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Enantiospecific Stereospecific Strategy For The Total Synthesis Of Sarpagine And Macroline Related Oxindole Alkaloids: First Total Synthesis Of Affinisine Oxindole, Isoalstonisine, Alstofoline, Macrogentine, N(1)-Demethylalstonisine, Alstonoxine A And Second Generation Synthesis Of Alstonisine, German Oscar Fonseca Cabrera
Theses and Dissertations
The (7R)-sarpagine/macroline related oxindole alkaloids (-)-isoalstonisine (27) and (-)-macrogentine (31) together with the (7S)-sarpagine/macroline related oxindole alkaloids (-)-affinisine oxindole (24), (-)-alstonoxine A (19), (+)-alstonisine (8, second generation total synthesis), (+)-Na-demethylalstonisine (17) and (+)-alstofoline (18) were concisely synthesized during these studies.
These oxindole alkaloids were isolated from plants of the genus Alstonia which is characterized by the preponderance of sarpagine/macroline-type indole and oxindole alkaloids. Plants that belong to this genus are mainly distributed over tropical regions of Central America, Africa, and Asia where they are used locally in traditional medicine, for example, in the treatment of malaria and dysentery. The main …