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Missouri University of Science and Technology
<p>G proteins -- Receptors -- Research<br />Cell receptors<br />Cellular signal transduction</p>
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Constitutive Activity In Orphan G Protein Coupled Receptors, Adam Lee Martin
Constitutive Activity In Orphan G Protein Coupled Receptors, Adam Lee Martin
Doctoral Dissertations
"The goal of this research was to use a distal signaling pathway analysis to evaluate the extent of agonist independent constitutive signaling among orphan class-A G protein coupled receptors (GPCRs). These receptors translate extracellular signals via conformational change into intracellular activation of different G proteins and subsequent second messenger synthesis. These small molecules regulate cellular biochemistry, eventually leading to nuclear signaling that results in changes in gene expression. Some GPCRs are capable of signaling in the absence of an activating ligand, a phenomenon called constitutive activity that is inhibited via an "inverse-agonist". The use of cAMP dependent Luciferase expression is …