Digital Commons Network^™

Computational Predictions Of Heart Failure Drug Effects On Cardiac Fibrosis, Aaron Gardner

Chemical Engineering Undergraduate Honors Theses

The extracellular matrix is a complex system surrounding cells that is crucial to all of the cardiovascular system’s functions. Fibrosis is an excessive accumulation (scarring) of the extracellular matrix. Fibrosis is typically a negative event, and the scarring must be reduced in the heart in order to maintain its functionality. Due to this, simulations are run using the software “Netflux” in order to determine the effects of different heart failure drugs on cardiac fibrosis. The drugs that were simulated were an ACE Inhibitor, BAR Beta Blocker, ARB Blocker, and Entresto. These drugs were simulated over 50 hours at three different …

Integrating Galectin-3 Into A Computational Model Of Cardiac Fibrosis Progression, Adam Pieratt

Chemical Engineering Undergraduate Honors Theses

Cardiac fibrosis, a large contributor to heart failure, is the excessive accumulation of extracellular matrix in response to stress or injury. There are no approved treatments for cardiac fibrosis, and targeting specific species involved creates complex problems for drug development, so a computational model of the cardiac fibroblast signaling network can be used to observe the interactions involved in the progression of cardiac fibrosis. In this paper, a new protein called galectin-3 is integrated into this existing model, and connections are established to expand the coverage of the network. The additions are described, simulated using Netflux biological system simulation software, …

Optimization Of Collagen And Cell Concentrations For Engineered Tissues, Avery Fiser

Chemical Engineering Undergraduate Honors Theses

Improvements regarding the drug discovery process are necessary due to less than 1% of drugs making it from the initial discovery phase to patient treatment in clinics. One method of enhancing this process involves improving the relevance and dependability of in vitro testbeds utilized during pre-clinical testing. Improvement along these factors can provide a more relevant view for eventual drug behavior in patients. This additional relevance can allow for a reduced timeline in drug development for improving patient care. A consistent and morphologically sound baseline engineered tissue is vital to the creation of successful experimental models. Parameters such as cell …

Modeling Sex-Specific Changes In Myocardial Fibrosis, Grace Martin

Chemical Engineering Undergraduate Honors Theses

Heart disease the leading cause of death for both men and women in the United States. Cardiac fibrosis, or accumulation of extracellular matrix proteins in the heart, can occur after a heart attack and increase the risk for further complications. Current treatments for heart disease do not include extracellular matrix regulators, partly due to the complicated signaling network responsible for the production of these proteins. By using a computational model of the signaling network in cardia fibroblasts, the relationship between particular molecules and downstream extracellular matrix production can be examined.

Biological sex is an important factor for cardiac health and …

Biomass Derived Lignin Polymer Modification For Sustainable Chemical Engineering Applications, Samantha Glidewell, Keisha Walters

Chemical Engineering Undergraduate Honors Theses

Lignin is an abundant naturally occurring plant-based polymer that is branched, highly unsaturated, and rich in aliphatic and aromatic hydroxyl groups. Lignin is a significant byproduct of the wood pulp and paper industries; however, it has yet to be widely utilized in commercial applications due to its non-linear structure, broad range of molecular weights, hydrophobicity, high rigidity, and brittleness. Recent investigations into modifying lignin to broaden its potential uses have shown promising results. This thesis explores different modification techniques of the naturally occurring hardwood lignin polymer for specific applications in areas of water treatment and polyurethane (PU) production. The first …

Developing Anisotropic Soft Matter As Functional Materials To Interface With Biological Systems, Homa Ghaiedi

Graduate Theses and Dissertations

Liquid crystals (LCs) constitute a subset of soft matter possessing hybrid characteristics from both liquid and crystalline phases. In this state, the center of masses remains uncorrelated similar to an isotropic phase, while the long axis of molecules aligns in parallel, resulting in molecules exhibiting orientational and positional order, either individually or concurrently. The directional alignment inherent in LCs arises from the asymmetrical shape and structure of the constituent molecules, causing a spontaneous self-assembly into ordered phases. This cooperative molecular behavior manifests distinctive optical features when subjected to cross polarizers. The remarkable sensitivity of LCs to external stimuli, including temperature, …

Yeast Surface Display Of Multiple Heterologous Proteins Via Molecular And Biochemical Processing Techniques, Shadrach Ibinola

Graduate Theses and Dissertations

The arming of yeast cell wall, also known as yeast surface display, is an effective technology for expressing target proteins extracellularly. It has been shown to provide bioengineered yeast with qualities that are not known to native yeast such as the ability to survive harsh conditions including high pH and temperature, for example. Furthermore, this technique has been implemented for various applications which include, protein engineering, bioethanol production, bioremediation, vaccine construction, and antibody development. The major mechanisms of yeast surface display exploit agglutination, flocculation, or proteins with internal repeats as the means by which a target (protein) is covalently attached …

Development Of Lignin-Based Copolymers And Polymer Blends, David Chem

Graduate Theses and Dissertations

Increasing industrial interest in reducing fossil fuels in virgin polymer production and incorporating bio-based polymeric materials has led researchers to explore the potential of utilizing plant-based polymers such as lignin. Chapter 1 of this thesis presents a comprehensive overview of copolymerization and blending techniques for lignin and synthetic polymers, emphasizing different types of modifications and copolymerization techniques as well as key parameters such as temperature, reaction time, pH level, and solution compositions. These valorization methods are directed towards the development of high-value lignin-based materials with properties well-suited for various commercial applications. Chapter 2 offers a fundamental exploration into the amination …

Treating High Salinity Produced Water Using Hybrid Membrane Processes: Electrocoagulation-Microfiltration/Ultrafiltration-Membrane Distillation-Crystallization, Mahmood Gheni Jebur

Graduate Theses and Dissertations

Produced water (PW) is considered the largest industrial wastewater stream in the world. PW generated from oil and gas operations generally contains a range of contaminants including high total dissolved solids, high total suspended solids, polar and nonpolar organic compounds, and low surface tension dissolved species. Treating PW is very challenging and applying only membrane-based technologies is not sufficient due to membrane fouling, which affects their long-term performance. Hence, integrated membrane processes are required to treat PW effectively. Hybrid membrane processes, which may result from combining a conventional process with a membrane separation, could be used to address the issues …

Wind Tunnel Modeling Of The Jack Rabbit Ii Mock Urban Environment Chlorine Releases Based On Comparison With Field Scale Video Record, Samuel Gallimore

Graduate Theses and Dissertations

Unintentional releases of hazardous gases have led to significant injuries and fatalities in severe cases. Field tests can be used to release hazardous gases to document and evaluate the behavior of the gases. Chlorine is an especially hazardous gas due to its toxicity. The Jack Rabbit II Phase I field tests released chlorine within a mock urban environment (MUE) consisting of Conex containers arranged in rows to simulate buildings and streets. The number of field tests is limited by both expense and time. Simulation of a field test using a wind tunnel model can provide additional data and opportunity for …

Investigation Of The Flow Field In The Jack Rabbit Ii Mock Urban Environment Field Tests Using A 1:50 Scale Wind Tunnel Model, Paulo Victor De Freitas Lopes

Graduate Theses and Dissertations

Accidental release of toxic chemicals can put workers and nearby populations at significant risk. Consequence assessment of accidents in urban environments is of particular interest. Urban geometries create wind channels between buildings, along with particularly dangerous areas downwind of buildings, where near-stagnant flow is present. Furthermore, recirculation zones can be formed between buildings, trapping high concentrations of toxic gases at ground level, particularly for denser-than-air gases. In 2015, the Department of Homeland Security conducted the Jack Rabbit II Field Test (JR-II) at Dugway Proving Ground, UT. During JR-II, chlorine was released at the center of a Mock Urban Environment (MUE) …

Greenhouse Gas Emissions From Milk Production In The Us, Cailey Cooper

Chemical Engineering Undergraduate Honors Theses

Life cycle assessment is performed to determine the environmental impacts of the life cycle of a product. In this study, the greenhouse gas emissions from milk production in the United States were calculated using a cradle-to-gate analysis. The dairy industry has a noticeable impact on the total greenhouse gas emissions in the US. Performing life cycle assessment provides information about the main emission sources in the life cycle which can spark innovative changes to reduce these emissions. The life cycle assessment was performed using the openLCA software and ReCiPe impact assessment methodology. The results indicated that 1.28 kg of carbon …

Separation Of Organic Acids Through Direct Catalysis From Sugars, Katelyn Robinson

Chemical Engineering Undergraduate Honors Theses

Society relies on plastic products, whether they are single use or durable. A downside of plastic is that the most common type is a product of oil and oil is not only a limited resource but also a climate-damaging resource. Polylactic acid (PLA) is a bio-based, biodegradable plastic. However, the process of converting biomass to polylactic acid polymer has the largest environmental impact of the PLA production process, so alternative methods of conversion are needed (Moretti et al., 2021). The polylactic acid polymer can be made with lactic acid, which can be converted from glucose.

A Teaching Unit Plan For Introducing Engineering In 1st-2nd Grade Classrooms, Claudia Smith

Chemical Engineering Undergraduate Honors Theses

The field of engineering, and specifically chemical engineering, is projected to increase significantly over the next 10 years. Engineering programs require students to have a strong foundation of math and science. Students in the United States are often underprepared to enter these programs, and the majority of high school students are not interested in pursuing a career in the STEM field at all. For this project, a unit teaching plan was created to introduce students to the field of engineering, providing a foundation for their upper-level STEM classes, and encouraging them to consider engineering as a career in the future. …

Comparing Firocoxib And Meloxicam In The Application Of Microneedle Patch For Transdermal Drug Delivery, Ruohan Li

Chemical Engineering Undergraduate Honors Theses

This thesis compares the performance of meloxicam and firocoxib in the aspects of its physical characteristic, chemical compositions, and in-vitro performances for transdermal pain management microneedle patches on farm animals. The microneedle patches are composed of polyvinyl alcohol (PVA), type I collagen (COL), and chitosan (CHI) as base material that carries NSAIDs to achieve therapeutic purposes. Scanning electron microscopy (SEM) was utilized to observe the morphological and physical characteristics of the microneedle patches. Both meloxicam and firocoxib microneedle patches were successfully prepared using the methodology, with organized microneedle distribution and sizing. And Fourier transform infrared spectroscopy (FTIR) confirmed the chemical …

Heat Transfer From Plates, Leanza Trevino

Chemical Engineering Undergraduate Honors Theses

The purpose of this honors thesis is to create an experiment for the CHEG Lab I course. This is a continuation of work done by Alexa Moreno. She created an experiment to model free convection of a horizontal plate. In this report, free and forced convection of a vertical and horizontal plate, respectively are modeled. This report explains the motivation for creating this heat convection experiment, the results of performing the experiment, and provides recommendations for future work on this experiment. Lab handouts are included in the Appendix.

Lignin Copolymer Property Prediction Using Machine Learning, Collin Larsen

Chemical Engineering Undergraduate Honors Theses

Lignin, an abundant biopolymer, is a waste byproduct of the paper and pulp industry. Despite its renewable nature and potential applicability in various products, such as plastics and composites, the development of lignin-based materials has been impeded by the cumbersome, Edisonian process of trial and error. This research proposes a novel approach to forecasting the properties of lignin-based copolymers by utilizing a recurrent neural network (RNN) based on the Keras models previously created by Tao et al. Example units of modified lignin were synthesized via esterification and amination functional group modifications. To increase the efficiency and accuracy of the prediction …

Battery Design, Construction, And Characterization For Small Motor Use Focusing On Anodic Zinc For Electron Flow, Amber Veach

Chemical Engineering Undergraduate Honors Theses

This thesis explores the construction, characterization, and application of anodic zinc batteries for powering a small electric motor for the ChemE Car competition. Two zinc galvanic cell batteries were studied: zinc-carbon and zinc-air batteries. Prototype batteries were constructed and tested for voltage, amperage, and power production. In the zinc-carbon trials, a 3:1 mixture of manganese dioxide and graphite was determined to be the best cathode for power production. The size which allowed for sufficient power while maintaining the smallest footprint on the car was a zinc can six cm tall and two cm in diameter. Analysis of paper zinc-air battery …

A Comparison Of Optical Measurement Methods For The Growth Of S. Cerevisiae, Jackson Black

Chemical Engineering Undergraduate Honors Theses

Genetic engineering of living organisms provides the opportunity to express and harvest different proteins from cell surfaces. Yeast (S. cerevisiae) is one such organism and is capable of being grown on an industrial scale. Cellular concentration is an important parameter to monitor while fermentation processes are underway, in order to control the environment inside the growth medium and maximize yields. Spectrophotometry is a conventional method for measuring concentration, but is limited by a narrow absorbance range, and the need for on-site periodic sampling. A continuous method of measurement, as provided by Bug Labs BE2100 non-invasive biomass monitor, would …

Estimating Toxic Load From Finite-Duration Contaminant Releases In Wind Tunnel Experiments, Patrick B. Jones

Chemical Engineering Undergraduate Honors Theses

When gaseous contaminants are released into the atmosphere said contaminants form clouds that travel in the prevailing wind direction. An individual caught in the downwind path of one such cloud will accumulate a dosage, or toxic load, of said contaminant that is dependent on a multitude of environmental factors. This thesis quantifies unpredictability – or variation – in toxic load measurements using downwind concentration data captured from finite-duration gaseous contaminant releases conducted at set conditions in the Chemical Hazards Research Center ultra-low speed wind tunnel.

Finite-duration releases can be divided into two categories – time-limited steady releases and puffs – …

Measuring Plume Concentration Variations Under Neutral Atmospheric Conditions, Daniel Williams

Chemical Engineering Undergraduate Honors Theses

Hazardous gases are increasingly becoming a large safety concern as the world continues to grow and industrialize. The modeling of when hazardous gases breach containment is an extremely important objective of consequence assessment planning and response. To improve the understanding of the variability inherent in passive gas releases, a test program to demonstrate the variability of gas concentration measurements at different location in a passive gas plume released from an area source in the ultra-low speed wind tunnel at the Chemical Hazards Research Center. A Flame Ionization Detector was used to measure the concentration of the source cloud. Methane was …

Characterizing And Quantifying Shear-Induced Hemolysis In A Hollow Fiber Membrane System, Siddhi Bhat

Chemical Engineering Undergraduate Honors Theses

Clinical studies have shown that patients undergoing renal replacement therapy are more susceptible to developing hemolysis, or the rupturing of red blood cells. Rapid hemolysis can cause symptoms such as anorexia, vomiting, and even death in severe cases. The aim of this study is to identify how shear stress within a hollow fiber membrane impacts the level of hemolysis that occurs. This allows for the optimization of the ultrafiltration membranes that are typically used for hemofiltration treatments. The variables being studied are the radii of hollow fibers, number of fibers, and volumetric flow rate of blood being circulated. Here, we …

Utilization Of Electrodeionization To Separate And Concentrate Cellobionic And Gluconic Acid, Andie Veeder

Chemical Engineering Undergraduate Honors Theses

Biofuel production is currently an expensive and inefficient process with many drawbacks. It is water and land intensive, competes with food production, and requires large energy inputs decreasing its relative sustainability. This paper explores the use of electrodeionization (EDI) to improve the biofuel process by separating and concentrating large, organic sugar acids that are important materials for the production of bioethanol. An EDI device was assembled for the purpose of separating and concentrating gluconic, cellobionic and lactobionic acid. Several trials were conducted and samples were analyzed to determine the success of this experiment. The results for the separation and concentration …

Tangential Flow Treatment Of Poultry Processing Wastewater Using Stainless Steel Ultrafiltration Membrane, Saubana Olorunsola Dada

Graduate Theses and Dissertations

The current treatment of poultry processing wastewater (PPW) requires a large expanse of land, takes time, and requires chemical usage. The wastewater is typically treated prior to discharge. Apart from aiming to reuse the treated water for non-potable activities, this project aimed to reduce the footprint and time required for PPW treatment. To intensify the PPW treatment units, we studied the possibility of replacing dissolved air floatation (DAF) with a stainless steel ultrafiltration membrane (SSUF). Combined PPW from all processing units taken before the first DAF and the second DAF were used for this study with no pretreatment. The SSUF …

Dpd Guided Insight On The Formation Process Of Polyethersulfone Membranes By Nonsolvent Induced Phase Separation And The Effects Of Additives, Eric Ledieu

Graduate Theses and Dissertations

Dissipative particle dynamics (DPD), a coarse grain simulation method, was applied to the membrane formation process of non-solvent induced phase separation (NIPS) to gain further insight on the mechanism of certain variables and how they affect the final morphology. NIPS involves two solutions, an organic polymer dissolved in an organic solvent colloquially called the dope and an aqueous coagulation bath, brought into contact with one another. The solvents then mix, causing the polymer to fall out of solution as an asymmetric membrane with a dense surface layer and a more open subsurface layer in response to the decreasing solubility. Polyethersulfone …

Polymeric Biomaterials Approaches For Engineering The In Vitro Cellular Microenvironment For Mscs, Mahsa Letter-Mahsa Haseli

Graduate Theses and Dissertations

Cell therapy is a technology that relies on replacing diseased or dysfunctional cells with healthy functioning ones. One of the cells used for such advanced therapies are stem cells, owing to their ability to differentiate into specific cells required for repairing damaged or defective tissues or cells. The majority of cell-based products are intended to transiently persist in the patient, secreting factors which then allow the patient’s body to heal; in these products, the cells are subsequently eliminated from the body. Furthermore, unique manufacturing platforms, in addition to novel commercialization strategies, will be required to create a successful, sustainable cell …

Using Copper Oxide And Zwitterions To Prevent Membrane Fouling And Optimizing Ultrafiltration Membrane Fabrication With Green Solvents, Cannon Hackett

Graduate Theses and Dissertations

Membrane fouling and sustainable production of membranes are two of the most important challenges in membrane science. Chapter 1 of this dissertation introduces these challenges and covers previous research that has been done in those areas. Additionally, the objectives of this dissertation are stated. In chapter 2, a study was done in which polyethersulfone ultrafiltration membranes were functionalized with copper oxide nanoparticles and zwitterions for the purpose of reducing fouling on the membrane surface. Characterization confirmed the attachment of each component to the membranes. Dead-end filtration was performed with water and bovine serum albumin solution and showed that the functionalization …

Enhancing Human Schwann Cells Reparative Behavior Using Heparin/Collagen Layer-By-Layer Coatings, Luis Carlos Pinzon-Herrera

Graduate Theses and Dissertations

When a peripheral nerve injury (PNI) occurs, the gold standard for tissue regeneration is the use of autografts. However, due to the secondary effects produced by multiple surgeries involved in the removal and implantation of autografts for very small lesions, it is possible to replace them with the use of Nerve Guide Conduits (NGCs). However, NGCs are limited to short lesions (less than 1 cm). This limitation is caused by the absence of compounds in the extracellular matrix (ECM) that autografts can provide. Since much of the regenerative process takes place on the NGC surface, our work aims to modify …

Study Of Thermoelectric And Lattice Dynamics Properties Of 2d Layered Mx (M = Sn, Pb; X = S, Se, Te) And Zrs2 Compounds Using First-Principles Approach, Abhiyan Pandit

Graduate Theses and Dissertations

The aim of this dissertation is the investigation of thermoelectric and lattice dynamics properties of two-dimensional (2D) MX (M = Sn, Pb; X = S, Se, Te) and ZrS2 compounds based on the first-principles density functional theory. The dimensionality reduction (e.g., using 2D structure) of bulk materials is found to have enhanced thermoelectric efficiency. This enhancement is attributed to the increase of the Seebeck coefficient as a result of higher electronic density of states near the Fermi level in low-dimensional materials. In addition, lowering the dimensionality increases phonon scattering near interfaces and surfaces in 2D materials, which leads to a …

Wind Tunnel Modeling Of Jack Rabbit Ii Mock Urban Environment Gas Concentration Measurements, Sami S. Fares

Graduate Theses and Dissertations

The 2015 Jack Rabbit (JR) II field trials were conducted to improve understanding of the denser-than-air dispersion of chlorine in an urban environment. The field study involved five large-scale, outdoor release trials of chlorine in a mock urban environment (MUE) at Dugway Proving Ground (DPG). Various instrumentation was deployed, including JazTM Ultraviolet-Visible (UV-Vis) point sensors capable of measuring gas-phase chlorine concentration throughout the mock urban array.

The Chemical Hazards Research Center (CHRC) was tasked by the Chemical Security Analysis Center (CSAC) with the Mock Urban Wind Tunnel (MUWT) program to study the 2015 JR II Trials at wind tunnel scale. …