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Expression Of Kallikrein-Related Peptidases (Klks) In Adenoid Cystic Carcinoma, Zachary R. Kerr
Expression Of Kallikrein-Related Peptidases (Klks) In Adenoid Cystic Carcinoma, Zachary R. Kerr
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Adenoid cystic carcinoma (ACC) of salivary glands is a malignancy known for its slow growth pattern, but poor long-term survival despite aggressive treatment. This highlights the need for an improved approach to its management.
It has been suggested that kallikrein-related peptidases (KLKs), a group of 15 serine proteases, may serve as biomarkers for salivary gland tumors. KLKs are involved in numerous biological processes and have been linked to several cancers.
This study evaluated KLK gene expression in ACC and normal salivary gland tissue (NSGT). Total RNA was isolated from 40 formalin-fixed, paraffin-embedded samples, which included 25 ACCs and 15 NSGTs. …