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Altered T Cell-Mediated Immunity And Infectious Factors In Autism, Yong Hu
Altered T Cell-Mediated Immunity And Infectious Factors In Autism, Yong Hu
All Graduate Theses and Dissertations, Spring 1920 to Summer 2023
Three major questions were addressed in this dissertation: 1) Do immune abnormalities associated with autism primarily alter CD4+ T cell-mediated or humoral immune responses? 2) Are specific T cell clones expanded in autism? 3) Which, if any, infectious agents play a role in autism?
CD4+ T cell-mediated (Th1) or humoral (Th2) immune responses can be distinguished on the basis of the cytokines expressed. CD4+ T-cells secrete interleukin type 2 (IL-2) and interferon-γ, whereas a Th2 response is associated with secretion of interleukin type 4(IL-4). mRNA extracted from peripheral blood mononuclear nuclear cells (PBMC) showed significantly increased levels of IL-2 and …