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Articles 1 - 29 of 29
Full-Text Articles in Entire DC Network
Qualitative Assessment Of Human Embryonic- And Induced Pluripotent Stem Cell Derived Neural Stem Cells Under Cgmp Methods, Michelle Hernandez
Qualitative Assessment Of Human Embryonic- And Induced Pluripotent Stem Cell Derived Neural Stem Cells Under Cgmp Methods, Michelle Hernandez
Electronic Theses, Projects, and Dissertations
Neural stem cell therapies represent a promising tool for the development of regenerative medicine and are being tested in clinical trials for several neurological disorders. However, the clinical applicability of stem cell therapies is dependent on the implementation of current good manufacturing practices (cGMPs) to ensure the quality, safety, and consistency that stem cell products need to meet FDA regulatory requirements. As such, there is a need for a shift to xeno-free methodologies so experimental conditions are cGMP compliant. The purpose of this study is to test a GMP compatible production method to generate multipotent neural stem cells (NSCs) from …
Early Development Of C3ar1-Targeting Chimeric Antigen Receptor T Cells For The Treatment Of Glioblastoma Multiforme, Cameron Fraser
Early Development Of C3ar1-Targeting Chimeric Antigen Receptor T Cells For The Treatment Of Glioblastoma Multiforme, Cameron Fraser
Electronic Theses, Projects, and Dissertations
Glioblastoma multiforme is the most aggressive type of glioma, demonstrating extremely low long-term survival despite modern therapies. Chimeric antigen receptor T cells have shown extreme levels of success in the treatment of B cell lymphomas through persistent anti-tumor activity. Prior research has demonstrated the therapeutic potential in targeting the C3a-C3aR1 pathway as it acts in an autocrine loop, maintaining the proliferation and survival of cancer stem cells within the tumor. Here, we reorient the treatment to target C3aR1 for the treatment of glioblastoma multiforme. In order to achieve this, Jurkat immortalized T cells will express various chimeric antigen receptor designs …
Neonatal Islet-1+ Cardiovascular Progenitor Cell-Derived Exosomes And Their Functional Ability To Regulate Proliferation, Lourdes Ceja
Neonatal Islet-1+ Cardiovascular Progenitor Cell-Derived Exosomes And Their Functional Ability To Regulate Proliferation, Lourdes Ceja
Electronic Theses, Projects, and Dissertations
Heart failure affects many people around the world and can lead to disease progression and death. Consequently, new stem and exosome-based therapies are needed to address this major health issue and to provide therapeutic options that will improve outcomes for the increasing number of patients with heart disease. Stem cell-derived exosomes have captivated researchers’ attention over the past couple of years based on their functional role in cellular signaling which highlights the vital component of the secretome of stem and progenitor cells. Since neonates have significantly enhanced regenerative ability, we hypothesized that exosomes isolated from Islet-1+ expressing neonatal human cardiovascular …
The Role Of The Erbb Signaling Pathway In Cardiovascular Progenitor Cell-Based Repair, Christopher Ramos
The Role Of The Erbb Signaling Pathway In Cardiovascular Progenitor Cell-Based Repair, Christopher Ramos
Electronic Theses, Projects, and Dissertations
Adult mammalian hearts lack self-renewal and proliferative capabilities necessary for cardiovascular regeneration. Current treatments using cardiac progenitor cells (CPCs) for cell-based repair do not restore cardiac function in patients who experience a myocardial infarction (MI). Our laboratory has been studying Islet-1+ neonatal CPCs as a promising candidate for cell-based repair due to their ability to significantly improve cardiac function after MI in sheep. The current study addresses the hypothesis that the ERBB pathway is linked to the Hippo-pathway to activate YAP1 by the involvement of an autocrine loop that upregulates neuregulin (NRG). In our sheep model of MI and cardiovascular …
Epithelial-Mesenchymal Status Predics Tumor Agressivenss, Chemoresistance And Invasiveness In High Grade Serous Ovarian Cancer, Linda Sanderman
Epithelial-Mesenchymal Status Predics Tumor Agressivenss, Chemoresistance And Invasiveness In High Grade Serous Ovarian Cancer, Linda Sanderman
Electronic Theses, Projects, and Dissertations
High Grade Serous Ovarian Cancer (HGSOC) is one of the deadliest gynecological diseases in the United States ranking fifth in cancer deaths among women. Approximately 22 thousand new cases are expected to occur in the year 2020, and unfortunately, it is estimated that 14 thousand women will succumb to the disease; the incidence to death ratio, 64%, remains high despite current research. Current treatment includes debulking surgery followed by combinatorial chemotherapeutics with platinum-based and taxol-based compounds. But despite aggressive surgery and standard-of-care chemotherapeutics, 80% of patients will experience a recurrence and only 15-30% of those with recurring disease will respond …
Prioritizing Chemical Constituents In Tobacco Products And Smoke To Predict Developmental Osteotoxicity In Human Embryonic Stem Cells, Joseph Madrid
Prioritizing Chemical Constituents In Tobacco Products And Smoke To Predict Developmental Osteotoxicity In Human Embryonic Stem Cells, Joseph Madrid
Electronic Theses, Projects, and Dissertations
Though it is well known that tobacco related products can cause prenatal maldevelopment, very little is known on how tobacco products affect bone tissue as it develops in the embryo. Identifying which chemicals can induce the greatest harm to the prenatal skeletal system is an improbable task as there are over 7,000 chemicals in tobacco smoke alone. We hypothesized that the Toxicological Priority Index (ToxPI) program can be used to rank osteogenic cytotoxicity potential to aid in the assessment of what chemicals out of the thousands can cause osteogenic differentiation inhibition. ToxPI aggregates information from various assays and incorporates them …
Platelet Derived Growth Factor Receptor B (Pdgfrb) Expressing Cells During Zebrafish Coronary Vessel Development, Juancarlos Fierros
Platelet Derived Growth Factor Receptor B (Pdgfrb) Expressing Cells During Zebrafish Coronary Vessel Development, Juancarlos Fierros
Electronic Theses, Projects, and Dissertations
Coronary heart disease is a prevalent issue in developed countries throughout the world. It can have crippling effects on the quality of life and even lead to mortality, in the case of myocardial infarction. Part of the problem is the lack of a robust regenerative response in mammals after injury. Zebrafish have an amazing ability to regenerate after injury, and studies have demonstrated that the regenerative response recapitulates embryonic development. Our lab previously reported the first analysis of coronary vessel development in zebrafish and demonstrated that coronary endothelial cells undergo angiogenesis to form a vascular network. The roles of perivascular …
Influencing Pathways That Cause Metastasis And Stemness In Epithelial Ovarian Cancer, Alyse Lynn Huisken-Hill
Influencing Pathways That Cause Metastasis And Stemness In Epithelial Ovarian Cancer, Alyse Lynn Huisken-Hill
Electronic Theses, Projects, and Dissertations
Ovarian cancer is the fifth leading cause of cancer death in women between the ages of 35 and 74. With 22 thousand new cases and 15 thousand deaths annually ovarian cancer is among the most deadly cancers with a death to incidence ratio of 68%. With 70% of cases High Grade Serous Ovarian Carcinoma (HGSOC) is the most common type of ovarian cancer and causes 90% of ovarian cancer deaths. 80% of patients have reoccurrence within five years and only 15-30% of patients with recurrent metastatic ovarian cancer respond to current therapies, chemotherapy and surgery. One reason for the high …
Priming Cardiovascular Stem Cells For Transplantation Using Short-Term Hypoxia, Ivan Hernandez
Priming Cardiovascular Stem Cells For Transplantation Using Short-Term Hypoxia, Ivan Hernandez
Electronic Theses, Projects, and Dissertations
Conventional medical treatments fail to address the underlying problems associated with the damage inflicted by a coronary event. Thus, the long-term prognosis of patients admitted for heart failure is disheartening, with reported survival rates of 25 percent. Recent advances in stem cell research highlight the potential benefits of autologous stem cell transplantation for stimulating repair in heart tissue. However, a majority of those suffering from cardiovascular diseases are older adults whose autologous cells no longer possess optimum functional capacity. Additional work is needed to identify the optimal cell types or conditions that will promote cardiovascular regeneration across all age groups. …
Elucidating The Effects Of Tobacco Products On Skeletal Development, Nicole Renee Sparks
Elucidating The Effects Of Tobacco Products On Skeletal Development, Nicole Renee Sparks
Theses Digitization Project
The overall goal of this thesis project is to characterize the molecular mechanisms of tobacco product induced skeletal teratogenicity.
Elucidating The Role Of Bone Morphogenetic Proteins And B-Lymphocyte Maturation Protein 1 During Primordial Germ Cell Specification, Laughing Bear Torrez Dulgeroff
Elucidating The Role Of Bone Morphogenetic Proteins And B-Lymphocyte Maturation Protein 1 During Primordial Germ Cell Specification, Laughing Bear Torrez Dulgeroff
Theses Digitization Project
This study will present an optimized protocol to induce and isolate primordial germ cells (PGC) from hESC and hiPSC. Human embrionic stem cells (hESC and induced pluripotent stem cells (iPSC) provide a model for studying paradigms of early development.
Limb Bone Geometry And Skeletal Physiology In Mice Bred For High Levels Of Activity, Brittney Racheal Coats
Limb Bone Geometry And Skeletal Physiology In Mice Bred For High Levels Of Activity, Brittney Racheal Coats
Theses Digitization Project
The studies presented here evaluate the effects of exercise and genetics on biomechanically important traits and the skeletal system's role in maintaining proper metabolic health. The goal of the project presented here is to further our understanding of the leptin-bone-insulin pathway and relevant changes that may occur in this pathway as a result of exercise. Cross-sectional analyses of HR mice and control mice allowed or denied wheel access for 10 weeks, revealed significant differences in biomechanical properties.
The Effects Of R-Flurbiprofen In Reducing Tumors In A Multiple Intestinal Neoplasia Mouse Model, David Douglas Quiggle
The Effects Of R-Flurbiprofen In Reducing Tumors In A Multiple Intestinal Neoplasia Mouse Model, David Douglas Quiggle
Theses Digitization Project
The design of the proposed study was to administer R-FB to 72-day old Min/+ mice for up to 42 days. In order to capture the process of tumor reduction, animals were necropsied at various time points. At each time point animals were evaluated for tumor loads and presence of apoptotic cells along the small intestine. Studies have shown that when R-flurbiprofen (R-FB) is administered in the Min/+ mouse model it can cause the prevention and regression on intestinal tumors.
Concentration Of Specific Biogenic Amines In Ventricular Csf Of Type A And B Parkinson's Disease Patients On Sinemet, Justin Robert Ahlman
Concentration Of Specific Biogenic Amines In Ventricular Csf Of Type A And B Parkinson's Disease Patients On Sinemet, Justin Robert Ahlman
Theses Digitization Project
No abstract provided.
Relative Involvement Of Different Cnidocyte Supporting Cell Complexes And Extracellular Calcium In Prey Capture Of Sea Anemone, Haliplanella Luciae, Virginia Nenna Mc Auley
Relative Involvement Of Different Cnidocyte Supporting Cell Complexes And Extracellular Calcium In Prey Capture Of Sea Anemone, Haliplanella Luciae, Virginia Nenna Mc Auley
Theses Digitization Project
No abstract provided.
Characterization Of Early Activation Of Multi-Isotypic Antibody-Producing B Lymphocytes In The Small Intestine, Stephen Douglas Wagner
Characterization Of Early Activation Of Multi-Isotypic Antibody-Producing B Lymphocytes In The Small Intestine, Stephen Douglas Wagner
Theses Digitization Project
No abstract provided.
Morphological Constraints On Life History Evolution In Poecilia Reticulata (Cyprinodontiformes: Poeciliinae), Edmund Richard Miranda
Morphological Constraints On Life History Evolution In Poecilia Reticulata (Cyprinodontiformes: Poeciliinae), Edmund Richard Miranda
Theses Digitization Project
No abstract provided.
The Effects Of 60-Hz Electromagnetic Fields And Teratogens On Drosophila Melanogaster Embryonic Cultures: Analysis Of Heat Shock Proteins 23 And 70, Edmund James Koundakjian
The Effects Of 60-Hz Electromagnetic Fields And Teratogens On Drosophila Melanogaster Embryonic Cultures: Analysis Of Heat Shock Proteins 23 And 70, Edmund James Koundakjian
Theses Digitization Project
No abstract provided.
The Effect Of Triiodothyronine On Glut4 Protein Expression In Skeletal Muscle And Adipose Tissue Of Obese-Diabetic (Db/Db) Mice, Paula Joanne Estrada
The Effect Of Triiodothyronine On Glut4 Protein Expression In Skeletal Muscle And Adipose Tissue Of Obese-Diabetic (Db/Db) Mice, Paula Joanne Estrada
Theses Digitization Project
No abstract provided.
Assessment Of Anti-Neoplastic Activity In Cancerous And Non-Cancerous Cells Using Nuclear Growth Indicators, James Michael Williams
Assessment Of Anti-Neoplastic Activity In Cancerous And Non-Cancerous Cells Using Nuclear Growth Indicators, James Michael Williams
Theses Digitization Project
No abstract provided.
Preparation Of A Site-Specific Lymphotoxin- Mutant To Be Used In Protein Characterization And Receptor Binding Studies, Derek Andrew Knight
Preparation Of A Site-Specific Lymphotoxin- Mutant To Be Used In Protein Characterization And Receptor Binding Studies, Derek Andrew Knight
Theses Digitization Project
No abstract provided.
Induction Of Heat Shock Protein 70 In Chinese Hamster Ovary Cells During Chlamydia Trachomatis Infection, Tsehay Eshete Mekonnen
Induction Of Heat Shock Protein 70 In Chinese Hamster Ovary Cells During Chlamydia Trachomatis Infection, Tsehay Eshete Mekonnen
Theses Digitization Project
No abstract provided.
Maturation Modulates Both Synthesis And Degradation Of Cgmp In Ovine Vascular Smooth Muscle, Charles Ray White
Maturation Modulates Both Synthesis And Degradation Of Cgmp In Ovine Vascular Smooth Muscle, Charles Ray White
Theses Digitization Project
No abstract provided.
Cervical Cancer: A Retrospective Study Of The Dna Ploidy Status Using Flow Cytometry And Its Prognostic Applications, Omar Roberto Fagoaga
Cervical Cancer: A Retrospective Study Of The Dna Ploidy Status Using Flow Cytometry And Its Prognostic Applications, Omar Roberto Fagoaga
Theses Digitization Project
No abstract provided.
The Effects Of Teratogens On Serotonin Expression In Drosophila Embryonic Cell Cultures, Keri Joel Hopkins
The Effects Of Teratogens On Serotonin Expression In Drosophila Embryonic Cell Cultures, Keri Joel Hopkins
Theses Digitization Project
No abstract provided.
Characterization Of Early B Lymphocyte Activation During Trichinella Spiralis Infection In Rats, Elizabeth Margaret Richards
Characterization Of Early B Lymphocyte Activation During Trichinella Spiralis Infection In Rats, Elizabeth Margaret Richards
Theses Digitization Project
No abstract provided.
Cloning And Immunogenicity Of A Chlamydia Trachomatis 36 Kilodalton Recombinant Gene Product In Escherichia Coli, Hector Rivera
Cloning And Immunogenicity Of A Chlamydia Trachomatis 36 Kilodalton Recombinant Gene Product In Escherichia Coli, Hector Rivera
Theses Digitization Project
No abstract provided.
Characterization Of Pulmonary Surfactant Apoproteins In The Diabetic Mouse, Kenneth Dean Mccarty
Characterization Of Pulmonary Surfactant Apoproteins In The Diabetic Mouse, Kenneth Dean Mccarty
Theses Digitization Project
No abstract provided.
Forms Of Phosphorus In Nutrition Of Halobacterium Halobium And Halobacterium Salinarium, Pramodbala Parekh
Forms Of Phosphorus In Nutrition Of Halobacterium Halobium And Halobacterium Salinarium, Pramodbala Parekh
Theses Digitization Project
No abstract provided.