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Characterization Of Dna Interstrand Cross-Linking Agents By Liquid Chromatograhy-Mass Spectrometry, Anahit Marina Campbell
Characterization Of Dna Interstrand Cross-Linking Agents By Liquid Chromatograhy-Mass Spectrometry, Anahit Marina Campbell
Theses and Dissertations
This study is to characterize novel reactive oxygen species (ROS)-activated nitrogen mustard analogues and UV-activated alkylating agents by Liquid Chromatography-Mass Spectrometry (LC-MS). First, we optimized the instrument conditions to successfully ionize a few novel binapthalene analogues and methoxybenzene analogues by MS. The highest signal intensity for compounds 3-10 was observed when atmospheric pressure chemical ionization (APCI) with an optimized corona needle position of 5mm or 10 mm was used, which led to successful analysis of compounds 3-10 by MS. Second, we determined pharmacokinetic properties of a drug compound (FAN-NM-CH3), including animal study, assay development, optimization of MS/MS instrumental parameter and …