Digital Commons Network^™

Chemical Investigations Of Diabetes Mellitus, Malaria, And Castrate-Resistant Prostate Cancer, Maggie Sparks Lookadoo

Masters Theses

This work studies a variety of molecules and the systems they are involved in to further understand disease and treatment of diabetes mellitus, malaria, and castrate resistant prostate cancer. The first system studied, diabetes mellitus, involves synthesis of 5 different steroidal compounds, while the other two systems, malaria and castrate-resistant prostate cancer, apply mass spectrometric-based untargeted metabolomics to study both known metabolites and unknown spectral features.

Diabetes mellitus is a result of the dysfunction and death of islet beta cells caused by the transcription of pro-inflammatory cytokines resulting in reduced insulin secretion and uncontrollable blood glucose levels. Glucocorticoids can reduce …