Open Access. Powered by Scholars. Published by Universities.®
Dissertations, Theses, and Capstone Projects
Bifunctional Chelator; DFO; HOPO; Ligands; Positron Emission Tomography; Zirconium-89
Articles 1 - 1 of 1
Full-Text Articles in Entire DC Network
Zirconium-89: Radiochemistry And Ligand Development Toward Improved Pet Applications, Melissa Ann Deri
Zirconium-89: Radiochemistry And Ligand Development Toward Improved Pet Applications, Melissa Ann Deri
Dissertations, Theses, and Capstone Projects
Antibodies are attractive targeting vectors for positron emission tomography (PET) based imaging agents due to their high affinity and selectivity to a variety of biological targets. Creating such imaging agents requires a radionuclide with suitable decay characteristics. This role has been filled by zirconium-89 which has a 78.41 h half-life that ideally matches the multi-day biological half-life of IgG antibodies.
However, the use of a radiometal necessitates the use of a bifunctional chelator to bind the metal and conjugate to the antibody. For 89Zr this has been the purview of various derivatives of desferrioxamine B (DFO); however, the observed …