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Predicting Biomaterial Property-Dendritic Cell Phenotype Relationships From The Multivariate Analysis Of Responses To Polymethacrylates, Abraham Joy
Abraham Joy
Dendritic cells (DCs) play a critical role in orchestrating the host responses to a wide variety of foreign antigens and are essential in maintaining immune tolerance. Distinct biomaterials have been shown to differentially affect the phenotype of DCs, which suggested that biomaterials may be used to modulate immune response towards the biologic component in combination products. The elucidation of biomaterial property-DC phenotype relationships is expected to inform rational design of immuno-modulatory biomaterials. In this study, DC response to a set of 12 polymethacrylates (pMAs) was assessed in terms of surface marker expression and cytokine profile. Principal component analysis (PCA) determined …
Photoinduced Polymer Chain Scission Of Alkoxyphenacyl Based Polycarbonates, Shuangyi Sun, Elaheh Chamsaz, Abraham Joy
Photoinduced Polymer Chain Scission Of Alkoxyphenacyl Based Polycarbonates, Shuangyi Sun, Elaheh Chamsaz, Abraham Joy
Abraham Joy
We report the design and development of a new class of alkoxyphenacyl based photodegradable polycarbonates. These polymers incorporate the photoactive moiety in the backbone and, when irradiated at 300 nm, undergo controlled chain scission. Micropatterned thin films of these polymers were fabricated by photolithographic techniques. The use of these photodegradable polymers for controlled release applications was demonstrated by the release of Nile Red from polymeric nanoparticles. In addition, these polymers are mechanically robust, thermally stable, and hydrolytically degradable.
Halogenated Squaraine Dyes As Potential Photochemotherapeutic Agents. Synthesis And Study Of Photophysical Properties And Quantum Efficiencies Of Singlet Oxygen Generation*, Abraham Joy
Abraham Joy
The photophysical properties of two pairs of squaraine molecules where two oxygen atoms in a squaraine bridge are replaced with sulfur atoms are investigated. This substitution leads to an inversion of the lowest singlet π−π* electronic transition by an n−π* transition, effectively reducing the energy difference between singlet and triplet states and significantly increasing the intersystem crossing efficiency without the use of “heavy atoms”. Experimental results, in agreement with quantum chemical calculations, show near-unity values for triplet quantum yield and singlet oxygen generation quantum yield for sulfur-containing squaraines, which are potentially useful for two-photon photodynamic therapy.Keywords (keywords): squaraine dyes; intersystem …