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Α-Arylation Of Cyclopentanone : Palladium-Catalyzed Coupling Of Enamines And Aryliodides & N-Acyloxazines As Novel Bicyclic Weinreb Amides, Kristina M. Gehring

Honors Theses

The introduction of an aryl group a to a carbonyl is a useful step in the preparation of a variety of biologically interesting compounds. The palladium-catalyzed a-arylation of ketones and esters, through their enolates, has received a great deal of attention lately. Despite these efforts, cyclopentanones remain one of the most difficult classes ofketones to arylate. Many of these methods suffer from the limitation of the relatively basic reaction conditions needed in order to prepare the enolate nucleopbiles in­situ. The direct palladium-catalyzed α-arylation of enamines as an alternative route to α­aryl ketones bas received very little attention and might be …

Synthesis And Characterization Of Novel 1-Substituted Meta-Terphenyls For Platinum Complexes, Sarah Marie Sparks

Honors Theses

The unique luminescent properties of aryl, tridentate platinum complexes has led to an increased interest and investigation of various binding modes, with an emphasis on ligand design. These complexes are anticipaterl to be useful in chemical sensing, organic light emitting diodes, and solar energy converters.

Efficient Synthesis Of N9-Alkylguanines : & Evaluation Of A More Highly Conjugated Analog Of Guanidinium-Rich Molecular Transporters Using A Ph Dependent Fluorescence Assay, David E. Olson

Honors Theses

Synthesis of N9-(2-chloroethyl)guanine from 2-amino-6-chloropurine was accomplished in three steps with an overall yield of 83%. All products were purified via crystalli7.ation and no chromatography was required. Selective crystallization of the desired N9 isomer subsequent to the key alkylation step completely and efficiently removed the N7 isomer. This compound was shown to be a versatile reagent in the synthesis of various N9-substituted guanines.

The Synthesis And Characterization Of A Metal Complex Containing Chemically Non-Equivalent Axial Cyanide Ligands, Derek D. Wayman

Honors Theses

In order to analyze the magnitude and factors which effect 13C-13C NMR coupling through a metal center, we have synthesized an octahedral dicyano cobalt (III) complex in which two trans cyanides are chemically non-equivalent. Although similar complexes have been reported, their spectroscopic characterization with isotopically labeled cyanide (13CN) has yet to be studied in detail.

The Synthesis And Characterization Of A Metal Complex Containing Chemically Non-Equivalent Axial Cyanide Ligands, Derek D. Waymand

Honors Theses

In order to analyze the magnitude and factors which effect 13C-13C NMR coupling through a metal center, we have synthesized an octahedral dicyano cobalt (III) complex in which two trans cyanides are chemically non-equivalent. Although similar complexes have been reported, their spectroscopic characterization with isotopically labeled cyanide ( 13CN) has yet to be studied in detail.

Characterization Of The Wheat Grain Pkaba1-Interacting Protein Tawd40, Natalie Wayne

Honors Theses

Abscisic acid (ABA)-mediated gene expression is a critical component of plant responses to this important hormone, which affects plant growth, development, and responses to environmental stresses. Plant responses to ABA are mediated by a number of factors including PKABA 1> an ABA-induced protein kinase involved in ABA-suppressed gene expression in cereal grains, and TaWD40, which has previously been shown to physically interact with PKABA1. A full-length 1.9 kb TaWD40 cDNA, CK210682, was sequenced as part of this project. Based on the deduced protein sequence, it is thought that TaWD40 may belong to the family of E3 ubiquitin ligases, possibly targeting …

Investigating The Mechanisms Of A Novel Ribosomal Rna Degradation System, Daniel Fowler

Honors Theses

Nonfunctional ribosomal RNA decay (NRD) is a novel quality control system that eliminates defective ribosomal RNAs (rRNAs) from yeast cells. Plasmid-encoded rRNAs containing single nucleotide substitutions in the peptidyl transferase center of 25S rRNA or the decoding center of 18S rRNA are co-expressed with endogenous rRNAs in Saccharomyces cerevisiae. Quantitative northern blots reveal the steady-state levels of the resulting nonfunctional rRNAs are markedly decreased compared to wild-type rRNAs . Furthermore, the decreased expression is not the result ofdefects in rRNA transcription or processing, but instead is due to decreased stability ofthe mature, nonfunctional rRNAs. Mutations in other functionally important rRNA …

Synthesis Of 2-Oxo-16-(3', 4'-Methylenedioxyphenyl)-Trans-15-Hexadecene, Adelajda Zorba

Honors Theses

This work presents the progress made towards synthesizing 2-oxo-16-(3', 4'methylenedioxyphenyl)-trans-15-hexadecene, an antimycobacterial compound that was originally isolated from the leaves of Piper Sanctum. The hydrocarbon chain of the molecule was synthesized first by opening a 15-pentadecanolactone ring by means of HI, and performing an E2 elimination reaction on the molecule followed by an organolithium reaction with CH3Li. Hexadec-15-en-2-one that was afforded this way was later reacted with 5-bromobenzo[d][1,3]dioxole following the appropriate Heck reaction protocol that allows for the formation of a palladium catalyzed carbon-carbon bond.

The modes of action of 2-oxo-16-(3', 4'-methylenedioxyphenyl)-trans-15hexadecene are comparable to the ones of rifampicin, a …