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Synthetic Methods Development Towards The Total Synthesis Of Chlorosulfolipids, Andres Villalpando
Synthetic Methods Development Towards The Total Synthesis Of Chlorosulfolipids, Andres Villalpando
LSU Doctoral Dissertations
The focus of this dissertation is the development of a novel chlorination reaction utilizing a triphosgene-amine based mixture towards the total synthesis of chlorosulfolipids, a subclass of naturally occurring organohalogen natural products. This novel, mild chlorination reaction will be utilized under a global chlorination strategy to chlorinate multiple alcohol substituents in one synthetic operation. Chapter one details the history of chlorosulfolipids from the early stages of their isolation, relevant structural elucidation techniques, appropriate biosynthetic discoveries, and their biological relevance to a thorough investigation of the total syntheses completed to date. These compounds demonstrate a range of biological activities and have …