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The Development Of Cyclic Rgd Peptides Stabilized Through 99mtc/Re(Co)3+, Aagam Patel
The Development Of Cyclic Rgd Peptides Stabilized Through 99mtc/Re(Co)3+, Aagam Patel
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Protein secondary structure can be mimicked by incorporating structural constraints into peptides and this can be facilitated by metal coordination. The objective of this project is to establish a chelation system with a cancer targeting peptide sequence, where the coordination to a metal centre results in a cyclic metallopeptide. Cyclic RGD peptides are antagonists for αvβ3 and other integrins, which are present during tumour angiogenesis. Arg-Gly-Asp (RGD) sequence is employed in the peptide backbone, with an un-natural amino acid (3-Pal) and a chelating molecule (pyridyl-triazole, pyta) present on opposite ends of the peptide sequence to form a …