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Identification Of Phosphatases Involved In E2f-Associated Apoptosis, Liza D. Morales Smith
Identification Of Phosphatases Involved In E2f-Associated Apoptosis, Liza D. Morales Smith
Theses and Dissertations - UTB/UTPA
Retinoblastoma (Rb) is a tumor suppressor protein that controls a critical checkpoint between the G1 phase and the S phase of the cell cycle. Rb is able to suppress cell proliferation by binding to the E2F family of transcription factors, inhibiting its ability to activate transcription of genes necessary for cell cycle progression. Mutations in proteins involved with the Rb/E2F pathway can result in hyper-proliferative cells that overtime can acquire and accumulate additional mutations, which could lead to tumorigenesis. To prevent hyper-proliferation, aberrant cells can be eliminated through apoptosis. E2F can induce apoptosis through two pathways: through transactivation of the …
Genotyping Of Tgif Polymorphisms Associated With Schizophrenia And Psychosis, George Vera Jr.
Genotyping Of Tgif Polymorphisms Associated With Schizophrenia And Psychosis, George Vera Jr.
Theses and Dissertations - UTB/UTPA
Polymorphisms in Transforming Growth β-Induced Factor (TGIF) have been found to contribute to the risk of development of psychosis and related disorders. Identifying the genes responsible for causing schizophrenia and psychosis will allow for treatment at an earlier stage of development, saving the patient problems, time, and money. The purpose of this experiment is to determine the haplotype of DNA samples obtained from earlier experiments. The DNA samples were collected from people with schizophrenia in Costa Rica, Southern Texas, and Northern Mexico. The samples were tested using 5 single nucleotide polymorphisms (SNPs) and amplified using polymerase chain reaction (PCR). Haplotypes …