Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 4 of 4
Full-Text Articles in Entire DC Network
Transport Properties Of Nanometer-Sized Assemblies Through Nanofluidic Channels With Single Entity Electrical Detection, Franklin Ifeanyichukwu Uba
Transport Properties Of Nanometer-Sized Assemblies Through Nanofluidic Channels With Single Entity Electrical Detection, Franklin Ifeanyichukwu Uba
LSU Master's Theses
Recently, there have been reports on biological and solid-state nanopores that identify single biopolymers or their constituent monomers by analyzing changes in ionic current blockades when they block the flux of buffer ions while travelling through the nanopores. Nevertheless, there have been several limitations in their application, especially as DNA detectors; Poor confinement of the DNA strand within the nanopore (~0.1 % of a 10 kilobase (kb) DNA), poor signal sensitivity and random motion experienced by the DNA in solution that results in a large amount of noise in the signal. These have led to the development of nanochannel-based devices, …
Cure-On Demand Wood Adhesives Using Frontal Polymerization Of Acrylates, Treyvon Holt
Cure-On Demand Wood Adhesives Using Frontal Polymerization Of Acrylates, Treyvon Holt
LSU Master's Theses
Frontal polymerization (FP) is when the monomer is polymerized by a zone of reaction propagating through the monomer. The reaction zone is fueled by the heat given off by the polymerization of the monomer. FP is a promisig method for curing adhesives because it allows for cure-on-demand and fast cure times. The monomers selected for the adhesive is the main factor in determining the adhesive’s properties. Trimethylolpropane triacrylate (TMPTA), pentaerythritol tetraacrylate (PETA), and other multifunctional monomers make the polymer formed more brittle. The brittleness can be reduced by using trimethylolpropane ethoxylate triacrylates (TMPEOTA) in the place of the other multifunctional …
Selection And Enumeration Of Low Epcam Expressing Breast Cancer Ctcs Using A High Throughput Microfluidic Device, Brandy Charon Snowden
Selection And Enumeration Of Low Epcam Expressing Breast Cancer Ctcs Using A High Throughput Microfluidic Device, Brandy Charon Snowden
LSU Master's Theses
Breast cancer cells overexpress EpCAM that can be used as a marker to select breast cancer CTCs from heterogeneous clinical samples, even when present in low abundance. This study used MDA-MB-231 cells which have a low expression level of EpCAM (1.7 x 103 binding sites per cell.3) Herein, we will report on the use of antiEpCAM antibodies immobilized onto the surface of a capture bed poised within a PMMA microchip that was fabricated into an HTMSU used for selection of breast cancer CTCs seeded into a buffer solution. The microchannel walls within the capture bed were UV modified for 5, …
Single-Molecule Detection And Microfluidics: Generating Systems For The In Vitro Diagnostics Of Stroke, Brandon M. Young
Single-Molecule Detection And Microfluidics: Generating Systems For The In Vitro Diagnostics Of Stroke, Brandon M. Young
LSU Master's Theses
There is currently no available molecular diagnostic test for stroke; the common modality for diagnosis consists of computed tomography or magnetic resonance imaging. Unfortunately, the use of these diagnostic regimens can delay proper therapeutic treatment, which requires administration within the first 3 h of a stroke event. We are developing a molecular assay that can report, in near real time and at the point-of-care, the presence or absence of biomarkers specifically targeted for the diagnosis of ischemic or hemorrhagic stroke. The proposed strategy uses blood-borne mRNAs that are either under-expressed or over-expressed as a result of tissue damage within the …