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The Role Of Histone Demethylases In Learning And Memory In The Mushroom Body Of Drosophila Melanogaster, Crystal Keung
The Role Of Histone Demethylases In Learning And Memory In The Mushroom Body Of Drosophila Melanogaster, Crystal Keung
Electronic Thesis and Dissertation Repository
Intellectual disability (ID) is a neurodevelopmental disorder associated with many epigenetic regulators and chromatin modifying enzymes like histone lysine methyltransferases (KMTs) and demethylases (KDMs). Here, I systematically investigate the role of 7 KDMs: Su(var)3-3, KDM2, Lid, CG2982, UTX, KDM4B, JHDM2, and 1 KMT: trr in the context of learning and memory using Drosophila melanogaster. Genetic knockdown of each gene in the mushroom body (MB) of flies are tested for short- and long-term memory impairment using courtship conditioning. Knockdown of 6 KDMs and trr resulted in memory loss. MB morphology was analyzed to determine potential cause of memory loss. …
Mechanisms Involved In The Assessment Of Cumulative Long-Term Familiarity Of Object Concepts: An Erp Study, Haopei Yang
Mechanisms Involved In The Assessment Of Cumulative Long-Term Familiarity Of Object Concepts: An Erp Study, Haopei Yang
Electronic Thesis and Dissertation Repository
We investigated the sensitivity of ERP components implicated in recognition memory to degree of experimentally controlled and lifetime cumulative exposures during explicit memory judgements. A parietally distributed ERP component spanning both the FN400/N400 and the LPC time windows tracked both types of judgements. This effect appears to be an LPC effect with an early onset, and differs from previously reported effects of repetition linked to implicit memory. Based on recent evidence, we interpreted it as response-related evidence accumulation processes that are in line with both single-process models and continuous dual-process models. We also observed more positive ERPs in the left …
Category-Specific Item Recognition And The Medial Temporal Lobe, Christopher B. Martin
Category-Specific Item Recognition And The Medial Temporal Lobe, Christopher B. Martin
Electronic Thesis and Dissertation Repository
Much neuropsychological and neuroimaging research has been focused on the contributions of different medial temporal lobe (MTL) structures to recognition memory. The majority of these studies have linked perirhinal cortex (PrC) to item recognition, whereas the hippocampus and parahippocampal cortex (PhC) have primarily been associated with the recollection of contextual detail pertaining to a specific prior stimulus encounter. Here, I report results from three fMRI studies that examined the neural correlates of item recognition with a specific focus on the relationship between such signals and category-specific effects in the MTL. In Chapter 2, I reveal that category-specific representations in both …
Contribution Of Trpm2 To Memory Loss In An Alzheimer's Mouse Model, Megan M. Chen
Contribution Of Trpm2 To Memory Loss In An Alzheimer's Mouse Model, Megan M. Chen
Electronic Thesis and Dissertation Repository
Alzheimer’s disease (AD) is a neurodegenerative disease characterized by the progressive deterioration of memory and other intellectual abilities. Accumulation of amyloid-β (Aβ) peptide, the major contributor to the senile plaques central to AD, is thought to mediate neurotoxicity by inducing oxidative stress and calcium dysregulation. Transient Receptor Potential Melastatin type 2 (TRPM2) is a calcium permeable, non-selective cation channel activated under oxidative stress and ultimately induces cell death. The APPSWE/PSEN1ΔE9 double transgenic mouse model carries the human APPswe (Swedish mutations K594N/M595L) and PS1 mutations with a deletion in exon 9 (PS1-dE9), and is one of the most commonly used AD …