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Segmentation Of Dna Lesions In Irradiated Mouse Brain Sections, Nicholas Cirone
Segmentation Of Dna Lesions In Irradiated Mouse Brain Sections, Nicholas Cirone
Honors Capstones
The impacts of microscopy image analysis have resulted in better visualization of foci (spots) in cell nuclei. However, manual analysis of microscopy images is challenging regarding subjectivity in structure counting and identification. Recent computer algorithms have enabled cellular analysis through automatic segmentation that uses computational edges in digital images. In this project, the automatic segmentation workflow in the Zeiss Zen Blue 3.3 software was adapted to more closely reflect visualized foci in a cell. The foci represent DNA double strand breaks. The Zeiss LSM 900 microscope was used to collect maximal intensity projection images of γH2AX foci and super-resolution z-stacks …
Nutrient Scarcity And Cellular Cooperation In A Clonal Hydroid, Weam S. El Rahmany
Nutrient Scarcity And Cellular Cooperation In A Clonal Hydroid, Weam S. El Rahmany
Graduate Research Theses & Dissertations
Biological complexity forms when lower-level units (e.g., genes, cells, organisms) cooperatively band together. This complexity may be exemplified by multicellularity, the cooperation between the cells of the same species, or symbiosis, cooperation between the cells of different species. This cooperation is under continual threat, as defection, the opposite of cooperation, is favored by default by lower-level units (i.e., cells). Animal cancers may be the most well-known phenomena that exemplify the concept of cellular defection. Cancer cells have been shown to feature morphological and metabolic traits, developed through differential gene expression or mutations, that favor their growth at the cost of …