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Articles 1 - 15 of 15
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Initiated Chemical Vapor Deposition (Icvd) Polymer Thin Films : Structure-Property Effects On Thermal Degradation And Adhesion, Vijay Jain Bharamaiah Jeevendrakumar
Initiated Chemical Vapor Deposition (Icvd) Polymer Thin Films : Structure-Property Effects On Thermal Degradation And Adhesion, Vijay Jain Bharamaiah Jeevendrakumar
Legacy Theses & Dissertations (2009 - 2024)
Opportunities and challenges for chemical vapor deposition (CVD) of polymer thin films stems from their applications in electronics, sensors, and adhesives with demands for control over film composition, conformity and stability. Initiated chemical vapor deposition (iCVD) is a subset of the CVD technique that conjoins bulk free-radical polymerization chemistry with gas-phase processing. The novelty of iCVD technique stems from the use of an initiator that can be activated at low energies (150 – 300 °C) to react with surface adsorbed monomer to form a polymer film. This reduces risk for potential unwarranted side-reactions.
Luminescence Of Lanthanide Ions In Octahedral Coordinations With Comparison To The Centroid Shift And Host Lattice Exciton Energy, Sam J. Camardello
Luminescence Of Lanthanide Ions In Octahedral Coordinations With Comparison To The Centroid Shift And Host Lattice Exciton Energy, Sam J. Camardello
Legacy Theses & Dissertations (2009 - 2024)
In this dissertation, we have studied the luminescence of the lanthanide ions (Ce3+, Eu2+, Eu3+, Tb3+, and Pr3+), specifically in the highly symmetric octahedral coordination. This high symmetry coordination readily permits the optical properties of the luminescent ions to be determined spectroscopically. Relevant optical parameters such as the Stokes Shift (∆S), red shift (D(2+, 3+, A), crystal field splitting (Ɛcfs), and centroid sift (Ɛc), along with the excitation and emission spectra, are presented. Three different crystal structures were studied, namely, M2+Al2B2O7 (M2+ = Ca, Sr, Ba) doped with Eu2+ and Ce3+, KBaLn3+(BO3)2 (M3+ = all lanthanides, Y, Sc) doped with …
Two-Dimensional Chalcogenides : Material Synthesis And Nano-Device Applications, Robin Bay Jacobs-Gedrim
Two-Dimensional Chalcogenides : Material Synthesis And Nano-Device Applications, Robin Bay Jacobs-Gedrim
Legacy Theses & Dissertations (2009 - 2024)
Low-dimensional nanostructures exhibit distinct properties from their bulk counterparts. Here the synthesis of novel low-dimensional nanostructures is demonstrated using both top down and bottom up processes and their properties are investigated. Two-dimensional (2D) binary sesquichalcogenides are introduced as a viable material platform for phase change random access memory, photodetection, and the investigation of topological insulator surface states. An exponential relationship is observed between layer thickness and energy consumption during switching of 2D phase change devices, ultra-high responsivity in 2D photoresistors, and surface-rich conduction in 2D topological insulator nanoplates. Additionally, methods for the assessment of chemical purity, stoichiometry, and dimensions of …
Mixed Ligand Approach To Design Heterometallic Single-Source Precursors For Low-Temperature Preparation Of Oxide Materials, Craig Matthew Lieberman
Mixed Ligand Approach To Design Heterometallic Single-Source Precursors For Low-Temperature Preparation Of Oxide Materials, Craig Matthew Lieberman
Legacy Theses & Dissertations (2009 - 2024)
There is a considerable interest in the use of metal oxides for development of novel high-technological materials such as gas sensors, multiferroics, and electrocatalysts. In particular, the design of complex oxides, which incorporate more than one type of metal atom, is focused on enriching chemical and physical properties of the target materials and allowing for increased functionality. In order to replace the harsh conditions associated with traditional synthetic routes that often require high temperatures and/or pressures, new soft chemistry methods for the preparation of mixed-metal oxide materials have been developed. One of the most promising directions is the emergence of …
Novel Nmr Based Technologies To Study Macromolecular Structures, Subhabrata Majumder
Novel Nmr Based Technologies To Study Macromolecular Structures, Subhabrata Majumder
Legacy Theses & Dissertations (2009 - 2024)
Nuclear Magnetic Resonance Spectroscopy (NMR) is one of the principle tools in structural biology to probe macromolecular structures and interactions. The atomic resolution afforded by this technique has been widely used to probe protein-protein, and protein-ligand interactions in-vitro. However, the natural milieu of the proteins is the living cell and the cellular cytoplasm is extremely heterogeneous. The NMR studies of folded protein in-cell, till now, have been limited by non-specific interactions of the cytosol. This thesis outlays a general methodology to study protein structure/interactions inside the living cells using NMR. In a closely related objective, it also describes the use …
Distributions And Formations Of Hono In The Troposphere, Dennis Pu
Distributions And Formations Of Hono In The Troposphere, Dennis Pu
Legacy Theses & Dissertations (2009 - 2024)
Nitrous acid (HONO) is an important reactive nitrogen species and a precursor to the hydroxyl radical. It plays important roles in reactive nitrogen recycling and in photo-oxidant formation in the troposphere. However, much is still unknown about its formation mechanisms and distributions in the troposphere. This research is part of NOMADSS (Nitrogen, Oxidants, Mercury, and Aerosol Distributions, Sources and Sinks) field study contributed by over 10 research groups in the United States to investigate the tropospheric chemistry of reactive nitrogen, mercury, oxidant and aerosols. One of the goals was to study the HONO distribution and formation mechanisms in the troposphere. …
Characterization Of Metallic And Semimetallic Oxide Nanoparticles In Industrial Wastewater And Associated Toxicity, Gary Roth
Legacy Theses & Dissertations (2009 - 2024)
Engineered nanomaterials (ENMs) play an increasing role in manufacturing and consumer products. Currently, there is no standard approach to studying ENM toxicity, and a growing body of literature suggests that ENMs may have toxicity differing from similar compounds in bulk or dissolved form. I examined ENMs used in the semiconductor manufacturing process called chemical-mechanical planarization (CMP) for their properties, removal in the wastewater treatment system (WWT), in-vitro toxicity, and location post-inhalation in-vivo. It was found that ENMs in CMP slurries have morphology determined by their elemental composition, but assessment of size and concentration can differ substantially between accepted techniques. Particles …
Mass Spectrometry-Based Rnomics : Global Surveys Of Ribonucleotide Modifications As Possible Indicators Of Cell Identity, Epigenetic, Metabolic And Pathological State, Rebecca Erin Rose
Mass Spectrometry-Based Rnomics : Global Surveys Of Ribonucleotide Modifications As Possible Indicators Of Cell Identity, Epigenetic, Metabolic And Pathological State, Rebecca Erin Rose
Legacy Theses & Dissertations (2009 - 2024)
Discovery of the regulatory roles of non-protein coding RNAs (ncRNAs), once considered “junk” or “transcriptional noise”, has prompted a reassessment of the significance of the multifaceted activities of RNA in cellular response, which can result in cell transformation and diseased states. This reassessment, however, can only be accomplished if techniques are developed to capture, characterize and quantify the more than 100 covalent post-transcriptional modifications (PTMs) that adorn natural RNAs. Undoubtedly, the creation of high-throughput platforms such as next-generation sequencing and RNA-seq have provided unparalleled accuracy and sensitivity, however, they rely on strand amplification procedures that are blind to the known …
Advanced Raman Spectroscopic Methods For Structural Characterization Of Amyloid Fibrils And Bionanotubes, Valentin Sereda
Advanced Raman Spectroscopic Methods For Structural Characterization Of Amyloid Fibrils And Bionanotubes, Valentin Sereda
Legacy Theses & Dissertations (2009 - 2024)
Amyloid aggregation is a specific form of protein misfolding and self-assembly related to several degenerative pathologies like Alzheimer's and Parkinson's diseases, type-II diabetes, etc. This association with deadly diseases has made amyloid fibrils the focus of intensive research for many decades. Most recently, a significant interest to protein fibrils was also due to the application of the remarkable self-assembling capabilities to form well-structured nano-biomaterials. Self-assembly of short peptide sequences into well-organized structures is another important strategy for bottom-up fabrications of nano-biomaterials. One of the most commonly used building blocks is diphenylalanine, a short dipeptide that has been identified as playing …
Molecular Dynamics Simulations Of Small Systems To Improve Base Pairing Parameters Of The Amber-99 Force Field, Angelo Christopher Setaro
Molecular Dynamics Simulations Of Small Systems To Improve Base Pairing Parameters Of The Amber-99 Force Field, Angelo Christopher Setaro
Legacy Theses & Dissertations (2009 - 2024)
Simulations of biochemical systems are being increasingly used to further our understanding of those systems. In broad strokes, chemical simulations can be broken into two categories, those that are rooted in a quantum mechanical approach and those that are classically rooted. Molecular dynamics is one such classical method, which propagates motion of a chemical system via repeatedly solving Newton’s Laws of motion. This approach is less computationally intensive than the quantum mechanical methods and allows for the simulation of systems of tens of thousands of atoms, if not more.
Preparation, Chemistry, And Characterization Of Hypervalent Organosulfur Fluorides, Paul R. Savoie
Preparation, Chemistry, And Characterization Of Hypervalent Organosulfur Fluorides, Paul R. Savoie
Legacy Theses & Dissertations (2009 - 2024)
Since the discovery of the pentafluorosulfanyl (SF5) group around the 1960s, progress in exploring the chemistry of aliphatic SF5-containing compounds stagnated because of a lack of efficient synthetic methods. More recent developments in the preparations of SF5-containing compounds afforded easier access to these compounds, and sparked great interest in exploring their chemistry. Chapter 1 discusses the development of efficient methods used to prepare SF5-containing aliphatic compounds.
Fluorinated Hypervalent Sulfur Compounds In Synthesis, Cortney Von Hahmann
Fluorinated Hypervalent Sulfur Compounds In Synthesis, Cortney Von Hahmann
Legacy Theses & Dissertations (2009 - 2024)
The polar and steric effects of pentafluorosulfanyl (SF5) substitution on selectivity and reactivity were investigated in the ketene imine [2+2] cycloaddition reaction. The kinetic resolution of racemic aldimines rely on the stereocontrol of cyclization by dipolar substituent effects. Functionalized SF5-bearing β-lactams are used in the preparation of conformationally constrained SF5-containing β-amino acids and peptides, in the study of novel antibacterial agents and in the design of new β-lactamase inhibitors.
Single-Source Precursors For The Low-Temperature Preparation Of Rechargeable Battery Electrode Materials, Zheng Wei
Legacy Theses & Dissertations (2009 - 2024)
Lithium ion batteries have revolutionized the portable electronics market and are being intensively pursued now for transportation and for stationary storage of renewable energies. As one of the most promising alternatives, sodium ion batteries are also being actively studied owing to the high abundance and low cost of sodium sources. Electrodes play a critical role in defining the overall performance of secondary batteries, while the morphologies of electrode materials greatly determine their properties. Different synthetic methods afford electrode materials with specific morphology. Compared to traditional electrode preparation techniques, the single-source precursor approach can produce materials at significantly lower temperatures, with …
An Investigation Of Alkaline Earth And Rare Earth Elements In Human Bone Following Long-Term Parenteral Nutrition, Aubrey L. Galusha
An Investigation Of Alkaline Earth And Rare Earth Elements In Human Bone Following Long-Term Parenteral Nutrition, Aubrey L. Galusha
Legacy Theses & Dissertations (2009 - 2024)
This investigation focused on a unique collection of archived human bones obtained post-mortem from 7 patients, who had received long-term parenteral nutrition (PN) for up to 21 years. Parenterals are administered intravenously as a nutritional supplement, and may be contaminated with metals, which are completely absorbed into the blood compartment. Some metal contaminants may be deposited in the body’s reservoir for inorganic elements – bone.
Structure And Stability Of Amyloid Fibrils Studied By Advanced Vibrational Spectroscopy, Marudachalam Shanmugasundaram
Structure And Stability Of Amyloid Fibrils Studied By Advanced Vibrational Spectroscopy, Marudachalam Shanmugasundaram
Legacy Theses & Dissertations (2009 - 2024)
Protein misfolding often leads to the formation of refractory protein aggregates like amyloid fibrils. These fibrils possess a highly ordered structure and are implicated in over 25 severe diseases including Alzheimer’s, Parkinson’s and prion diseases. This work was focused on understanding the morphology and conformation of amyloid fibrils and their stability after formation. The deconstruction of fibrils as well as other aggregates like inclusion bodies under mild conditions was also investigated using Archaeal chaperones.