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Do Pcsk9 Monoclonal Antibodies Plus Soc Prevent Major Adverse Cardiovascular Events In Adults With Hypercholesterolemia Compared To Placebo Plus Soc?, Amy Doyle
PCOM Physician Assistant Studies Student Scholarship
Objective: The objective of this selective EBM review is to determine whether or not PCSK9 monoclonal antibodies plus SOC prevent major adverse cardiovascular events in adults with hypercholesterolemia compared to placebo plus SOC.
Study Design: This review is using one double-blinded randomized controlled trial (RCT) and two open-label RCTs investigating alirocumab and evolocumab, published in 2014 and 2015.
Data sources: Articles were found on PubMed, and were published in peer-reviewed journals in English.
Outcome Measured: The outcome measured was major adverse cardiac events (MACE), which included death, MI, hospitalization for unstable angina, revascularization, or cerebrovascular event. …
Is Pharmacologic Therapy For Blood Pressure Control Effective At Reducing Symptoms And Improving Quality Of Life In Patients With Postural Orthostatic Tachycardia Syndrome (Pots)?, Christopher S. Sokalski
Is Pharmacologic Therapy For Blood Pressure Control Effective At Reducing Symptoms And Improving Quality Of Life In Patients With Postural Orthostatic Tachycardia Syndrome (Pots)?, Christopher S. Sokalski
PCOM Physician Assistant Studies Student Scholarship
Objective The objective of this selective EBM review is to determine whether or not pharmacologic therapy for blood pressure control effective at reducing symptoms and improving quality of life in patients with postural orthostatic tachycardia syndrome (POTS).
Study Design Systematic review of two single blind crossover randomized control trials published in 2009 and 2012 and one retrospective case control study published in 2009.
Data Sources Three studies were obtained using PubMed. Outcomes Measured Self reported symptoms of POTS and the Vanderbilt POTS symptom scoring system as well as quality of life in patients.
Results Raj et al. (2009), Coffin et …