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Oncostatin M Promotes Breast Cancer Metastasis: Increased Expression Of Pro-Angiogenic Factors, Inflammatory Cytokine Expression, And Circulating Tumor Cell Numbers, Ken Tawara
Boise State University Theses and Dissertations
Breast cancer is the most diagnosed cancer type in women and its resultant mortality is second only to lung cancer worldwide. While breast cancer is known to have many risk factors, inflammation remains an unquantifiable risk, and it can arise from obesity, depression, poor health, autoimmune diseases, and other conditions that cause systemic chronic inflammation. Chronic inflammation is gaining recognition for its role in cancer development, the potentiation of a metastatic phenotype in cancer cells, and decreased survival in breast cancer patients. In particular, inflammatory cytokines in the interleukin-6 (IL-6) family have been shown to promote an epithelial-mesenchymal transition (EMT), …
The Role Of Col11a1 Expression During Cartilage Development, Jonathon Charles Reeck
The Role Of Col11a1 Expression During Cartilage Development, Jonathon Charles Reeck
Boise State University Theses and Dissertations
It is currently a major scientific and medical goal to identify and characterize genetic defects and their impact in health and disease. For example, mutations in genes that encode collagen alpha chains can cause skeletal dysplasia and lead to premature degenerative joint disease. Collagen is the main structural protein in the ECM of connective tissues such as the cartilage, joints, ligaments and tendons. Therefore, the goal of this research is to define the impact of the alpha one chain of collagen type XI chain, encoded by the COL11A1 gene in humans, on chondrocyte behavior during development of the cartilage. We …