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Capn5 Expression In The Healthy And Regenerating Zebrafish Retina, Cagney E. Coomer, Ann C. Morris
Capn5 Expression In The Healthy And Regenerating Zebrafish Retina, Cagney E. Coomer, Ann C. Morris
Biology Faculty Publications
PURPOSE. Autosomal dominant neovascular inflammatory vitreoretinopathy (ADNIV) is a devastating inherited autoimmune disease of the eye that displays features commonly seen in other eye diseases, such as retinitis pigmentosa and diabetic retinopathy. ADNIV is caused by a gain-of-function mutation in Calpain-5 (CAPN5), a calcium-dependent cysteine protease. Very little is known about the normal function of CAPN5 in the adult retina, and there are conflicting results regarding its role during mammalian embryonic development. The zebrafish (Danio rerio) is an excellent animal model for studying vertebrate development and tissue regeneration, and represents a novel model to explore the …