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Manganese Chloride Effects Chondrogenesis Of Atdc5 Cells, Isabella Somera

Seton Hall University Dissertations and Theses (ETDs)

Manganese is an essential trace element found in humans, which aids in several processes including brain and nerve function, glucose metabolism, calcium absorption, and bone formation and homeostasis. Specifically, bone homeostasis utilizes osteoblasts and osteoclasts, cells which function to build and reabsorb bone respectively, as well as chondrocytes, cells which aid in endochondral ossification. Chondrocytes deposit extracellular matrix components, such as aggrecan, collagen, and proteoglycans, that provide the necessary scaffold for osteoblasts to synthesize and mineralize bone. Activation of the rapamycin (mTOR) pathway influences the regulation of several cellular processes, such as skeletal development and bone homeostasis. In this study, …