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Nickel Catalyzed Cyclizations Of Alkynyl-Etones And Their Application To The Formal Synthesis Of Pentalenic Acid, Kevin Schlosser
Nickel Catalyzed Cyclizations Of Alkynyl-Etones And Their Application To The Formal Synthesis Of Pentalenic Acid, Kevin Schlosser
Honors Theses
Pentalenic acid is a very important molecule because it is a biosynthetic intermediate of pentalenolactone, which has antibiotic effects on Grampositive/ negative bacteria and pathogenic fungi. These effects are due to its ability to inhibit glyceraldehyde 3-phosphate dehydrogenase.1 However, the total synthesis of pentalenic acid is very lengthy.2 This project will begin the process of finding a more convenient route to pentalenic acid. Previously in this laboratory there have been experiments conducted in the cyclization of enones with nickel (0)3 It is hypothesized that this method can be used to shorten the preparation of pentalenic acid. As illustrated by the …