Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- Chemistry (4)
- Amber 95 (1)
- Analytical Chemistry (1)
- DC model (1)
- Diels-Alder Kinetics (1)
-
- Electrochemistry (1)
- Force field (1)
- Microbial Fuel Cell (1)
- Nuclear magnetic resonance spectroscopy. (1)
- Organic Semiconductor (1)
- Organic compounds;Chirality.;Anions. (1)
- Radial distribution function (1)
- Reaction Cavity (1)
- SC model (1)
- Shewanella putrefaciens (1)
- Solvation free energy (1)
- Spectroelectrochemistry (1)
- Surface Chemistry (1)
- Tetracene (1)
Articles 1 - 30 of 46
Full-Text Articles in Entire DC Network
Design And Synthesis Of N-Succinyl-L,L-2.6-Diaminopimelic Acid Desuccinylase Inhibitors As Potential Novel Antibiotics, Thomas Dipuma
Design And Synthesis Of N-Succinyl-L,L-2.6-Diaminopimelic Acid Desuccinylase Inhibitors As Potential Novel Antibiotics, Thomas Dipuma
Master's Theses
N-Succinyl-L,L-2,6-Diaminopimelic Acid Desuccinylase (DapE) is a bacterial enzyme located in the lysine biosynthetic pathway of all Gram-negative and most Gram-positive species of bacteria including the notorious ESKAPE pathogens, or pathogenic strains of bacteria that have developed significant levels of resistance to currently available antibiotics. As a means to combat this challenge of growing antimicrobial resistance, we have identified the bacterial enzyme DapE as a conserved, novel enzymate target within these resistant bacterial strains,as DapE is responsible for the production of m-DAP and lysine which are ultimately employed in bacterial cell wall synthesis. The overall aim of this research is to …
Synthesis And Characterization Of Ruthenium Complexes And Their Potential And Photosensitizers For Photodynamic Therapy, Keit Dine
Master's Theses
Cancer is one of the leading causes of death in the world with over 10 million people dying of the disease every year. Inorganic complexes supported by platinum metal centers are often used in cancer treatment. However, these complexes lack selectivity for tumor cells. As such, other alternatives to platinum have been explored. Ruthenium (Ru) complexes are one of the most promising candidates due to their ability to be used as photosensitizing drugs in photodynamic therapy. Herein, we report the design, synthesis, and characterization of two novel ruthenium-based complexes. One compound is a Ru(II) homoleptic complex, while the other is …
Exposing The Effects Of Reaction Cavity In Solid-Phase Reaction Kinetics, Michael Carr
Exposing The Effects Of Reaction Cavity In Solid-Phase Reaction Kinetics, Michael Carr
Master's Theses
Reactivity of molecular solids is governed by topochemical considerations, where minimizedmolecular movement dictates both product identity and kinetics. This Thesis explores the central role reaction cavity plays in the topochemical principle by using the highly varied cavities formed by the different facets of a tetracene crystal. The relative rates for ten different reaction cavities were measured via energy dispersive X-ray spectroscopy for the reaction of tetracene with vapors of maleic anhydride. Variance in cavities resulted in Diels-Alder reaction rates that differed by as much as a factor of 2.6. Effects were understood via molecular dynamic simulations which modeled the approach …
Mechanistic Investigations Of The Iron(Iii)-Catalyzed Carbonyl-Olefin Metathesis Reaction, Susan Phan
Mechanistic Investigations Of The Iron(Iii)-Catalyzed Carbonyl-Olefin Metathesis Reaction, Susan Phan
Master's Theses
Iron(III)-catalyzed carbonyl-olefin ring-closing metathesis represents a new approach toward the assembly of molecules traditionally generated by olefinˆ’olefin metathesis or olefination. Herein, we report detailed synthetic, spectroscopic, kinetic, and computational studies to determine the mechanistic features imparted by iron(III), substrate, and temperature to the catalytic cycle. These data are consistent with an iron(III)-mediated asynchronous, concerted [2+2]-cycloaddition to form an intermediate oxetane as the turnover-limiting step. Fragmentation of the oxetane via Lewis acid-activation results in the formation of five- and six-membered unsaturated carbocycles.
Building And Optimizing A Spectroelectrochemical System For The Study Of Shewanella Putrefaciens, Jonathan Muscolino
Building And Optimizing A Spectroelectrochemical System For The Study Of Shewanella Putrefaciens, Jonathan Muscolino
Master's Theses
Shewanellaceae are among the most widely studied electroactive microorganisms. This study reports on Shewanella putrefaciens under anaerobic conditions during applied potential while monitored by spectroscopy. The attachment of the microbe Shewanella putrefaciens onto an indium tin oxide electrode was found to occur after 2 hr of +0.2 V applied potential. Microbial detachment occurred with a 5 mV/s scan rate cyclic voltammogram from +0.2 V to -0.5 V to +0.2 V. This was confirmed through use of a spectroelectrochemical apparatus utilizing a standard 3 electrode setup with evanescent wave spectroscopy.
Evaluation Of The Performance Of Non-Covalent Molecular Mechanical Models For Zn2+ And Mg2+ Metal Ions, Maria Magdalena Kamm
Evaluation Of The Performance Of Non-Covalent Molecular Mechanical Models For Zn2+ And Mg2+ Metal Ions, Maria Magdalena Kamm
Master's Theses
Computer simulations using molecular dynamics (MD) on classical molecular mechanical
(MM) interatomic potentials can provide valuable information and quantitative
predictions about these systems. In MD calculations binding free energies of ions to
host molecules can be studied if correct ion solvation free energies in aqueous solution
are obtained. However, no MM models exist that parametrize various Zn2+ and
transition metals consistently and consider both structural and thermodynamic data
simultaneously.
The first part of our work focused on MD free energy perturbation (FEP) simulations
to derive MM interaction parameters for Zn2+ and Mg2+ ions in aqueous
solution. To obtain these parameters …
Novel Synthetic Route To 5-Substituted Indoles, Helen Y. Chen
Novel Synthetic Route To 5-Substituted Indoles, Helen Y. Chen
Master's Theses
No abstract provided.
Molecular Dynamics Of Crosslinked And Normal Hemoglobins, Liang Zhao
Molecular Dynamics Of Crosslinked And Normal Hemoglobins, Liang Zhao
Master's Theses
No abstract provided.
Effects Of Perinatal Exposure To Cocaine On Sexually Differentiated Gonadotropin Regulation In Rats, Jihun M. Lee
Effects Of Perinatal Exposure To Cocaine On Sexually Differentiated Gonadotropin Regulation In Rats, Jihun M. Lee
Master's Theses
No abstract provided.
Molecular Dynamics Of The Hammerhead Ribozyme, Vasant T. Gandhi
Molecular Dynamics Of The Hammerhead Ribozyme, Vasant T. Gandhi
Master's Theses
No abstract provided.
Syntheses Of Monometallic And Bimetallic Pd(Ii) Catalysts Supported On Polymer Surface And Their Applications In Organic Syntheses, Qin Jian Yu
Master's Theses
No abstract provided.
The Application Of Matrix Assisted Laser Desorption Ionization Time Of-Flight Mass Spectrometry (Maldi Tof Ms) For Dna Adducts And Cross-Linked Hemoglobin Analysis, Xiaomei Gu
Master's Theses
No abstract provided.
Electrochemical Cleavage Of Phenylsulfones, Joseph E. Lohr
Electrochemical Cleavage Of Phenylsulfones, Joseph E. Lohr
Master's Theses
No abstract provided.
Electrochemical, Chromatographic, And Spectrometric Studies Of An Osmium Containing Polymer, Lawrence John Rhodes
Electrochemical, Chromatographic, And Spectrometric Studies Of An Osmium Containing Polymer, Lawrence John Rhodes
Master's Theses
No abstract provided.
Studies On The Cyclization Of Cis-1,4-Dichloro-2-Butene With Sodium Dialkylmalonates, Hovis M. E. Imade
Studies On The Cyclization Of Cis-1,4-Dichloro-2-Butene With Sodium Dialkylmalonates, Hovis M. E. Imade
Master's Theses
No abstract provided.
Electrochemical Studies Of Hemoglobin And Cross-Linked Hemoglobin, Ayoola O. Alabi
Electrochemical Studies Of Hemoglobin And Cross-Linked Hemoglobin, Ayoola O. Alabi
Master's Theses
No abstract provided.
Synthesis Of Model Tripeptides And Approaches To The Preparation Of A Transition State Analogue Of Phosphoramidon, Nadina Monberg
Synthesis Of Model Tripeptides And Approaches To The Preparation Of A Transition State Analogue Of Phosphoramidon, Nadina Monberg
Master's Theses
No abstract provided.
Molecular Modeling Studies Of Hemoglobin Crosslinking Reactions, Patricia A. Pavlik
Molecular Modeling Studies Of Hemoglobin Crosslinking Reactions, Patricia A. Pavlik
Master's Theses
No abstract provided.
Comparing Normal And Sickle Hemoglobin Oxidation And Heme Transfer In The Presence Of Phosphatidylserine Vesicles, Qinghai Pan
Comparing Normal And Sickle Hemoglobin Oxidation And Heme Transfer In The Presence Of Phosphatidylserine Vesicles, Qinghai Pan
Master's Theses
No abstract provided.
Electrochemical Studies Of Swelling And Shrinking Of Clay Films, Jia Du
Electrochemical Studies Of Swelling And Shrinking Of Clay Films, Jia Du
Master's Theses
No abstract provided.
A Clay Modified Electrode For Ion-Exchange Voltammetry, Thaddeus S. Wielgos
A Clay Modified Electrode For Ion-Exchange Voltammetry, Thaddeus S. Wielgos
Master's Theses
No abstract provided.
Nmr Study Of Na+-H+ And Na+-Li+ Exchange In Human Erythrocytes, Suilan Mo
Nmr Study Of Na+-H+ And Na+-Li+ Exchange In Human Erythrocytes, Suilan Mo
Master's Theses
No abstract provided.
Correlation Of 17o Chemical Shifts Of Chromium Carbene Complexes With Moss' Mxy Reacitvity Parameter, Shuyuan Liao
Correlation Of 17o Chemical Shifts Of Chromium Carbene Complexes With Moss' Mxy Reacitvity Parameter, Shuyuan Liao
Master's Theses
No abstract provided.
Catecholamine Secretion In Bovine Chromaffin Cells : Influence Of Immune-Derived Factors, Zhaohui Wang
Catecholamine Secretion In Bovine Chromaffin Cells : Influence Of Immune-Derived Factors, Zhaohui Wang
Master's Theses
No abstract provided.
Reactions Of 1-Triptycyl Carbinol And Bis-(1-Triptycyl)-Carbinol, Bryce Arthur Milleville
Reactions Of 1-Triptycyl Carbinol And Bis-(1-Triptycyl)-Carbinol, Bryce Arthur Milleville
Master's Theses
No abstract provided.
The Synthesis Of Chiral Building Blocks Using Beta-Hydroxy Sulfoxide Dianions, Carla M. Edwards
The Synthesis Of Chiral Building Blocks Using Beta-Hydroxy Sulfoxide Dianions, Carla M. Edwards
Master's Theses
No abstract provided.
A Study Of Some Tetraarylborate-Pvc Membrane Electrodes, Boonrod Hirunmitnakon
A Study Of Some Tetraarylborate-Pvc Membrane Electrodes, Boonrod Hirunmitnakon
Master's Theses
No abstract provided.
Spectrophotometric Determinations Of The Sulfonamides, Paul William Brna
Spectrophotometric Determinations Of The Sulfonamides, Paul William Brna
Master's Theses
No abstract provided.
The Determination Of Small Amounts Of Carbon Monoxide In Air, Edward J. Fitzsimons
The Determination Of Small Amounts Of Carbon Monoxide In Air, Edward J. Fitzsimons
Master's Theses
No abstract provided.
A Spectrophotometric Study Of The Solution Of Iodine In Aqueous Potassium Iodide, Joseph L. Schneider
A Spectrophotometric Study Of The Solution Of Iodine In Aqueous Potassium Iodide, Joseph L. Schneider
Master's Theses
No abstract provided.