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Lmcrot: An Enhanced Protein Crotonylation Site Predictor By Leveraging An Interpretable Window-Level Embedding From A Transformer-Based Protein Language Model, Pawel Pratyush, Soufia Bahmani, Suresh Pokharel, Hamid D. Ismail, Dukka Bahadur Apr 2024

Lmcrot: An Enhanced Protein Crotonylation Site Predictor By Leveraging An Interpretable Window-Level Embedding From A Transformer-Based Protein Language Model, Pawel Pratyush, Soufia Bahmani, Suresh Pokharel, Hamid D. Ismail, Dukka Bahadur

Michigan Tech Publications, Part 2

MOTIVATION: Recent advancements in natural language processing have highlighted the effectiveness of global contextualized representations from Protein Language Models (pLMs) in numerous downstream tasks. Nonetheless, strategies to encode the site-of-interest leveraging pLMs for per-residue prediction tasks, such as crotonylation (Kcr) prediction, remain largely uncharted. RESULTS: Herein, we adopt a range of approaches for utilizing pLMs by experimenting with different input sequence types (full-length protein sequence versus window sequence), assessing the implications of utilizing per-residue embedding of the site-of-interest as well as embeddings of window residues centered around it. Building upon these insights, we developed a novel residual ConvBiLSTM network designed …


Optimal Molecular Dynamics System Size For Increased Precision And Efficiency For Epoxy Materials, Khatereh Kashmari, Sagar Patil, Josh Kemppainen, Shankara Gowtham, Gregory Odegard Apr 2024

Optimal Molecular Dynamics System Size For Increased Precision And Efficiency For Epoxy Materials, Khatereh Kashmari, Sagar Patil, Josh Kemppainen, Shankara Gowtham, Gregory Odegard

Michigan Tech Publications, Part 2

Molecular dynamics (MD) simulation is an important tool for predicting thermo-mechanical properties of polymer resins at the nanometer length scale, which is particularly important for efficient computationally driven design of advanced composite materials and structures. Because of the statistical nature of modeling amorphous materials on the nanometer length scale, multiple MD models (replicates) are typically built and simulated for statistical sampling of predicted properties. Larger replicates generally provide higher precision in the predictions but result in higher simulation times. Unfortunately, there is insufficient information in the literature to establish guidelines between MD model size and the resulting precision in predicted …


The Microverse: A Task-Oriented Edge-Scale Metaverse, Qian Qu, Mohsen Hatami, Ronghua Xu, Deeraj Nagothu, Yu Chen, Xiaohua Li, Erik Blasch, Erika Ardiles-Cruz, Genshe Chen Feb 2024

The Microverse: A Task-Oriented Edge-Scale Metaverse, Qian Qu, Mohsen Hatami, Ronghua Xu, Deeraj Nagothu, Yu Chen, Xiaohua Li, Erik Blasch, Erika Ardiles-Cruz, Genshe Chen

Michigan Tech Publications, Part 2

Over the past decade, there has been a remarkable acceleration in the evolution of smart cities and intelligent spaces, driven by breakthroughs in technologies such as the Internet of Things (IoT), edge–fog–cloud computing, and machine learning (ML)/artificial intelligence (AI). As society begins to harness the full potential of these smart environments, the horizon brightens with the promise of an immersive, interconnected 3D world. The forthcoming paradigm shift in how we live, work, and interact owes much to groundbreaking innovations in augmented reality (AR), virtual reality (VR), extended reality (XR), blockchain, and digital twins (DTs). However, realizing the expansive digital vista …


The Integration Of Neuromorphic Computing In Autonomous Robotic Systems, Md Abu Bakr Siddique Jan 2024

The Integration Of Neuromorphic Computing In Autonomous Robotic Systems, Md Abu Bakr Siddique

Dissertations, Master's Theses and Master's Reports

Deep Neural Networks (DNNs) have come a long way in many cognitive tasks by training on large, labeled datasets. However, this method has problems in places with limited data and energy, like when planetary robots are used or when edge computing is used [1]. In contrast to this data-heavy approach, animals demonstrate an innate ability to learn by communicating with their environment and forming associative memories among events and entities, a process known as associative learning [2-4]. For instance, rats in a T-maze learn to associate different stimuli with outcomes through exploration without needing labeled data [5]. This learning paradigm …


Multispectral Deep Neural Network Fusion Method For Low-Light Object Detection, Keval Thaker, Sumanth Chennupati, Nathir Rawashdeh, Samir A. Rawashdeh Jan 2024

Multispectral Deep Neural Network Fusion Method For Low-Light Object Detection, Keval Thaker, Sumanth Chennupati, Nathir Rawashdeh, Samir A. Rawashdeh

Michigan Tech Publications, Part 2

Despite significant strides in achieving vehicle autonomy, robust perception under low-light conditions still remains a persistent challenge. In this study, we investigate the potential of multispectral imaging, thereby leveraging deep learning models to enhance object detection performance in the context of nighttime driving. Features encoded from the red, green, and blue (RGB) visual spectrum and thermal infrared images are combined to implement a multispectral object detection model. This has proven to be more effective compared to using visual channels only, as thermal images provide complementary information when discriminating objects in low-illumination conditions. Additionally, there is a lack of studies on …


Integrating Arcgis And Redux Using Middleware, Vishnu Vardhan Reddy Rapuru Jan 2024

Integrating Arcgis And Redux Using Middleware, Vishnu Vardhan Reddy Rapuru

Dissertations, Master's Theses and Master's Reports

The integration of ArcGIS with Redux through middleware presents a novel approach to managing state in geospatial applications. This report outlines the process and benefits of combining ArcGIS’s robust mapping and analytics capabilities with Redux’s predictable state container for JavaScript apps. It begins with an introduction to both technologies, followed by a detailed discussion on the architecture design, focusing on the role of middleware as the linchpin in this integration[1]. The paper highlights the benefits, such as improved state management and application performance, and addresses the challenges encountered during the integration process. Implementation details are provided, including the setup of …


Applications Of Independent And Identically Distributed (Iid) Random Processes In Polarimetry And Climatology, Dan Kestner Jan 2024

Applications Of Independent And Identically Distributed (Iid) Random Processes In Polarimetry And Climatology, Dan Kestner

Dissertations, Master's Theses and Master's Reports

The unifying theme of this thesis is the characterization of “perfect randomness,” i.e., independent and identically distributed (IID) stochastic processes as these are applied in physical science. Two specific and mathematically distinct applications are chosen: (i) Radar and optical polarimetry; (ii) Analysis of time series in meteorology. In (i), IID process of a special kind, namely, with a distribution defined by symmetry, is used to link its multivariate Gaussian density to uniformity on the Poincaré sphere. This “statistical ellipsometry” approach is then used to relate polarimetric mismatches or imbalances to ellipsometric variables and suitably chosen cross-correlation measures. In (ii), recently …


Optimizing Php Api Calls With Pagination And Caching, Parsharam Reddy Sudda Jan 2024

Optimizing Php Api Calls With Pagination And Caching, Parsharam Reddy Sudda

Dissertations, Master's Theses and Master's Reports

The Keweenaw Time Traveler (KeTT) project is devoted to mapping the historical and social landscapes of the Keweenaw Peninsula. During the project, it was discovered that the server-side performance needed improvement. To address this issue, the "Optimizing PHP API Calls with Pagination and Caching" initiative was launched. This initiative focused on refining API calls, implementing server caching and pagination, and fortifying security against common vulnerabilities. The project successfully mitigated risks associated with SQL Injection and XSS through meticulous code enhancements while improving error handling. Additionally, the introduction of Scroll-Induced Pagination optimized data delivery, significantly reducing response times, and elevating the …