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Auditory And Somatosensory Pre-Pulse Inhibition In Mice, Anna Louthan
Auditory And Somatosensory Pre-Pulse Inhibition In Mice, Anna Louthan
Dissertations, 2014-2019
Both hearing and somatosensation are sensory responses to vibrations, and here we show a way to investigate such mechanoreceptive psychophysics alone and in combination. Pre-pulse inhibition (PPI) is a well-known, unconditioned, and reflexive technique for measuring sensory thresholds with a wide variety of stimuli and laboratory animals. In this paper, we explore interactions between auditory and somatosensory PPI in normal mice. Fifteen C57/BL6J mice were tested three times each. Ages varied between one and six months. Testing followed published procedures from our lab and others, except the pre-pulses were auditory, somatosensory (vibration of the test chamber), or both. The auditory …
Hearing Studies In Old Mice: The Effect Of Pre-Pulse Inhibition On The Acoustic Startle Response, Ashley B. Hillyard, Nicolette S. Chuss
Hearing Studies In Old Mice: The Effect Of Pre-Pulse Inhibition On The Acoustic Startle Response, Ashley B. Hillyard, Nicolette S. Chuss
Senior Honors Projects, 2010-2019
The purpose of this study pertains to hearing in the species Peromyscus maniculatus (deer mice) — specifically their responses to a startling sound. Approximately seven mice were tested between four and five years of age, approaching the lifespan of this species. By means of an accelerometer, which measures a reflexive, motor response, the mice were presented with an acoustic startle-eliciting stimulus (SES) — that is a loud, startling, unexpected sound. During the study, the mice were also presented with a softer, less-intense stimulus — known as a pre-pulse — slightly before the more intense sound. This pre-pulse stimulus was in …
Pre-Pulse Inhibition Assessment Of Sound Localization In Mice: Methodological, Functional, And Genetic Considerations, Megan Klingenberg
Pre-Pulse Inhibition Assessment Of Sound Localization In Mice: Methodological, Functional, And Genetic Considerations, Megan Klingenberg
Dissertations, 2014-2019
Sound localization is an important aspect of normal hearing. The Eph/ephin family of signaling proteins, studied here, is known to guide the formation of central auditory connections in early development, particularly topographic inputs from the lateral superior olive (LSO) to the inferior colliculus (IC). Processing in the LSO and its influences on the IC are known to be heavily involved in sound localization tasks. One way to study sound localization in mice is through pre-pulse inhibition (PPI). PPI is the phenomenon by which a weak prestimulus inhibits the response to a subsequent startle stimulus. In studying sound localization, the prestimulus …