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Clinical Probe Utilizing Surface-Enhanced Raman Scattering (Sers) For In-Situ Molecular Imaging Applications, Jeonghwan Kim

LSU Doctoral Dissertations

In this research, a clinical probe utilizing Surface-Enhanced Raman Scattering (SERS) is developed for molecular imaging application which is a visualizing technology to support early diagnosis by providing images in molecular level. In addition to other molecular imaging applications using magnetic resonance, light, and ultrasound, Raman spectroscopy has great potential in terms of non-invasiveness, safety, imaging agent-free, and scanning multiple molecules at a time. However, the critical limitation of Raman spectroscopy using in-vivo molecular imaging application is the inherent low sensitivity of Raman effect. The challenge is overcome by employing SERS enhancing Raman scattering with concentrated electromagnetic oscillation in nanometallic …