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Hyperosmotic Stress Enzyme Signaling Modulates Oct4, Nanog, And Rex1 Expression And Induces Prioritized Differentiation Of Murine Embryonic Stem Cells, Jill A. Slater
Wayne State University Dissertations
HYPEROSMOTIC STRESS ENZYME SIGNALING MODULATES OCT4, NANOG,
AND REX1 EXPRESSION AND INDUCES PRIORITIZED DIFFERENTIATION OF
MURINE EMBRYONIC STEM CELLS
by
JILL SLATER
MAY 2013
Advisor: Daniel Rappolee, Ph.D.
Major: Physiology
Degree: Doctor of Philosophy
Transcription factor expression and therefore lineage identity in the periimplantation
embryo and its stem cells may be influenced by extracellular stresses,
potentially affecting pregnancy outcome. Cellular stress forces cells to suppress some
normal activities (such as protein synthesis and cell proliferation) in order to repair
stress-damaged macromolecules and restore homeostasis. Therefore, any new
activities that embryonic cells initiate while concurrently funding the demands of the
stress …