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Quantitative Susceptibility Mapping (Qsm) Reconstruction From Mri Phase Data, Sara Gharabaghi

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Quantitative susceptibility mapping (QSM) is a powerful technique that reveals changes in the underlying tissue susceptibility distribution. It can be used to measure the concentrations of iron and calcium in the brain both of which are linked with numerous neurodegenerative diseases. However, reconstructing the QSM image from the MRI phase data is an ill-posed inverse problem. Different methods have been proposed to overcome this difficulty. Still, the reconstructed QSM images suffer from streaking artifacts and underestimate the measured susceptibility of deep gray matter, veins, and other high susceptibility regions. This thesis proposes a structurally constrained Susceptibility Weighted Imaging and Mapping …