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Synthesis And 1H-Nmr Characterization Of Amphiphilic Acrylate Block Copolymers To Investigate The Effect Of Chain Rigidity On Micelle Formation In Solution, David Arnold

Master's Theses and Doctoral Dissertations

Amphiphilic block copolymers are composed of distinct segments exhibiting different chemical properties. In solution, block copolymers may self-assemble to form micelles when triggered by a change in the environment. The effect of chain rigidity can be investigated in better detail if the molecular weights are controlled, as the polymer’s ability to aggregate is also influenced by polymer size. Acrylate and methacrylate monomers were chosen for their similar chemical properties but their difference in reported glass transition temperature (T_g) ¹H-NMR methods were developed to measure molecular weight of poly(methyl methacrylate) and poly(t-butyl acrylate) homopolymers to corroborate size-exclusion …

Synthesis, Characterization, And Evaluation Of A Heat Stabilizing Siloxane, Joel D. Kennard

Master's Theses and Doctoral Dissertations

Siloxanes, renowned for their heat resistance and release properties, are prone to oxidize above 200°C. The goal herein is to increase siloxane bath life used in fuser roll applications at temperatures above 200°C, yielding faster production, less waste, and cost savings by keeping the bath viscosity stable through prevention of thermal degradation.

The methods detailed herein react a hydrosiloxane with an amino functional alcohol (4-(phenylamino)-phenol). The alcoholysis (or dehydrogenative coupling) moves forward with the removal of hydrogen and formation of the desired product (Scheme 1). Reactions were conducted on both NMR scale and lab scale.

The results of the synthesis …

Chemiluminescent Reactions Catalyzed By Nanoparticles Of Gold, Silver, And Gold/Silver Alloys, Saqib Ul Abideen

Master's Theses and Doctoral Dissertations

Chemiluminescence (CL) reactions are catalyzed by metals nanoparticles, which display unique catalytic properties due to an increased surface area. The present study describes the catalytic effects of nanoparticles (NP) of silver, gold, and alloys of Au/Ag nanoparticles on the chemiluminescent reaction taking place between luminol and potassium ferricyanide. It was found that silver nanoparticles and alloy nanoparticles enhance the CL process when their sizes remained in the range of 30 nm to 50 nm. The data show that the intensity and rate of chemiluminescence were influenced by the mole fraction of gold and silver in the alloy. Data to this …

Progress Towards Heterocycles As Inhibitors Of Plasminogen Activator Inhibitor-1, Gregory Alan Abernathy

Master's Theses and Doctoral Dissertations

No abstract provided.

The Synthesis Of Amphiphilic Diblock Copolymers: An Investigation Into The Formation Of Micelles As A Function Of Hydrophobic Block Length, Kevin S. Kawchak

Master's Theses and Doctoral Dissertations

Acrylate-based amphiphilic diblock copolymers show great potential for anti-cancer drug transport due to their ability to aggregate into protective core-shell micelles. Using RAFT polymerization, copolymers containing poly(acrylic acid) and poly(methyl acrylate) blocks were made with high monomer conversion and narrow distributions of molecular weight for eventual use in medicinal applications. Based on previous findings of copolymers with low weight hydrophobic blocks failing to micellize, it was hypothesized that increasing the poly(methyl acrylate) block length would allow for micelle formation. 1H-NMR experiments conducted in the presence of an aqueous solution yielded diminished and broadened resonances of the lengthened hydrophobic block, which …

Synthesis And Purification Of Potential Antimicrobial Peptides, Christopher Ryan Snyder

Master's Theses and Doctoral Dissertations

No abstract provided.