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Integrating Galectin-3 Into A Computational Model Of Cardiac Fibrosis Progression, Adam Pieratt
Integrating Galectin-3 Into A Computational Model Of Cardiac Fibrosis Progression, Adam Pieratt
Chemical Engineering Undergraduate Honors Theses
Cardiac fibrosis, a large contributor to heart failure, is the excessive accumulation of extracellular matrix in response to stress or injury. There are no approved treatments for cardiac fibrosis, and targeting specific species involved creates complex problems for drug development, so a computational model of the cardiac fibroblast signaling network can be used to observe the interactions involved in the progression of cardiac fibrosis. In this paper, a new protein called galectin-3 is integrated into this existing model, and connections are established to expand the coverage of the network. The additions are described, simulated using Netflux biological system simulation software, …
Design And Cost Analysis Of Acrylic Acid Plant, Adam Ferrier
Design And Cost Analysis Of Acrylic Acid Plant, Adam Ferrier
Chemical Engineering Undergraduate Honors Theses
The purpose of this project was to model and design a plant to produce 75,000 tons per year of acrylic acid. Using the design in section B.9 of Richard Turton’s Analysis, Synthesis, and Design of Chemical Processes as a starting point, a plant was designed based around the partial oxidation of propylene to acrylic acid. The final plant design produces about 86,000 tons per year of acrylic acid. Using an interest rate of 10%, the plant has a discounted cash flow rate of return of 32% over 2 years of startup and 10 years of operation. Attached is an executive …