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Experimental And Modeling Studies In Membrane Distillation, Lin Li
Experimental And Modeling Studies In Membrane Distillation, Lin Li
Dissertations
A variety of microporous hydrophobic flat sheet membranes of polyvinylidene fluoride (PVDF) and expanded-polytetrafluoroethylene (e-PTFE) are studied to evaluate the influence of membrane properties on their performance in desalination by direct contact membrane distillation (DCMD) and vacuum membrane distillation (VMD) processes. The membrane thickness is varied between 23 μm to 125 μm; the pore size is varied from 0.05 μm to 0.45 μm. The porosity is generally high in the range of 0.7 - 0.8. DCMD experiments are performed over a hot brine temperature range of 65 °C to 85 °C and distillate temperature at 25 °C for various brine …
Discrete Element Method Based Scale-Up Model For Material Synthesis Using Ball Milling, Priya Radhi Santhanam
Discrete Element Method Based Scale-Up Model For Material Synthesis Using Ball Milling, Priya Radhi Santhanam
Dissertations
Mechanical milling is a widely used technique for powder processing in various areas. In this work, a scale-up model for describing this ball milling process is developed. The thesis is a combination of experimental and modeling efforts.
Initially, Discrete Element Model (DEM) is used to describe energy transfer from milling tools to the milled powder for shaker, planetary, and attritor mills. The rolling and static friction coefficients are determined experimentally. Computations predict a quasi- steady rate of energy dissipation, Ed, for each experimental configuration. It is proposed that the milling dose defined as a product of Ed and milling …
Design Of Novel Drug Delivery System And Optimal Dosage Regimens, Kwang Seok Kim
Design Of Novel Drug Delivery System And Optimal Dosage Regimens, Kwang Seok Kim
Dissertations
Three representative drug delivery systems were analyzed to emphasize the roles of mathematical models and computer-aided simulations in pharmaceutical research. In the first project, a protocol was developed so that the optimal regimen, consisting of the intravenous boluses and subsequent infusion of theophylline, could be obtained once information on the pharmacokinetics became available. The method was based on a two-compartment model of the human body. A module was created and posted on a website for free access. The second project dealt with the transdermal heat-assisted delivery of corticosterone. Heat conduction and drug diffusion through the patch and the skin were …