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Chemical and Pharmacologic Phenomena
Loma Linda University Electronic Theses, Dissertations & Projects
- Keyword
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- Left Shift of the BK Channel; Basilar Artery Myocytes; Molecular Cloning; Heterologous Express; Patch-Clamp Electrophysiology; (1)
- Nitric Oxide Oxidation; Cardiovascular Homeostasis; Gastrointestinal Homeostasis; Enterosalivary recirculation; Bacterial Nitrate Reductases; Gastro-protective Effects; (1)
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Dietary Intake And Bio-Activation Of Nitrite And Nitrate In Newborn Infants, Jesica Ann Jones
Dietary Intake And Bio-Activation Of Nitrite And Nitrate In Newborn Infants, Jesica Ann Jones
Loma Linda University Electronic Theses, Dissertations & Projects
Nitrate and nitrite are commonly thought of as inert end products of nitric oxide (NO) oxidation, possibly carcinogenic food additives, or well-water contaminants. However, recent studies have shown that nitrate and nitrite play an important role in cardiovascular and gastrointestinal homeostasis through conversion back into NO via a physiological system involving enterosalivary recirculation, bacterial nitrate reductases, and enzyme-catalyzed or acidic reduction of nitrite to NO. The diet is a key source of nitrate in adults; however, infants ingest significantly less nitrate due to low concentrations in breast milk. In the mouth, bacteria convert nitrate to nitrite, which has gastro-protective effects. …
Acclimatization To High-Altitude, Long-Term Hypoxia Alters Bk Channel Structure And Function, Xiaoxiao Tao
Acclimatization To High-Altitude, Long-Term Hypoxia Alters Bk Channel Structure And Function, Xiaoxiao Tao
Loma Linda University Electronic Theses, Dissertations & Projects
We examined the major possible mechanisms for the left shift of the BK channel I-V relationship in native basilar artery myocytes from the two LTH groups. These mechanisms included: differential expression of the accessary BK -1 subunit; differential phosphorylation of the BK subunit; and splice variation of the BK subunit. Using molecular cloning, heterologous expression, and patch-clamp electrophysiology techniques, we elucidated a mechanism that, at least in part, contributes to the differences we observed between channels from native normoxic and LTH myocytes.