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Polyvinyl Alcohol (Pva)-Based Nanoniosome For Enhanced In Vitro Delivery And Anticancer Activity Of Thymol, Mohammadreza Abdihaji, Masoumeh Mirzaei Chegeni, Alireza Hadizadeh, Negar Farrokhzad, Zahra Kheradmand, Parastoo Fakhrfatemi, Fardad Faress, Kasra Moeinabadi-Bidgoli, Hassan Noorbazargan, Ebrahim Mostafavi
Polyvinyl Alcohol (Pva)-Based Nanoniosome For Enhanced In Vitro Delivery And Anticancer Activity Of Thymol, Mohammadreza Abdihaji, Masoumeh Mirzaei Chegeni, Alireza Hadizadeh, Negar Farrokhzad, Zahra Kheradmand, Parastoo Fakhrfatemi, Fardad Faress, Kasra Moeinabadi-Bidgoli, Hassan Noorbazargan, Ebrahim Mostafavi
Information Systems Faculty Publications and Presentations
Introduction: There is an unmet need to develop potent therapeutics against cancer with minimal side effects and systemic toxicity. Thymol (TH) is an herbal medicine with anti-cancer properties that has been investigated scientifically. This study shows that TH induces apoptosis in cancerous cell lines such as MCF-7, AGS, and HepG2. Furthermore, this study reveals that TH can be encapsulated in a Polyvinyl alcohol (PVA)-coated niosome (Nio-TH/PVA) to enhance its stability and enable its controlled release as a model drug in the cancerous region.
Materials and Methods: TH-loaded niosome (Nio-TH) was fabricated and optimized using Box–Behnken method and the …