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Analyses Of The Mec1 Dna Damage Pathway In Saccharomyces Cerevisiae, William Barrett Ainsworth
Analyses Of The Mec1 Dna Damage Pathway In Saccharomyces Cerevisiae, William Barrett Ainsworth
LSU Doctoral Dissertations
Eukaryotic organisms implement conserved surveillance machinery to sense and respond to DNA damage. Fundamental to the repair process is coordinated regulation of repair genes and initiation of cell cycle arrest protocols. Failure to preserve these checkpoints results in accumulation of mutated DNA and aberrant cell phenotypes that are characteristic of human disease. The yeast, Saccharomyces cerevisiae, utilizes the MEC1 checkpoint pathway to regulate the DNA damage response. This study addressed two overarching themes of transcriptional and post-translational regulation within the MEC1 pathway. We first applied our understanding of the MEC1 DNA damage transcriptional response to develop advanced luciferase whole cell …