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A Data Gathering Toolkit For Biological Information Integration, Munira Lokhandwala
A Data Gathering Toolkit For Biological Information Integration, Munira Lokhandwala
Theses
SYSTERS is a biological information integration system containing protein sequences from many protein databases such as Swiss-Prot and TrEMBL and also protein sequences from complete genomes available at Ensembl, The Arabidopsis Information Resource, SGD and GeneDB. For some protein sequences their encoding nucleotide sequences can be found in their corresponding websites. However, for some protein sequences their encoding nucleotide sequences are missing.
The goal of this thesis is to. collect all nucleotide sequences for the protein sequences in SYSTERS and store them in a common database. There are two cases. The first case is that if the nucleotide sequences can …
Network Activity Arising From Optimal Diameters Of Neuronal Processes, Juliane Gansert
Network Activity Arising From Optimal Diameters Of Neuronal Processes, Juliane Gansert
Theses
Electrical coupling provides an important pathway for signal transmission between neurons. In several regions of the mammalian brain electrical synapses have been detected, and their role in the synchronization of neural networks and the generation of oscillations has been studied theoretically. Recently, it has been found that the amplitude of the postsynaptic potential is maximized for a specific diameter of the postsynaptic fiber.
In this thesis, the impact of the fiber's diameter on the success or failure of the action potential initiation and propagation is studied theoretically. Systems of two coupled neurons, as well as small networks, are investigated. The …
Comparative Analysis Of Parametric, Nonparametric And Permutation Methods For Differential Expression, Rahul Patil
Comparative Analysis Of Parametric, Nonparametric And Permutation Methods For Differential Expression, Rahul Patil
Theses
DNA microarrays permit us to study the expression of thousands of genes simultaneously. They are now used in many different contexts to compare mRNA levels between two or more samples of cells. Microarray experiments typically give us expression measurements on a large number of genes. Increasing popularity of microarray technology has resulted in a number of tests being proposed to detect differentials expression.
The purpose of study is to compare the parametric, non parametric and permutation tests when applied to microarray data for differential expression analysis. t test (parametric), Mann Whitney test (nonparametric) and Significance of analysis (permutation ) test …