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Statistical Thermodynamics And Kinetics Of Dna Multiplex Hybridization Reactions, Albert S. Benight, M. T. Horne, D. J. Fish
Statistical Thermodynamics And Kinetics Of Dna Multiplex Hybridization Reactions, Albert S. Benight, M. T. Horne, D. J. Fish
Chemistry Faculty Publications and Presentations
A general analytical description of the equilibrium and reaction kinetics of DNA multiplex hybridization has been developed. In this approach, multiplex hybridization is considered to be a competitive multichannel reaction process: a system wherein many species can react both specifically and nonspecifically with one another. General equations are presented that can consider equilibrium and kinetic models of multiplex hybridization systems comprised, in principle, of any number of targets and probes. Numerical solutions to these systems for both equilibrium and kinetic behaviors are provided. Practical examples demonstrate clear differences between results obtained from more common simplex methods, in which individual hybridization …
Europium(Iii) Macrocyclic Complexes With Alcohol Pendant Groups As Chemical Exchange Saturation Transfer Agents, Mark Woods, Donald E. Woessner, Piyu Zhao, Azhar Pasha, Meng-Yin Yang, Ching-Hui Huang, Olga Vasalatiy, Janet R. Morrow, A. Dean Sherry
Europium(Iii) Macrocyclic Complexes With Alcohol Pendant Groups As Chemical Exchange Saturation Transfer Agents, Mark Woods, Donald E. Woessner, Piyu Zhao, Azhar Pasha, Meng-Yin Yang, Ching-Hui Huang, Olga Vasalatiy, Janet R. Morrow, A. Dean Sherry
Chemistry Faculty Publications and Presentations
Paramagnetic lanthanide(III) complexes that contain hyperfine-shifted exchangeable protons offer considerable advantages over diamagnetic molecules as chemical exchange saturation transfer (CEST) agents for MRI. As part of a program to investigate avenues to improve the sensitivity of such agents, the CEST characteristics of europium(III) macrocyclic complexes having appended hydroxyethyl groups were investigated. The CEST spectrum of the asymmetrical complex, EuCNPHC3+, shows five distinct peaks for each magnetically nonequivalent exchangeable proton in the molecule. The CEST spectra of this complex were fitted to NMR Bloch theory to yield exchange rates between each of six exchanging proton pools (five on the …
Comments On The Mechanism Of Aging Of Antimony Doped Tin Oxide Based Electrochromic Devices, Joo C. Chan, Nicole A. Hannah, Shankar B. Rananavare, Laura Yeager, Liviu Dinescu, Ashok Saraswat, Pradeep Iyer, James P. Coleman
Comments On The Mechanism Of Aging Of Antimony Doped Tin Oxide Based Electrochromic Devices, Joo C. Chan, Nicole A. Hannah, Shankar B. Rananavare, Laura Yeager, Liviu Dinescu, Ashok Saraswat, Pradeep Iyer, James P. Coleman
Chemistry Faculty Publications and Presentations
Electrochromic effects of antimony doped tin oxide (ATO) nanoparticles are investigated to probe device yellowing (degradation). Voltage vs contrast ratio curves exhibit hysteresis, i.e., image-sticking phenomena due to irreversible charge insertion. X-ray, impedance and optical b* studies suggest that the yellowing/charge trapping is nanoparticle size-dependent with 4 nm size particles exhibiting the least yellowing. Yellowing results in increased impedances of electrode–electrolyte interface and electrode corrosion. Plausible sources of discoloration are formation of insulating complex alkali oxide film, carrier inversion (n-to-p type) through electrochemical Li doping, redeposition of the corroded electrode material and perhaps residual concentration of charge-transfer species.