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Scaling And The Smoluchowski Equations, Jerry Goodisman, J. Chaiken
Scaling And The Smoluchowski Equations, Jerry Goodisman, J. Chaiken
Chemistry - All Scholarship
The Smoluchowski equations, which describe coalescence growth, take into account combination reactions between a j-mer and a k-mer to form a (j+k)-mer, but not breakup of larger clusters to smaller ones. All combination reactions are assumed to be second order, with rate constants K jk. The K jk are said to scale if K λj,γk =λ μγ μK jk for j ≤ k. It can then be shown that, for large k, the number density or population of k-mers is given by Ak ae -bk, where A is a normalization constant (a function of a, …
Application Of Scaling And Kinetic Equations To Helium Cluster Size Distributions: Homogeneous Nucleation Of A Nearly Ideal Gas, J. Chaiken, Jerry Goodisman, Oleg Komilov, J. Peter Toennies
Application Of Scaling And Kinetic Equations To Helium Cluster Size Distributions: Homogeneous Nucleation Of A Nearly Ideal Gas, J. Chaiken, Jerry Goodisman, Oleg Komilov, J. Peter Toennies
Chemistry - All Scholarship
A previously published model of homogeneous nucleation [Villarica et al., J. Chem. Phys. 98, 4610 (1993)] based on the Smoluchowski [Phys. Z. 17, 557 (1916)] equations is used to simulate the experimentally measured size distributions of 4He clusters produced in free jet expansions. The model includes only binary collisions and does not consider evaporative effects, so that binary reactive collisions are rate limiting for formation of all cluster sizes despite the need for stabilization of nascent clusters. The model represents these data very well, accounting in some cases for nearly four orders of magnitude in variation in abundance over …
Formation Of Monofunctional Cisplatin-Dna Adducts In Carbonate Buffer, Alexandra Binter, Jerry Goodisman, James C. Dabrowiak
Formation Of Monofunctional Cisplatin-Dna Adducts In Carbonate Buffer, Alexandra Binter, Jerry Goodisman, James C. Dabrowiak
Chemistry - All Scholarship
Carbonate in its various forms is an important component in blood and the cytosol. Since, under conditions that simulate therapy, carbonate reacts with cisplatin to form carbonato complexes, one of which is taken up and/or modified by the cell [C.R. Centerwall, J. Goodisman, D.J. Kerwood, J. Am. Chem. Soc., 127 (2005) 12768–12769], cisplatin-carbonato complexes may be important in the mechanism of action of cisplatin. In this report we study the binding of cisplatin to pBR322 DNA in two different buffers, using gel electrophoresis. In 23.8 mM HEPES, N-(2-hydroxyethyl)-piperazine-N′-2-ethanesulfonic acid, 5 mM NaCl, pH 7.4 buffer, cisplatin produces …
Dactinomycin Impairs Cellular Respiration And Reduces Accompanying Atp Formation, Zhimin Tao, Syed S. Ahmad, Harvey S. Penefsky, Jerry Goodisman, Abdul Kader Souid
Dactinomycin Impairs Cellular Respiration And Reduces Accompanying Atp Formation, Zhimin Tao, Syed S. Ahmad, Harvey S. Penefsky, Jerry Goodisman, Abdul Kader Souid
Chemistry - All Scholarship
The effect of dactinomycin on cellular respiration and accompanying ATP formation was investigated in Jurkat and HL-60 cells. Cellular mitochondrial oxygen consumption (measured by a homemade phosphorescence analyzer) and ATP content (measured by the luciferin-luciferase bioluminescence system) were determined as functions of time t during continuous exposure to the drug. The rate of respiration, k, was the negative of the slope of [O2] versus t. Oxygen consumption and ATP content were diminished by cyanide, confirming that both processes involved oxidations in the mitochondrial respiratory chain. In the presence of dactinomycin, k decreased gradually with t, the decrease being more pronounced …
Constancy In Integrated Cisplatin Plasma Concentrations Among Pediatric Patients, Jerry Goodisman, Abdul-Kader Souid
Constancy In Integrated Cisplatin Plasma Concentrations Among Pediatric Patients, Jerry Goodisman, Abdul-Kader Souid
Chemistry - All Scholarship
The authors report on the variability in the integrated quantity of free (unbound) plasma cisplatin (area under curve of plasma concentration versus time, AUC). The AUC was measured in 19 patients receiving cisplatin doses proportional to body surface areas (BSA), 30mg/m2 over 1 hour. The relative standard deviation (RSD, population standard deviation divided by mean value) for the maximum free plasma cisplatin concentration (Cmax, μM) was 0.338; for the half-life (t½, minute), 0.210; and for the AUC (μM minute), 0.320. Thus, BSA-based dosing gave significant variability in the AUC. We attempted to use (weight)a(height)b, seeking values of a and b …