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Mechanisms Of Virus Mitigation And Suitability Of Bacteriophages As Surrogates In Drinking Water Treatment By Iron Electrocoagulation, Joe Heffron, Brad Mcdermid, Emily Maher, Patrick J. Mcnamara, Brooke K. Mayer
Mechanisms Of Virus Mitigation And Suitability Of Bacteriophages As Surrogates In Drinking Water Treatment By Iron Electrocoagulation, Joe Heffron, Brad Mcdermid, Emily Maher, Patrick J. Mcnamara, Brooke K. Mayer
Civil and Environmental Engineering Faculty Research and Publications
Emerging water treatment technologies using ferrous and zero-valent iron show promising virus mitigation by both inactivation and adsorption. In this study, iron electrocoagulation was investigated for virus mitigation in drinking water via bench-scale batch experiments. Relative contributions of physical removal and inactivation, as determined by recovery via pH 9.5 beef broth elution, were investigated for three mammalian viruses (adenovirus, echovirus, and feline calicivirus) and four bacteriophage surrogates (fr, MS2, P22, and ΦX174). Though no one bacteriophage exactly represented mitigation of the mammalian viruses in all water matrices, bacteriophage ΦX174 was the only surrogate that showed overall removal comparable to that …
Bacteriophage Inactivation As A Function Of Ferrous Iron Oxidation, Joe Heffron, Brad Mcdermid, Brooke K. Mayer
Bacteriophage Inactivation As A Function Of Ferrous Iron Oxidation, Joe Heffron, Brad Mcdermid, Brooke K. Mayer
Civil and Environmental Engineering Faculty Research and Publications
Iron-based disinfection has been promoted as a potential low-cost, low-byproduct means of virus mitigation. This research is the first to establish that virus inactivation due to ferrous iron is impacted both by the extent of iron oxidation (from ferrous to ferric iron) and the rate of iron oxidation. Log inactivation of bacteriophages increased linearly with ferrous iron concentration at low doses (< 3 mg/L Fe), but higher doses limited disinfection, likely due to floc formation. The rate of iron oxidation was controlled by independently varying pH and dissolved oxygen concentration. Bacteriophage inactivation increased with the inverse of ferrous oxidation rate, suggesting that slower iron oxidation rates allow better contact between viruses and reactive ferrous iron. Ferrous iron showed potential for disinfection in conditions of low pH and dissolved oxygen, though these conditions preclude effective iron coagulation/flocculation.
Emerging Investigators Series: Virus Mitigation By Coagulation: Recent Discoveries And Future Directions, Joe Heffron, Brooke K. Mayer
Emerging Investigators Series: Virus Mitigation By Coagulation: Recent Discoveries And Future Directions, Joe Heffron, Brooke K. Mayer
Civil and Environmental Engineering Faculty Research and Publications
Waterborne viruses are widespread and persistent in the environment. Coagulation is an effective process for mitigating viruses in drinking water. This review examines recent studies of virus mitigation by coagulation processes in the context of the latest scientific advances. Virus sorption is impacted by electrostatic forces, as well as the hydrophobic effect, steric hindrance, hydrodynamics and interactions with the water matrix. Organic matter in the water may hinder or enhance sorption, depending on virus structure and environmental factors. In addition to physical separation in flocs, coagulation processes have been shown to inactivate viruses. This review evaluates reports of virus inactivation …
The Impact Of Capsid Proteins On Virus Removal And Inactivation During Water Treatment Processes, Brooke K. Mayer, Yu Yang, Daniel Gerrity, Morteza A. Abbaszadegan
The Impact Of Capsid Proteins On Virus Removal And Inactivation During Water Treatment Processes, Brooke K. Mayer, Yu Yang, Daniel Gerrity, Morteza A. Abbaszadegan
Civil and Environmental Engineering Faculty Research and Publications
This study examined the effect of the amino acid composition of protein capsids on virus inactivation using ultraviolet (UV) irradiation and titanium dioxide photocatalysis, and physical removal via enhanced coagulation using ferric chloride. Although genomic damage is likely more extensive than protein damage for viruses treated using UV, proteins are still substantially degraded. All amino acids demonstrated significant correlations with UV susceptibility. The hydroxyl radicals produced during photocatalysis are considered nonspecific, but they likely cause greater overall damage to virus capsid proteins relative to the genome. Oxidizing chemicals, including hydroxyl radicals, preferentially degrade amino acids over nucleotides, and the amino …