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Study Of Protein-Protein Interaction By Using In-Cell Nmr In Human Cells, Asma Salem M Aldousary
Study Of Protein-Protein Interaction By Using In-Cell Nmr In Human Cells, Asma Salem M Aldousary
Legacy Theses & Dissertations (2009 - 2024)
We developed a new technology to study protein-protein interaction in mammalian cells. This technology is based high resolution of Nucleic Magnetic Resonance (NMR) spectroscopy. Using this technology we studied interaction between the receptor for advanced glycation endproducts (RAGE). RAGE- is a multiligand receptor of immunoglobulin receptor family that is activated by a multitude of ligands. Activation of RAGE results in signal transduction that leads to the inflammatory response implicated in the complications of Diabetes. RAGE is an emergent drug target that has been explored for the variety of pathologist including cancers, neurological disorders, inflammatory disease, and diabetes. and Intracellular effector …
Degradation And Exciton Energy Transfer Studies In Single-Walled Carbon Nanotube Bundles, Abhishek Gottipati
Degradation And Exciton Energy Transfer Studies In Single-Walled Carbon Nanotube Bundles, Abhishek Gottipati
Legacy Theses & Dissertations (2009 - 2024)
Single walled carbon nanotubes (SWNTs) due to their unique optical behavior, large surface area, robust mechanical strength and electrical properties make them one of the ideal candidates for sensing and opto-electronic applications. In this work, we explore the energy transfer (exciton energy transfer-EET) phenomena occurring between nanotubes in bundles, using resonance Raman spectroscopy.
Application Of Encoded Microparticles Fabricated By Standard Lithography On Multiplexed Bioassay, Muhan He
Application Of Encoded Microparticles Fabricated By Standard Lithography On Multiplexed Bioassay, Muhan He
Legacy Theses & Dissertations (2009 - 2024)
Suspension microarray, has become a popular candidate for multiplexed bioassay since its advent. Unlike traditional planar microarray, suspension microarray permits the probes suspended in aqueous solution while keeping their addresses, and possesses many advantages such as large available binding surface, rapid reaction rate, high multiplexing ability, and high sensitivity and specificity. Photolithography, the technology widely utilized for production of abundant microparticles as carrier in suspension microarray, was investigated by many researchers. However, there was still not a mature, efficient method to produce microparticles with low background, easily recognized identity and good hybridization capacity. To address those issues, we developed a …
Development Of Direct Analysis In Real Time-High Resolution Mass Spectrometry (Dart-Hrms) And Statistical Analysis Tools For The Identification And Classification Of Psychoactive Plant Drugs, Ashton Danielle Lesiak
Development Of Direct Analysis In Real Time-High Resolution Mass Spectrometry (Dart-Hrms) And Statistical Analysis Tools For The Identification And Classification Of Psychoactive Plant Drugs, Ashton Danielle Lesiak
Legacy Theses & Dissertations (2009 - 2024)
In current forensic testing, a new pattern is emerging where the drugs that are submitted to crime labs for analysis are no longer restricted to well-characterized substances such as cocaine, heroin and tetrahydrocannabinol (THC). The appearance of new psychoactive substances (NPS) in forensic laboratories, including synthetic alternatives to scheduled substances and plant-based psychotropics, has highlighted issues that traditional analytical methods such as gas chromatography- and liquid chromatography-mass spectrometry impose in the characterization of these samples. These can include lengthy extractions, derivatization steps, pH adjustments and/or a host of other procedures. Since the creation of legislation to address the use of …
The Use Of Ion Mobility Spectrometry-Mass Spectrometry For The Structural Elucidation Of Progressively Larger Nucleic Acids, Jennifer Lynn Lippens
The Use Of Ion Mobility Spectrometry-Mass Spectrometry For The Structural Elucidation Of Progressively Larger Nucleic Acids, Jennifer Lynn Lippens
Legacy Theses & Dissertations (2009 - 2024)
The biomedical community and pharmaceutical industry have come to rely in ever
Fine Particulate Air Pollution In Saudi Arabia : Implications For Cardiopulmonary Morbidity, Shedrack Rujooga Nayebare
Fine Particulate Air Pollution In Saudi Arabia : Implications For Cardiopulmonary Morbidity, Shedrack Rujooga Nayebare
Legacy Theses & Dissertations (2009 - 2024)
Fine particulate (PM2.5) air pollution is a major issue in Saudi Arabia. Though the health effects of exposure to PM2.5 have been extensively studied in developed countries of Europe and North America, this research is yet to be done in developing countries of Africa, some parts of Asia and the Middle East including Saudi Arabia. This is the first comprehensive assessment of PM2.5 air pollution in Saudi Arabia describing the major emission sources as well as assessing the association of daily exposures to PM2.5 and its chemical constituents with cardiopulmonary morbidity.
An Investigation Of The Uptake, Distribution, And Accumulation Of Lead And Other Trace Elements In Caprine Brain Tissues Using Analytical Atomic Spectrometry, Amy Joanna Steuerwald
An Investigation Of The Uptake, Distribution, And Accumulation Of Lead And Other Trace Elements In Caprine Brain Tissues Using Analytical Atomic Spectrometry, Amy Joanna Steuerwald
Legacy Theses & Dissertations (2009 - 2024)
Exposure to toxic elements and dysregulation of essential elements have been implicated in neurodegenerative disorders. Despite the importance of trace elements in neurological function, little is known regarding their uptake and distribution within brain tissues. Even less is known regarding the impact of toxic metal exposure (i.e., Pb) on endogenous metals within the brain.
Synthetic Study Toward Lycopodium Alkaloids Via A Common Bicyclic Intermediate, Michaela Cara Vertorano
Synthetic Study Toward Lycopodium Alkaloids Via A Common Bicyclic Intermediate, Michaela Cara Vertorano
Legacy Theses & Dissertations (2009 - 2024)
The lycopodium alkaloids are a family of over 270 naturally occurring compounds, many of which are bioactive. Therefore, developing an efficient manner by which these alkaloids can be synthesized could be incredibly useful in studying their potential medicinal benefits. Herein, steps toward this goal were accomplished. A bicyclic ring structure was synthesized in few steps from commercially available starting materials. This structure can be viewed as a key intermediate from which several lycopodium alkaloids could be synthesized in relatively few steps. The ring system was subject to an aza-Prins cyclization reaction to synthesize the alkaloids lycopodine. Unfortunately the current synthetic …
Mutational Studies Of The Receptor For Advanced Glycation End Products (Rage) Inhibition, Sarah Corte
Mutational Studies Of The Receptor For Advanced Glycation End Products (Rage) Inhibition, Sarah Corte
Legacy Theses & Dissertations (2009 - 2024)
Abstract
The Chemistry Of New Garlic-Derived Organosulfur Compounds And The Molecular Basis Of Olfaction, Berenice Dethier
The Chemistry Of New Garlic-Derived Organosulfur Compounds And The Molecular Basis Of Olfaction, Berenice Dethier
Legacy Theses & Dissertations (2009 - 2024)
Garlic is a very popular condiment that has been used around the world for centuries. It is also a source of a remarkably extensive range of organosulfur compounds, whose chemistry is the focus of this thesis. The central reaction in formation of these compounds is the enzymatic cleavage of alk(en)yl cysteine sulfoxides by alliinases, which leads to sulfenic acids. The latter can then undergo condensation and rearrangement into various organosulfur compounds. Three aspects of the chemistry of garlic have been investigated in this thesis.