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Gene-Environment Interactions In Attention Deficit Hyperactivity Disorder, Holly Donovan Barnard
Gene-Environment Interactions In Attention Deficit Hyperactivity Disorder, Holly Donovan Barnard
Electronic Theses and Dissertations
The overall goal of this project is to advance our understanding of the multifactorial etiology of Attention Deficit Hyperactivity Disorder (ADHD) by testing a diathesis-stress model of gene x environment (g x e) interactions. Although the literature increasingly supports g x e interactions in the manifestation of ADHD, few studies have investigated multiple genetic and environmental risk factors, included direct tests of gene - environment correlations (rG-Es), explored the specificity of interactions to symptom dimensions, or attempted to minimize comparisons. Therefore, utilizing both within-family (FBAT/PBAT) and case-control methodology, this study sought to (1) explore main effects of polymorphisms in the …
Gene X Environment Interactions In Developmental Dyslexia, Lauren M. Mcgrath
Gene X Environment Interactions In Developmental Dyslexia, Lauren M. Mcgrath
Electronic Theses and Dissertations
The goal of this project was to advance understanding of the complex multifactorial etiology of developmental dyslexia, or reading disability (RD), by investigating gene x environment (G x E) interactions. This project tested for G x E interactions using molecular genetic methods and measures of psychosocial and bioenvironmental risk factors. There are two competing predictions that can be derived from existing G x E models about the expected direction of interactions in RD. There could be "diathesis-stress" interactions in which the effects of genotype are stronger in risk environments, or there could be "bioecological" interactions in which the effects of …
Mitigating Risk For Anxiety Among Preschool-Age Children Living In Poverty: Evaluating The Impact Of Adult-Provided Social Support On Autonomic Stress Reactivity, Brian Cory Wolff
Mitigating Risk For Anxiety Among Preschool-Age Children Living In Poverty: Evaluating The Impact Of Adult-Provided Social Support On Autonomic Stress Reactivity, Brian Cory Wolff
Electronic Theses and Dissertations
Poverty increases children's exposure to stress, elevating their risk for developing patterns of heightened sympathetic and parasympathetic stress reactivity. Repeated patterns of high sympathetic activation and parasympathetic withdrawal place children at risk for anxiety disorders. This study evaluated whether providing social support to preschool-age children during mildly stressful situations helps reduce reactivity, and whether this effect partly depends on children's previously assessed baseline reactivity patterns. The Biological Sensitivity to Context (BSC) theory proposes that highly reactive children may be more sensitive than less reactive children to all environmental influences, including social support. In contrast, conventional physiological reactivity (CPR) theory contends …