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An Investigation Of The Role Of Basigin-Variant-1 In The Immune Response Within The Retina, Abigail D. Tompa
An Investigation Of The Role Of Basigin-Variant-1 In The Immune Response Within The Retina, Abigail D. Tompa
UNF Graduate Theses and Dissertations
The neural retina is considered an immune privileged area, in that the eye attempts to suppress the inflammatory response to preserve vision. If there is damage to the blood-retina barrier, such as in diabetes or macular degeneration, it is possible for monocytes to travel out of the blood vessels and into the retina. While studying retinoblastoma, a research group determined that the protein, Basigin, through its extracellular domain, elicits an immune response by enhancing transcription of the pro-inflammatory cytokine interleukin-6 (IL-6). Basigin is cell adhesion molecule that belongs to the immunoglobulin superfamily. The Basigin gene has two main transcripts, that …