Digital Commons Network^™

The Effect Of Αct-1 Peptide On Bone Marrow Stromal Cells Following Injury, Adam Clay Vandergriff

Theses and Dissertations

Connexin43 (Cx43) is a component of gap junctions and is involved in intercel- lular signaling following injury to tissues. The carboxyl terminus of Cx43 binds to the PDZ2 domain of ZO-1 in order to form gap junction plaques and connect to the cytoskeleton. A biomimetic peptide known as αCT-1, replicating the last 9 amino acids found in the carboxyl terminus of CX43, has been shown to improve wound healing by preferentially binding to the PDZ2 domain of ZO-1. A possible mecha- nism for its action is through the Epithelial-Mesenchymal Transformation (EMT). Scratch assays were performed on rat bone marrow stromal …

High Resistivity Amorphous Selenium Alloy Semiconductors For Radiation Detection Applications, Abhinav Mehta

Theses and Dissertations

High resolution noninvasive tools of diagnosis has always derived and enabled scientific and medical research to probe and better understand subtleties of matter, intangible to the human eye. Radiation detection systems are highly dependent on advancements in materials and devices with front-end electronics. There are various discrete applications of these radiation detectors and each application imposes certain requirements so there is no single optimum radiation detector.

Flat panel x-ray imagers have gained high demand in the past decade because of exponential improvement in readout electronics. We have synthesized and investigated stabilized amorphous selenium (a-Se) alloys suitable for high resolution flat …

Dislocation Reduction In Silicon Doped High Aluminum Content Algan Layers For Deep Uv Optoelectronic Devices, Hung-Chi Chen

Theses and Dissertations

III-Nitride based deep ultraviolet (UV) light emitting diodes (LEDs) are prospective candidates to replace the conventional bulky, expensive and environmentally harmful mercury lamp as new UV light sources, used in the applications of water and air purification, germicidal and biomedical instrumentation systems, etc. Due to the lack of native substrates and poor carrier injection, AlGaN-based deep UV LED is suffering from low optical power and low overall efficiency, which prevents the availability of low cost, high efficiency deep UV LED on the market.

This dissertation is focused on improving the efficiency of deep UV LEDs, by improving the base template …

Effects Of N-Type Doping On Algan Material Quality, Devendra Diwan

Theses and Dissertations

The field of group III-nitride semiconductors has seen incredible developments during last couple of decades. They are recognized as the most promising materials for a wide field of optoelectronics and electronic devices. Their bandgap ranges from 6.2 eV for AlN to 0.7 eV for InN, covering a wide spectral range from infrared (1.77 mm) to deep ultraviolet (200 nm). Their direct bandgap makes them useful for fabricating optoelectronic devices such as light emitting diodes (LEDs), laser diodes (LDs), and photodetectors. III-nitride semiconductor materials also possess strong bond strengths and exhibit good structural, chemical and thermal stability. These properties make it …

Ultrawideband (Uwb) And Reconfigurable Antennas - New Concepts For Conformal Load Bearing Antenna Structures (Clas), Nicholas Bishop

Theses and Dissertations

Conformal antennas have been increasingly playing an important role in a vast number wireless of communication applications. More specifically, Conformal Load Bearing Antenna Structures (CLAS) have drawn a great deal of interest among researchers and engineers because of their advantages of multiple functionality, e.g. antenna and structure both. The objectives of this thesis are to investigate and design innovative conformal Ultrawideband (UWB) endfire antenna arrays and reconfigurable aperture coupled pixel patch antennas both of which are good candidates for CLAS. First, a broadband VHF-UHF end-fire Yagi-Uda array is proposed for possible air vehicle integration and operation within the 240-465 MHz …

Fault Aware Soft Restart Of An Islanded Microgrid Using An Inverter Coupled Energy Storage System, Asif Anwar

Theses and Dissertations

This research developed a method for autonomous operation of an inverter-coupled energy storage system for safe islanding- re-energization - and reconnection of the facility-island or microgrid to the utility / distribution circuit in a seamless manner in the event of a fault. This enables the energy storage system to function as an autonomous source within the utility power distribution system without the need to re-engineer the existing protection coordination in the distribution system. Fault detection based on voltage measurements from the inverter terminals are used to detect a fault and isolate the energy storage-powered facility with negligible power feed into …

Crystal Growth, Characterization And Fabrication Of Cdznte-Based Nuclear Detectors, Ramesh Madhu Krishna

Theses and Dissertations

In today's world, nuclear radiation is seeing more and more use by humanity as time goes on. Nuclear power plants are being built to supply humanity's energy needs, nuclear medical imaging is becoming more popular for diagnosing cancer and other diseases, and control of weapons-grade nuclear materials is becoming more and more important for national security. All of these needs require high-performance nuclear radiation detectors which can accurately measure the type and amount of radiation being used. However, most current radiation detection materials available commercially require extensive cooling, or simply do not function adequately for high-energy gamma-ray emitting nuclear materials …

Walkcompass: Finding Walking Direction Leveraging Smartphone's Inertial Sensors, Nirupam Roy

Theses and Dissertations

Determining moving direction with smartphone's inertial sensors is a well known problem in the field of location service. Compass alone cannot solve this problem because smartphone's compass cannot achieve high accuracy. Moreover GPS is not suitable in indoor scenario. Another well known approach is dead-reckoning but dead-reckoning needs to know phones initial orientation and over time it keeps accumulating errors and after some time the estimation becomes to noisy to use. To overcome these limitations, we propose a solution called WalkCompass which is specially designed for pedestrians keeping in mind the variation of force during normal human walk. Therefore the …

Mass Spectrometry And Tandem Mass Spectrometry Characterization Of Protein Patterns, Protein Markers And Whole Proteomes For Pathogenic Bacteria, Jennifer Intelicato-Young

Theses and Dissertations

There have been many recent reviews published on MALDI-TOF MS (matrix assisted laser desorption/ionization time-of-flight) MS (mass spectrometry) for identification of bacteria particularly with relevance to clinical microbiology. MALDI-TOF MS is now a mature technique for bacterial identification with great promise. The purpose of this review is to put into perspective MALDI-TOF MS and other widely used mass spectrometry methods for characterization of proteins. MALDI-TOF MS is used for rapid determination of a mass pattern of proteins for bacterial characterization; these proteins

are generally not identified. Alternatively, after gel separation, MALDI TOF-TOF MSMS (tandem mass spectrometry) or on-line LC-ESI MS-MS …

Plc Code Vulnerabilities Through Scada Systems, Sidney E. Valentine, Jr.

Theses and Dissertations

Supervisory Control and Data Acquisition (SCADA) systems are widely used in automated manufacturing and in all areas of our nation's infrastructure. Applications range from chemical processes and water treatment facilities to oil and gas production and electric power generation and distribution. Current research on SCADA system security focuses on the primary SCADA components and targets network centric attacks. Security risks via attacks against the peripheral devices such as the Programmable Logic Controllers (PLCs) have not been sufficiently addressed.

Our research results address the need to develop PLC applications that are correct, safe and secure. This research provides an analysis of …

Fault Location In Power Networks Using Synchronized Phasor Measurements, Cuong Nguyen

Theses and Dissertations

Faults in electric power systems can lead to cascading power outages which cause tremendous loss to the economy and affect people’s lives. Technical reports of recent blackout events in the United States pointed out the lack of situational awareness as one of the main causes of widespread outages. Time synchronized phasor measurement is recommended as a technology that can improve the monitoring of power system condition. By knowing exactly where a fault occurs, necessary actions can be taken in a timely manner and thus, damage caused by that fault can be limited. In this thesis, first, a method for precise …

Impact Of Physical Activity In The Prevention Of Colorectal Cancer, Sarah Ashley Barnes

Theses and Dissertations

This review evaluates the current understanding of research on the impact of physical activity in the prevention of colorectal cancer. Current biological mechanisms implicated in physical activity and colorectal cancer risk reduction are blood glucose regulation, insulin sensitivity, leptin and adiponectin profiles, inflammation as well as secreted protein acidic and rich in cysteine (SPARC), an exercise induced myokine. Recent literature indicates that 30-60 minutes of moderate to vigorous activity a day is effective against colorectal cancer development, and there is convincing evidence of aerobic exercise as differently beneficial in recruiting mechanisms identified as preventative against colorectal cancer. This article provides …

Emulation Of An Aeroderivative Twin-Shaft Gas Turbine Engine Using An Ac Electric Motor Drive, Blanca A. Correa

Theses and Dissertations

This dissertation presents a method to use an electric motor to emulate the steady-state and transient shaft power characteristics of an aeroderivative twin-shaft turbine engine. Model-based control provides the framework for developing an aeroderivative twin-shaft engine emulation system. Criteria are developed to appropriately specify the motor and variable-speed drive, based on torque, power, and inertia. This method accounts for the difference in inertia between the engine and the emulating motor; it establishes for the first time the nominal and peak torque requirements of the machine and the peak power and current requirements of the electronic motor drive (inverter).

Our results …

Impedance Estimation Using Randomized Pulse Width Modulation And Power Converters, William M. Mccoy

Theses and Dissertations

With the adoption of technologies such as alternative energy production, DC power grids, and electric vehicles, the use of high power switching converters has seen a dramatic increase. These power converters serve many rolls such as grid-tied inverters in solar farms, high power charging for electric vehicles, motor drives for industrial applications, and DC links in transmission systems. With the increased prevalence of such devices, it is only natural to attempt to optimize their operation. As with any level of converter, it is desirable to have accurate control over the generated voltages and currents. Often, these controllers implement some form …

High Quality Silicon Carbide Epitaxial Growth By Novel Fluorosilane Gas Chemistry For Next Generation High Power Electronics, Tawhid Rana

Theses and Dissertations

High quality, thick (~100µm), low doped and low defect density SiC epitaxial films are essential for high voltage (blocking voltage >10kV), light, compact and reliable next generation power devices. One of the significant challenges in obtaining high quality thick SiC epitaxial films is to restrict/eliminate the Si gas-phase nucleation or aerosol formation during growth. The generated aerosol particles adversely influence growth by reducing the growth rate due to precursor losses, and also affect crystal quality, since the Si droplets are carried to the crystal growth surface. Moreover, liquid aerosol particles adhere to the various reactor parts (parasitic deposition), and contribute …

Development Of Proteomic Characterization And Speciation Techniques Utilizing Tryptic Peptides With Maldi-Tof Ms And Lc-Esi Ms-Ms, Jennifer Marie Kooken

Theses and Dissertations

The characterization of microbes which can be opportunists and pathogens (e.g., methicillin resistant Staphylococcus aureus (MRSA)) is important in understanding and potentially treating diseases caused by various bacterial species. Common genera found in the human skin micro-biome include Micrococcus and Staphylococcus, but there only a limited number of tests to differentiate these genera and/or species. My research reflects methods development from distinguishing one closely related genera from another and then expanded to species identification. Tryptic peptides were analyzed by MALDI TOF MS and the mass profiles compared with those of a reference strain in both genus and species identification. Aconitate …

Investigation Of Start Domain Proteins In Human Luteinized Cells And Cos-1 Cells, Bo Shi

Theses and Dissertations

After the luteinizing hormone surge of the menstrual cycle, the ovarian follicular granulosa and theca cells terminally differentiate to form the luteal cells of the corpus luteum. During this process known as luteinization, granulosa cells begin to synthesize large quantities of progesterone, a hormone essential for pregnancy. The rate limiting step for the de novo synthesis of pregnenolone (the precursor to progesterone) is the transport of cholesterol from the outer to the inner mitochondrial membrane, a process mediated by STARD1. STARD1 contains a C-terminal lipid binding domain holding one molecule of cholesterol, and an N-terminal domain targeting STARD1 to the …

3d Grain Segmentation In Superalloy Images Using Multichannel Edge-Weighted Centroidal Voronoi Tessellation Based Methods, Yu Cao

Theses and Dissertations

Accurate grain segmentation on 3D superalloy images is very important in materials science and engineering. From grain segmentation, we can derive the underlying superalloy grains' micro-structures, based on which many important physical, mechanical and chemical properties of the superalloy samples can be evaluated. However, grain segmentation is usually a very challenging problem since: 1) even a small 3D superalloy sample may contain hundreds of grains; 2) carbides and noises may degrade the imaging quality; and 3) the intensity within a grain may not be homogeneous. In addition, the same grain may present different appearances, i.e. intensities, under different microscope settings. …

Accelprint:Accelerometers Are Different By Birth, Sanorita Dey

Theses and Dissertations

This paper submits a hypothesis that smartphone accelerometers possess unique fingerprints. We believe that the fingerprints arise from hardware imperfections during the sensor manufacturing process, causing every sensor chip to respond differently to the same motion stimulus. The differences in responses are subtle enough that they do not affect most of the higher level functions computed on them. Nonetheless, upon close inspection, these fingerprints emerge with consistency, and can even be somewhat independent of the stimulus that generates them. Measurements and classification on 80 standalone accelerometer chips, 25 Android phones, and 2 tablets, show precision and recall upward of 96%, …

Accelerating Short Read Mapping Using A Dsp Based Coprocessor, Shaun I. Gause

Theses and Dissertations

Advances in next generation sequencing technologies have allowed short reads to be generated at an increasing rate, shifting the bottleneck of the sequencing process to the short read mapping computations. High costs and extended processing times drive researchers to pursue more efficient solutions with an overall goal of a short read mapping architecture capable of processing short reads as they are generated. Digital signal processors have shown high performance capabilities while maintaining low power consumption in a wide field of applications. This thesis explores the use of a DSP accelerated exact match short read mapping algorithm, focusing on a performance …

Multi-Label Segmentation Propagation For Materials Science Images Incorporating Topology And Interactivity, Jarrell Waggoner

Theses and Dissertations

Segmentation propagation is the problem of transferring the segmentation of an image to a neighboring image in a sequence. This problem is of particular importance to materials science, where the accurate segmentation of a series of 2D serial-sectioned images of multiple, contiguous 3D structures has important applications. Such structures may have prior-known shape, appearance, and/or topology among the underlying structures which can be considered to improve segmentation accuracy. For example, some materials images may have structures with a specific shape or appearance in each serial section slice, which only changes minimally from slice to slice; and some materials may exhibit …

Fault Protection In Dc Distribution Systems Via Coordinated Control Of Power Supply Converters And Bus Tie Switches, Pietro Cairoli

Theses and Dissertations

A new fault protection method responds to the current needs of emerging dc power distribution systems by coordinating electronic power converters and mechanical contactors to rapidly isolate short circuit faults while maintaining continuity of power to loads. This work is important because the increasing performance, higher efficiency, and decreasing cost of electronic power converters have spurred a rediscovery and proliferation of dc power distribution systems. Although dc distribution offers advantages such as higher transmission efficiency, higher power density, higher reliability, and ease of interfacing asynchronous sources, enthusiasm for adopting dc technologies suffers from widespread concern over the means to protect …

Analysis Of Modulation And Voltage Balancing Strategies For Modular Multilevel Converters, Ryan Blackmon

Theses and Dissertations

Modular multilevel converters are an emerging voltage source converter topology suitable for many applications. The increased utilization of HVDC power transmission solutions has resulted in modular multilevel converters becoming a more common converter type. Other applications include interfacing renewable energy power sources to the grid and motor drives. Modular multilevel converters are beneficial for medium voltage motor drives because the properties of this converter topology, such as low distortion, allow for an efficient motor drive design.

Modular multilevel converters are designed where instead of using 6 IGBTs as in a conventional voltage source converter, numerous low-rated IGBTs are used to …

Polyspectral Signal Analysis Techniques For Condition Based Maintenance Of Helicopter Drive-Train System, Mohammed Ahmed Hassan Mohammed

Theses and Dissertations

For an efficient maintenance of a diverse fleet of air- and rotorcraft, effective condition based maintenance (CBM) must be established based on rotating components monitored vibration signals.

In this dissertation, we present theory and applications of polyspectral signal processing techniques for condition monitoring of critical components in the AH-64D helicopter tail rotor drive train system. Currently available vibration-monitoring tools are mostly built around auto- and cross-power spectral analysis which have limited performance in detecting frequency correlations higher than second order. Studying higher order correlations and their Fourier transforms, higher order spectra, provides more information about the vibration signals which helps …

High Performance Rf Control Devices Using Capacitively Coupled Contacts (C3) Over Iii-N Heterostructures, Faisal Jahan

Theses and Dissertations

RF switches, power limiters and other control devices are essential components of modern RF systems. RF switches are important parts of wireless modules of various devices such as laptops, tablets, cell phones etc. and key components of satellites communication systems, radars, multi-band wireless and aerospace communications, phased array antennas. RF Power limiters (PL) are also important components of RF systems protecting linear amplifiers, detectors etc. from high-power stress. Traditionally, RF switches are fabricated using pin diodes or MEMS, Si MOSFETs or GaAs HEMTs. RF PLs are typically implemented using Schottky or pin-diodes. Traditional devices used in RF switch and PLs …

Wireless Pressure Sensor System For Medical Applications, Xuehe Wang

Theses and Dissertations

Telemedicine in the modern era is a rapidly developing industry. In a telemedicine system, sensor is the key elements and play important role in any telemedicine applications, especially implantable sensors. Unlike traditional in vitro sensors, there are some special requirements for them like battery-less, compact, and bio-friendly. Therefore, many researchers in institutes as well as in industry are continually developing implantable sensor and sensor system to fulfill the requirements of medical applications.Nine in one thousand people in the United States are born with congenital heart defects and sixty percent die before one year old. As a result, it will be …

Electromagnetic Modeling Of Gan Varactor Microwave Switches, Yi-Hsuan Yang

Theses and Dissertations

Microwave switches are important components which have been widely used in many microwave systems, such as electronic products, satellites communications, antennas, and radars etc. Traditionally, microwave switches are fabricated using pin diodes or MEMS, Si MOSFETs or GaAs HEMTs. These devices, due to the material limitations are suffering from a low breakdown voltage and are unable to handle high power. III-Nitride based varactor microwave switches provide opportunities for high power microwave devices, due to highly conducting 2D electron gas in the channel and high breakdown electric field.

Designing microwave switches typically involves modeling and simulation using tools such as MATLAB, …

Iii-V Nitride Micro- And Nano-Scale Cantilevers For Multimodal Sensing Applications, Ehtesham Bin Quddus

Theses and Dissertations

Recent research trends in chemical and biological sensing have been geared toward developing molecular sensor devices that are fast, label free, miniaturized and portable. The performance of these devices can be dramatically improved by utilizing multimodal detection techniques, new materials and micro-/nanofabrication technologies. This is especially true for micro-/nanoscale cantilever sensors, which undergo changes in mechanical or electrical properties upon the specific binding of molecules. To develop the sensor devices with the above attributes, we utilized III-V nitride materials: InN nanowires for realizing nanoscale cantilevers and AlGaN/GaN heterostuctures with or without embedded HFETs, for developing microcantilevers. There are mainly two …

Stabilizing Controller Design For A Dc Power Distribution System Using A Passivity-Based Stability Criterion, Antonino Riccobono

Theses and Dissertations

In modern times there has been an increased penetration of power electronic converters into Power Distribution Systems. In particular, there has been a strong interest in DC Power Distribution Systems as opposed to conventional AC Power distribution systems. These DC Power Distribution Systems are enabled by power electronics converters. The strong interest is motivated by improvements in power electronic converter technology, like advances in power semiconductor devices, magnetics, control, and converter topologies which have made possible to build high-performance converters at low cost. In many systems, such as cars, ships and airplanes, there has also been a trend towards the …

The Anti-Angiogenic Effects Of Sparstolonin B, Henry Rhodes Bateman

Theses and Dissertations

Sparstolonin B (SsnB) is a novel bioreactive compound isolated from Sparganium stoloniferum, an herb historically used in Traditional Chinese Medicine as an anti-tumor agent. SsnB has demonstrated anti-inflammatory properties, inhibiting Toll-like receptor mediated inflammation in isolated macrophages and in mice. Angiogenesis, the process of new capillary formation from existing blood vessels, is dysregulated in many pathological disorders, including atherosclerosis, diabetic retinopathy, and tumor growth. The goal of the project was to investigate the anti-angiogenic effects of SsnB.

The first part of the project utilized in vitro functional assays to study how SsnB affected endothelial cells. SsnB inhibited endothelial cell tube …