A. Bucci, 2L.J. Duggan, 3M. Zaider, 4M. Zelefsky and 3G.N. Cohen 1Centre for Medical Radiation Physics, University of Wollongong, Wollongong, Australia, 2Institute for Prostate Cancer, St. George Cancer Care Centre, Kogarah, Australia, 3Department of Medical Physics and 4Department of Radiation Oncology, MSKCC, New York, NY Purpose: Prostate implants are associated with excellent biochemical outcome; however, their benefit in terms of overall survival remains unknown. For many patients with early, localized prostate cancer the decision to undergo a treatment of questionable benefit yet because of …

Real-Time In Vivo Dosimetry With Mosfet Detectors In Serial Tomotherapy For Head And Neck Cancer Patients, Zhen-Yu Qi, Xiao-Wu Deng, Shao-Min Huang, Almon Shiu, Michael Lerch, Peter Metcalfe, Anatoly Rosenfeld, Tomas Kron

Michael L.F. Lerch

Purpose

A real-time dose verification method using a recently designed metal oxide semiconductor field effect transistor (MOSFET) dosimetry system was evaluated for quality assurance (QA) of intensity-modulated radiation therapy (IMRT).

Methods and Materials

Following the investigation of key parameters that might affect the accuracy of MOSFET measurements (i.e., source surface distance [SSD], field size, beam incident angles and radiation energy spectrum), the feasibility of this detector in IMRT dose verification was demonstrated by comparison with ion chamber measurements taken in an IMRT QA phantom. Real-time in vivo measurements were also performed with the MOSFET system during serial tomotherapy …

Modelling The Readout Performance Of A New Silicon Photodetector For Use In Pet, Michael Lerch, Philip Simmonds, Robert Ward, Tony Young, George Takacs, Anatoly Rosenfeld, V L Perevertaylo, Steven Meikle

Michael L.F. Lerch

No abstract provided.

Evaluation Of Pixellated, Back-Sided Planar Photodetectors For High-Resolution Imaging Instrumentation, Mark Safavi-Naeini, Michael Lerch, Marco Petasecca, Giorgio Pignatel, Mark Reinhard, Anatoly Rosenfeld

Michael L.F. Lerch

Future generations of solid-state high-energy gamma imaging cameras require pixellated semiconductor photodetectors with the greatest possible detection efficiency. In this paper, a new type of planar silicon PIN photodiode is presented, in which both p+ and n+ electrodes are located on the same side of the device. The design offers highly efficient optical coupling between the backside and scintillator, providing a fill factor of close to 100%. The performance of this detector is modelled using the ISE-TCAD simulator and its electrical and spectroscopic characteristics are experimentally investigated for the case of direct interaction of ionising radiation and also with an …

Mosfet Dosimetry With High Spatial Resolution In Intense Synchrotron-Generated X-Ray Microbeams, Erik Siegbahn, E. Brauer-Krisch, Alberto Bravin, Heidi Nettelbeck, Michael Lerch, Anatoly Rosenfeld

Michael L.F. Lerch

Various dosimeters have been tested for assessing absorbed doses with microscopic spatial resolution in targets irradiated by high-flux, synchrotron-generated, low-energy (∼30–300 keV) x-ray microbeams. A MOSFET detector has been used for this study since its radio sensitive element, which is extraordinarily narrow (∼1 μm), suits the main applications of interest, microbeam radiation biology and microbeam radiation therapy (MRT). In MRT, micrometer-wide, centimeter-high, and vertically oriented swaths of tissue are irradiated by arrays of rectangular x-ray microbeams produced by a multislit collimator (MSC). We used MOSFETs to measure the dose distribution, produced by arrays of x-ray microbeams shaped by two different …

Solid State Diode - Ionization Chamber Method For Measuring Out-Of-Field Neutron Dose In Proton Therapy, Amy Ziebell, B Clasie, Andrew Wroe, Reinhard Schulte, Mark Reinhard, Stephen Dowdell, Michael Lerch, Marco Petasecca, V Perevertaylo, Oleg Zinets, Igor Anokhin, Anatoly Rosenfeld

Michael L.F. Lerch

In proton therapy neutrons are introduced to out-of-field regions inside the patient. Clinicians would like to know the absorbed dose being deposited by neutrons separately to that from protons, so as to be able to directly apply their own dose equivalent weighting factors based on their opinion of the biological risk posed by neutrons in this region. The purpose of this study is to investigate a novel approach to experimentally separating the proton and neutron contributions to the absorbed dose in out-of-field regions. The method pairs specially designed silicon PIN diodes with a standard clinical ionization chamber. The sensitivity of …

The Effect Of Rectal Heterogeneity On Wall Dose In High Dose Rate Brachytherapy, Ian Kwan, Dean Wilkinson, Dean Cutajar, Michael Lerch, Anatoly Rosenfeld, Andrew Howie, Joseph Bucci, Y. Chin, V. Perevertaylo

Michael L.F. Lerch

When treating prostate cancer using high dose rate (HDR) brachytherapy, overdosing the rectal wall may lead to post-treatment rectal complications. An area of concern is related to how the rectal wall dose is calculated by treatment planning systems (TPSs). TPSs are used to calculate the dose delivered to the rectal wall, but they assume that the rectum is a water-equivalent homogeneous medium of infinite size and do not consider the effect that an air-filled “empty” rectal cavity would have on the dose absorbed along the rectal wall. The aim of this research is to quantify the effect that an air …

Microbeam Radiation Therapy: A Monte Carlo Study Of The Influence Of The Source, Multislit Collimator, And Beam Divergence On Microbeams, Heidi Nettelbeck, George Takacs, Michael Lerch, Anatoly Rosenfeld

Michael L.F. Lerch

Microbeam radiation therapy (MRT) is a new oncology method currently under development for the treatment of inoperable pediatric brain tumors. Monte Carlo simulation, or the computational study of radiation transport in matter, is often used in radiotherapy to theoretically estimate the dose required for treatment. However, its potential use in MRT dose planning systems is currently hindered by the significant discrepancies that have been observed between measured and theoretical dose and the PVDR (peak to valley dose ratio). The need to resolve these discrepancies is driven by the desirability of making MRT available to humans in the next few years. …

In Vivo Verification Of Superficial Dose For Head And Neck Treatments Using Intensity-Modulated Techniques, Zhen-Yu Qi, Xiao-Wu Deng, Shao-Min Huang, Li Zhang, Zhi-Chun He, X. Allen Li, Ian Kwan, Michael Lerch, Dean Cutajar, Peter Metcalfe, Anatoly Rosenfeld

Michael L.F. Lerch

Skin dose is one of the key issues for clinical dosimetry in radiation therapy. Currently planning computer systems are unable to accurately predict dose in the buildup region, leaving ambiguity as to the dose levels actually received by the patient’s skin during radiotherapy. This is one of the prime reasons why in vivo measurements are necessary to estimate the dose in the buildup region. A newly developed metal-oxide-semiconductor-field-effect-transistor (MOSFET) detector designed specifically for dose measurements in rapidly changing dose gradients was introduced for accurate in vivo skin dosimetry. The feasibility of this detector for skin dose measurements was verified in …

Design And Simulation Of Scintillator-Pixel Photodetector With The Ability To Measure Position Of Interaction, George Takacs, Anatoly Rosenfeld, Michael Lerch, Philip Simmonds, Steven Meikle, G Taylor, V Perevertailo, S Eberl

Michael L.F. Lerch

No abstract provided.

Performance Comparison Of Two Compact Multiplexed Readouts With Sensl's Spmarray4 For High-Resolution Detector Module, Yujin Qi, Xiaohui Zhang, Cuilan Zhao, Lihong Chen, Marco Petasecca, Mitra Safavi-Naeini, Michael Lerch, Anatoly Rosenfeld

Michael L.F. Lerch

The purpose of this study was to investigate a compact readout for silicon photomultiplier (SiPM) array in the development of high-resolution imaging detector to reduce the readout channels while maximizing the detectors performance. The detector module was composed of a LYSO scintillation crystal array and a SensL's SPMArray4. The crystal array was coupled to the SiPM array with a 2mm-thick silicone pad to improve the light sharing among the SiPM array elements. Three LYSO crystal arrays of 4x4, 8x8 and 12x12 crystal elements with pixel sizes of 3.2, 1.6 and 1.0 mm were investigated in this study. Two compact multiplexed …

Dosimetry Of Intensive Synchrotron Microbeams, Michael Lerch, Marco Petasecca, A Cullen, A Hamad, H Requardt, E Brauer-Krisch, A Bravin, V Perevertaylo, Anatoly Rosenfeld

Michael L.F. Lerch

Intensive synchrotron X-ray microbeams form an integral part of microbeam radiation therapy (MRT). MRT is a novel radiation medicine modality being developed for inoperable and otherwise untreatable brain tumours. The extremely high dose rate (∼20 kGy/s), laterally fractionated radiation field and steep dose gradients utilized in this therapy make real-time dosimetry a significant challenge. In order for this treatment to advance to the clinical trial stage of development real-time dosimetry systems must be developed. This paper demonstrates the capabilities of a new dosimetry system based on an epitaxial silicon detector. The system combines high spatial resolution and real-time readout and …

Measurement Of Rectal Dose During Hdr Brachytherapy Using The New Moskin Dosimeter, Ian Kwan, Andrew Howie, Michael Lerch, Bong Soo Lee, Yaw Sinn Chin, Joseph Bucci, V Perevertaylo, Anatoly Rosenfeld

Michael L.F. Lerch

In HDR prostate brachytherapy, post-treatment complications occur due to overdosing the rectum wall and urethra. An area of concern regarding treatment is related to how the rectal wall dose is calculated using treatment planning systems. Treatment planning systems can calculate the dose delivered to the rectal wall, assuming that the rectum is filled with water equivalent material. This assumption is not always correct, as the rectum is emptied before treatment begins. The aim of this research is to quantify the difference in the dose measured in an ‘empty’ rectal phantom, and in a rectal phantom filled with water equivalent material. …

Verification Of The Plan Dosimetry For High Dose Rate Brachytherapy Using Metal-Oxide-Semiconductor Field Effect Transistor Detectors, Zhen-Yu Qi, Xiao-Wu Deng, Shao-Min Huang, Jie Lu, Michael Lerch, Dean Cutajar, Anatoly Rosenfeld

Michael L.F. Lerch

The feasibility of a recently designed metal–oxide–semiconductor field effect transistor (MOSFET) dosimetry system for dose verification of high dose rate (HDR) brachytherapy treatment planning was investigated. MOSFET detectors were calibrated with a 0.6 cm3 NE-2571 Farmer-type ionization chamber in water. Key characteristics of the MOSFET detectors, such as the energy dependence, that will affect phantom measurements with HDR 192Ir sources were measured. The MOSFET detector was then applied to verify the dosimetric accuracy of HDR brachytherapy treatments in a custom-made water phantom. Three MOSFET detectors were calibrated independently, with the calibration factors ranging from 0.187 to 0.215 cGy∕mV. A distance …

Miniature Semiconductor Detectors For In Vivo Dosimetry, Anatoly Rosenfeld, Dean Cutajar, Michael Lerch, George Takacs, Iwan Cornelius, M Yudelev, M Zaider

Michael L.F. Lerch

Silicon mini-semiconductor detectors are found in wide applications for in vivo personal dosimetry and dosimetry and microdosimetry of different radiation oncology modalities. These applications are based on integral and spectroscopy modes of metal oxide semiconductor field effect transistor and silicon p–n junction detectors. The advantages and limitations of each are discussed.

Monte Carlo Modelling Of A Silicon Strip Detector For Microbeam Radiation Therapy, Ashley Cullen, Michael Lerch, Marco Petasecca, Anatoly Rosenfeld

Michael L.F. Lerch

Microbeam radiation therapy is an experimental technique utilising synchrotron X-rays collimated into a planar array of microbeams. Due to the complex structure of the radiation field and high dose rate, this introduces dosimetric challenges. Current dosimetric methods are inadequate in that they lack either real-time readout, or high spatial resolution. A detector system, consisting of the Silicon Multi-Strip Detector and associated readout system was developed at the University of Wollongong. This system performs online, real-time dosimetry, and is designed for placement upstream of the patient as a transmission detector. The interaction of synchrotron radiation with this detector, both in terms …

Brachyview: A Novel In-Body Imaging System For Prostate Brachytherapy, Kevin Loo, Marco Petasecca, Mitra Safavi, Michael Lerch, Zhangbo Han, Jan Jakubek, Stanislav Pospisil, Steven Meikle, Marco Zaider, Joseph Bucci, Anatoly Rosenfeld

Michael L.F. Lerch

The dosimetric quality of seed implants is a crucial part of the prostate brachytherapy treatment procedure. Incorrect seed placement during or after deployment leads to both short and long term complications, including urethral and rectal toxicity. The BrachyView system is a fast intraoperative planning system, providing real-time dosimetric information by acting as an in-body gamma camera. It incorporates three tiled Medipix2 pixellated detectors coupled to a multi-pinhole collimator. Three-dimensional reconstructed images from multiple planar images are used to determine the seed placement in real time. The seed image, when fused with the ultrasound dataset, provides both anatomical and dosimetric information …

Skin Dosimetry With New Mosfet Detectors, Ian Kwan, Anatoly Rosenfeld, Zhen Yu Qi, Dean Wilkinson, Michael Lerch, Dean Cutajar, Mark Safavi-Naeini, Martin Butson, J Bucci, Y Chin, V Perevertaylo

Michael L.F. Lerch

The MOSkin, a new MOSFET-based detector designed by the Centre for Radiation Physics, was engineered to provide accurate measurements of skin doses in radiotherapy and personal monitoring. The International Commission on Radiological Protection (ICRP) estimates the radiosensitive basal layer to be at an average depth of 0.070 mm. Current commercially available MOSFETs utilize an epoxy bubble encapsulation, making measurements at equivalent depths of 0.070mm difficult. The MOSkin utilizes a novel packaging design that allows the measurement of doses at this equivalent depth. The MOSkin has shown excellent agreement with the Attix chamber for surface measurements in a 6MV photon beam …

Independent Quality Assurance Of A Helical Tomotherapy Machine Using The Dose Magnifying Glass, Jeannie Wong, Nick Hardcastle, Wolfgang Tome, A Bayliss, R Tolakanahalli, Michael Lerch, Marco Petasecca, Martin Carolan, Peter Metcalfe, Anatoly Rosenfeld

Michael L.F. Lerch

Purpose: Helical tomotherapy is a complex delivery technique, integrating CT image guidance and intensity modulated radiotherapy in a single system. The integration of the CT detector ring on the gantry not only allows patient position verification but is also often used to perform various QA procedures. This convenience lacks the rigor of a machine-independent QA process. Methods: In this article, a Si strip detector, known as the Dose Magnifying Glass (DMG), was used to perform machine-independent QA measurements of the multileaf collimator alignment, leaf open time threshold, and leaf fluence output factor (LFOF). Results: The DMG measurements showed good agreements …

Development Of A New Detector Module For Use In Positron Emission Tomography, Michael Lerch, Robert Ward, Philip Simmonds, Steven Meikle, Anatoly Rosenfeld, George Takacs, V Pervertailo, G Taylor

Michael L.F. Lerch

No abstract provided.