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Modeling 3d Retinogenesis In Mouse Embryonic Stem Cells Following Crispr-Mediated Crx Knockdown, Pooja Prasad
Modeling 3d Retinogenesis In Mouse Embryonic Stem Cells Following Crispr-Mediated Crx Knockdown, Pooja Prasad
Dissertations, Masters Theses, Capstones, and Culminating Projects
An emerging technology known as three-dimensional (3D) tissue engineering has allowed scientists to mimic tissues found in vivo. Previous studies indicate that it is possible to differentiate dissociated mouse embryonic stem cells (mESCs) into 3D retinal tissues in vitro (Bertacchi, 2015; Eiraku, 2012). The newly differentiated retinal tissues are said to encompass all of the major components found in retinal tissues. The generation of in vitro 3D tissues holds great potential in terms of patient-specific disease modeling. Although various diseases have been well-studied in animal models, there are limitations with regards to patient-specificity. The generation of animal models to study …
The Developmental And Genetic Basis Of Differences In Cave And Surface-Dwelling Forms Of The Crustacean, Asellus Aquaticus, Hafasa Mojaddidi
The Developmental And Genetic Basis Of Differences In Cave And Surface-Dwelling Forms Of The Crustacean, Asellus Aquaticus, Hafasa Mojaddidi
Dissertations, Masters Theses, Capstones, and Culminating Projects
Currently, there are many gaps in our understanding of the genetic mechanisms responsible for human diseases. One novel method to bridge these gaps is to investigate the naturally occurring variation of wild populations, which is arguably more similar to the genetic complexity present in human disease than artificially induced mutations in model species. Species adapted to subterranean environments often share phenotypic characteristics such as the reduction or complete absence of eyes, reduced pigmentation, and enhanced sensory systems. In order to understand the evolution of these morphological changes, we selected an invertebrate model system the freshwater isopod crustacean Asellus aquaticus, …